DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32221 and Fbxl12

DIOPT Version :9

Sequence 1:	NP_730456.2	Gene:	CG32221 / 317924	FlyBaseID:	FBgn0052221	Length:	432	Species:	Drosophila melanogaster
Sequence 2:	NP_001273458.1	Gene:	Fbxl12 / 30843	MGIID:	1354738	Length:	349	Species:	Mus musculus

Alignment Length:	147	Identity:	35/147 - (23%)
Similarity:	64/147 - (43%)	Gaps:	15/147 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LTTSNLRMLATNCRHLEKLTFNDCDADLLVLPQFVN-LKYLQLYCSEDMKTRLFKALAKSQCSIQ 272
            |:.:.:|.|...|.:|::|..:..|..::.:....: |:.|:|:..|.....|.|....:...:
Mouse   112 LSPALMRALGQKCPNLKRLCLHVADLSMVPITSLPSTLRTLELHSCEISMIWLQKEQDPTVLPL- 175

  Fly   273 LEYLILHRKRWIDEEQAQYISALKCLRWL-------VCKPRDDLCVHHLAKLSRLECLSIQSARE 330
            ||.::|.|.....:|..|.::..:.||.|       |.:...|..:..|:.|.|||.|....:.:
Mouse   176 LECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQELSYLQRLEVLGCTLSAD 240

  Fly   331 IGETQLSLLVANNERLR 347
                  |.|:|.:..||
Mouse   241 ------STLLAISRHLR 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32221	NP_730456.2	leucine-rich repeat	197..223	CDD:275381	4/13 (31%)
		leucine-rich repeat	224..244	CDD:275381	3/19 (16%)
		leucine-rich repeat	245..272	CDD:275381	6/26 (23%)
		leucine-rich repeat	273..297	CDD:275381	6/23 (26%)
		leucine-rich repeat	298..319	CDD:275381	7/27 (26%)
		leucine-rich repeat	320..345	CDD:275381	6/24 (25%)
		leucine-rich repeat	346..372	CDD:275381	2/2 (100%)
Fbxl12	NP_001273458.1	F-box-like	<51..73	CDD:289689
		leucine-rich repeat	127..148	CDD:275381	3/20 (15%)
		AMN1	144..>249	CDD:187754	26/111 (23%)
		leucine-rich repeat	149..175	CDD:275381	6/25 (24%)
		leucine-rich repeat	176..200	CDD:275381	6/23 (26%)
		leucine-rich repeat	201..226	CDD:275381	6/24 (25%)
		leucine-rich repeat	227..252	CDD:275381	10/31 (32%)
		leucine-rich repeat	253..276	CDD:275381
		leucine-rich repeat	277..306	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960