DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS4 and ints4

DIOPT Version :9

Sequence 1:	NP_572488.1	Gene:	IntS4 / 31793	FlyBaseID:	FBgn0026679	Length:	1022	Species:	Drosophila melanogaster
Sequence 2:	XP_002936595.2	Gene:	ints4 / 100498633	XenbaseID:	XB-GENE-5841108	Length:	969	Species:	Xenopus tropicalis

Alignment Length:	1086	Identity:	365/1086 - (33%)
Similarity:	555/1086 - (51%)	Gaps:	183/1086 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALAIKKRV-GTYVETVD----GSPPVKKLRLQTLAADAKGGKSGKVGNVERKLTALNQLDAYVG 60
            ||..:|||| ..:...|.    ..|..|||||      .|..||           |...:|....
Frog     1 MAAHLKKRVYEEFTRVVQQQPLEEPSAKKLRL------TKPSKS-----------AALHIDLCKA 48

  Fly    61 NLPAGALVLPTGTPVASTGAPSTGVIGNPPAAATGAPPMTAANSRELLELLVKITDEISYEDVEM 125
            ..||.||                                     :.||:...|        .||.
Frog    49 TSPADAL-------------------------------------QYLLQFARK--------PVEA 68

  Fly   126 GELKEVASKIFQLYQLQERDSDTSIRVK---LLELLSGLGCECATEQALTMIIDYFIFLLRKEVS 187
            ..::.|...:.:.|.   :::|||:|:|   ||.|||.....|...     |:|..|..|:.|.|
Frog    69 ESVEGVVRILLEHYY---KENDTSVRLKIASLLGLLSKTAGFCPDS-----IVDDVINTLQNEKS 125

  Fly   188 QKVLAQGMMCLFRIGERRKHMLPISYKTQVAHLAKEQLRSGSAHTQKNAML-VIG-----RFATK 246
            .:||||.:..|..||  .|.:..:|::.|:..:|.:.| |.::|..:|..| ::|     ..:|.
Frog   126 HQVLAQLLDTLLEIG--IKLLDSVSHRMQLVDVACKHL-SDTSHGVRNKCLQLLGCLGSVEASTA 187

  Fly   247 MEGERHY---VWKLA--FYIDSQDSSVRAQALHALLTLGERGSQLPAVLYKRAVEAMKDDYECVR 306
            .|.|...   |.|:.  ::|| ||..||..|:.|:|.|.|||.:|...:|.:|.:.:.||||.||
Frog   188 KEVENAVTKDVQKIIGDYFID-QDPRVRTAAIKAMLQLHERGLKLQQAMYNQACKLLTDDYEQVR 251

  Fly   307 KEALQLVFMLGNRHPDYILPSDRQQEELRMIDAAFSKVCEALCDLSLQIRVLAAELLGGMTAVSR 371
            ..|.:|:::|....|:.|:|.....||:|::|.||.|.|..:.|.|..:||.|.:|||.|..||.
Frog   252 SAAAELIWVLSQLFPESIVPIPSSNEEIRLVDDAFGKACHMVSDGSWVVRVKACKLLGSMLQVSP 316

  Fly   372 EFLHQTLDKKLMSNLRRKRTAHERGARLVASGEWSSGKRWADDAPQEHLDAQSISIIASGACGAL 436
            .||.|||||||||:||||||||||...|.:|||:|||::|.||||:|.||..::::|.||||||.
Frog   317 HFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEELDTGAVNLIDSGACGAF 381

  Fly   437 IHGLEDEFLEVRTAAVASMCKLALSRPDFAVTSLDFLVDMFNDEIEDVRLKAIYSLTAIAKHIVL 501
            :||||||..|||.|||.|:|.||.|...||...|||||||||||||:|||::|:::..|:.:|.|
Frog   382 VHGLEDEMYEVRIAAVESLCLLARSSAPFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISDNITL 446

  Fly   502 REDQLEIMLGSLEDYSVDVREGLHLMLGACRVSTQTCLLMVVQKLLDVLAKYPQDRNSTYACMRK 566
            |||||:.:|..|||.|.|:||.||.:|....|||:.|:.:.:.:||..|:|||.||.|.:.|::.
Frog   447 REDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKECIQLALVELLKNLSKYPTDRESIWKCLKF 511

  Fly   567 IGQKHPHLVMAVAVHLLYVHPFFETPERDVEDPAYLCVLILVFNAAEHLVPIISLLPTATHRHYA 631
            :|.:||.||:::...||..||||:|||.|::||||:.||:|:||||:....:.:|....|.||||
Frog   512 LGSRHPTLVLSLVPELLSTHPFFDTPEPDMDDPAYIAVLVLIFNAAKCCPTMPALFSDHTFRHYA 576

