DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32221 and CG9316

DIOPT Version :9

Sequence 1:	NP_730456.2	Gene:	CG32221 / 317924	FlyBaseID:	FBgn0052221	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_610051.2	Gene:	CG9316 / 35333	FlyBaseID:	FBgn0032878	Length:	448	Species:	Drosophila melanogaster

Alignment Length:	441	Identity:	102/441 - (23%)
Similarity:	177/441 - (40%)	Gaps:	70/441 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TSILDLDPSSLLFIFKLL-SLEDQLHLARCCRIFRDAF---LRLHRHDFQDVVDKDMSIRT--LE 63
            ||:|||....:..:.:.| .:.|::.||.....||.||   .|:.|:.. |:|    |:.|  |.
  Fly    40 TSLLDLPEDIIRLVLEFLPRITDKVLLACVAPKFRAAFEGWARVQRNAL-DMV----SLETVPLP 99

  Fly    64 DWRTFLWLCGSRIGTLE---SHFDDDHPLQLLPMISRHCYRLKSISIYNATVARAQPYLLRMSSL 125
            ....|..:.|..|..|:   :.:..:.  .|:..:..:|..|:.||..|||
  Fly   100 QLIRFFKVAGPFIRVLQVDCASYQKES--LLVEFVKEYCPNLEEISYSNAT-------------- 148

  Fly   126 EKVHVRNYKSTSKDLIKAIGIHLPRVNSLSLE-----SFERKELQEVRQFSEMLELGLYDDVTAS 185
            ::.|.|:..|..        .||.||....|:     :|:.:..||: :|.|::. |.|......
  Fly   149 DEFHYRSIMSKM--------THLKRVTIECLDAEDVLNFDMQPNQEL-EFFELVN-GCYTGQNLC 203

  Fly   186 EF---ATIVK-------------PMRKLRCLQLRN-AKRFLTTSNLRMLATNCRHLEKLTFNDCD 233
            .|   .|:|.             |::.|..|.|.: ....:..|..:.:|.:|.:|.:|.|:.||
  Fly   204 GFPNLKTLVLRDCLLWNSMEFGIPLKSLHTLDLDDCCFEVMNVSLYQKIAESCTNLVELIFSGCD 268

  Fly   234 ADLLVLPQFVNLKYLQL---YCSEDMKTRLFKALAKSQCSIQLEYLILHRKRWIDEEQAQYISAL 295
            .:..|:.....|:...|   ..|.::.......||:.:.: :|.:|.|..:..|..|.|:.:..|
  Fly   269 TNFEVIANLPKLERCTLKTWMTSNELNIGFLTVLAEKRGN-KLTHLHLSGQFNITNEHARCLGQL 332

  Fly   296 KCLRWLVCKPRDDLCVHHLA---KLSRLECLSIQSAREIGETQLSLLVANNERLRYLNICYCLGI 357
            ..|..|.....|.|...|..   .||:||...:.:...:.:..:..::....:|:.:::..|..|
  Fly   333 SSLTDLRFSNNDILDDDHFKFFNDLSQLERFGLTACGRVMDVGMMRMLRKCPQLKVIDLTDCEQI 397

  Fly   358 TDAFVLDTLASLSKRSAHQTLELFAAATDIRHDIMERLPHEFPLKMLCLNF 408
            |:.||:..:...||.|....: |....|.||..|:....:...|..|.:||
  Fly   398 TEEFVIQAIGFCSKGSGRDVV-LNVKGTMIRRPILTHPDYVNSLNRLKVNF 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32221	NP_730456.2	leucine-rich repeat	197..223	CDD:275381	6/26 (23%)
		leucine-rich repeat	224..244	CDD:275381	6/19 (32%)
		leucine-rich repeat	245..272	CDD:275381	5/29 (17%)
		leucine-rich repeat	273..297	CDD:275381	7/23 (30%)
		leucine-rich repeat	298..319	CDD:275381	6/23 (26%)
		leucine-rich repeat	320..345	CDD:275381	2/24 (8%)
		leucine-rich repeat	346..372	CDD:275381	7/25 (28%)
CG9316	NP_610051.2	leucine-rich repeat	208..221	CDD:275381	2/12 (17%)
		leucine-rich repeat	231..258	CDD:275381	6/26 (23%)
		leucine-rich repeat	259..279	CDD:275381	6/19 (32%)
		leucine-rich repeat	280..309	CDD:275381	5/29 (17%)
		AMN1	310..>411	CDD:187754	22/100 (22%)
		leucine-rich repeat	310..334	CDD:275381	7/23 (30%)
		leucine-rich repeat	335..359	CDD:275381	6/23 (26%)
		leucine-rich repeat	360..385	CDD:275381	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_126608
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810