  Fly   632 YLRDSMPNLVPQLPIEGASSASATHRIDSAMHQAGSSAEYLQMILSHIEEIFTMTDE-RLELLQT 695
            |||||:.:|||.|.:.....:.....:..|..: ..|.::||:.|..::.:..:..: ..|||:.
Frog   577 YLRDSLSHLVPALNLPSVRWSWVPDVVTEAPPE-DPSQQFLQLSLERVQNLQHLGSQGTQELLEF 640

  Fly   696 AQSNLQRLGSIDAGMYGTSNFLETFLAAQIQI-----EQMQRCASTQRSRVPLKESLAA-----L 750
            ...:|||:|.:.:.:.|.::|..|:|...:.:     |::...|:.    :.||.|:..     :
Frog   641 TIRDLQRIGELQSELAGMADFSATYLRCHLLLTKALNEKLWSLAAP----LFLKNSVTTNAVKQI 701

  Fly   751 IRNCLKLQHTFSGLNYGDILQVKQLRLRACALHLVLVVRDR--SQSALGPCQMLLQTAGDISE-F 812
            :....|::..:|||....:..:..:||:|.||.|::..|..  ::...|.|:..||....... |
Frog   702 LEETYKMEFMYSGLETRQVAIIHHMRLQAKALQLLVTARTTKGAEPLFGMCEEFLQEVDFFQRCF 766

  Fly   813 IKANTKDEEEKPPVVETDMPMKESVSRDAQPDSFTRQLLIKLDGISDPKPGRVFREILPLVQQAP 877
            |               :::|..:        :||..:||..:..:.:.||..:.:.:...::|..
Frog   767 I---------------SELPHMQ--------ESFVDKLLDLVPRLVNSKPLEMVKILQTTLRQCT 808

  Fly   878 --PLALPPANDKIRRCVANILEPCPLQSQDNVIKVTAGLIAAVPFVAEIDNLLESQKADMRIKIK 940
              .|.||   ::|.:..::|:||.  :..||.|:.|:||:.|:...|.::::.|.| :.:::::.
Frog   809 FLRLTLP---EQIHKASSHIIEPA--EESDNPIRFTSGLVVALDVDATLEHVQEPQ-STVKVQVV 867

  Fly   941 YPDQHMHTVVPKQSDFK---PIMTEQGEHKTNVRLRTTILLSHSVWTESSLVEIQLCLA------ 996
            |||..:..:.||.:||:   |     |.|    ||.|.:.|||:.|||...:|::|.||
Frog   868 YPDGQVQIIHPKPADFRNPGP-----GRH----RLITQVYLSHTAWTEPCQIEVRLLLAYSSSRS 923

  Fly   997 ----------------VRPGSE------LELCKPAKVLFAPKPVRR 1020
                            ..|.:|      :...||.||...|||.||
Frog   924 KVLSRASKSAWGESTETGPSTESSTDGTIPFSKPVKVFLMPKPARR 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS4	NP_572488.1	HEAT repeat	290..326	CDD:293787	13/35 (37%)
		HEAT repeat	339..414	CDD:293787	44/74 (59%)
		HEAT repeat	432..459	CDD:293787	18/26 (69%)
		HEAT repeat	468..498	CDD:293787	18/29 (62%)
		HEAT repeat	504..528	CDD:293787	13/23 (57%)
ints4	XP_002936595.2	HEAT repeat	78..103	CDD:293787	10/27 (37%)
		HEAT	85..>309	CDD:224331	81/232 (35%)
		HEAT repeat	113..138	CDD:293787	10/24 (42%)
		HEAT repeat	150..181	CDD:293787	8/31 (26%)
		HEAT repeat	201..223	CDD:293787	8/22 (36%)
		HEAT repeat	235..263	CDD:293787	11/27 (41%)
		HEAT repeat	284..313	CDD:293787	13/28 (46%)
		HEAT repeat	322..349	CDD:293787	20/26 (77%)
		HEAT repeat	362..400	CDD:293787	22/37 (59%)
		HEAT_2	385..473	CDD:379311	52/87 (60%)
		HEAT repeat	413..443	CDD:293787	18/29 (62%)
		HEAT repeat	449..477	CDD:293787	14/27 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	496	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69427
Inparanoid	1	1.050	497	1.000	Inparanoid score	I1347
OMA	1	1.010	-	-		QHG49995
OrthoDB	1	1.010	-	-		D204348at33208
OrthoFinder	1	1.000	-	-		FOG0006609
OrthoInspector	1	1.000	-	-		oto103840
Panther	1	1.100	-	-	LDO	PTHR20938
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4846
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080