DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32221 and FBXL13

DIOPT Version :9

Sequence 1:NP_730456.2 Gene:CG32221 / 317924 FlyBaseID:FBgn0052221 Length:432 Species:Drosophila melanogaster
Sequence 2:NP_001381423.1 Gene:FBXL13 / 222235 HGNCID:21658 Length:825 Species:Homo sapiens


Alignment Length:478 Identity:100/478 - (20%)
Similarity:180/478 - (37%) Gaps:136/478 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 LDPSSLLFIFKLLSLEDQLHLARCCRIFRDAFLRL-------HRHDF---QDVVDKDMSIRTLED 64
            |...::|.||..|||:|.:    .|.....|::.:       :..||   ::|:.....:.||:.
Human   248 LPERAILQIFFYLSLKDVI----ICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQR 308

  Fly    65 WRTFLWLCGSRIGTLESHFDDDHPLQLLPMISR---HCYRLKSISIYNAT---------VARAQP 117
            |         |:..|..:|   ....|.|...|   ||..|:.:::.:..         ::...|
Human   309 W---------RLNVLRLNF---RGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCP 361

  Fly   118 YLLRMSSLEKVHVRNYKSTSKDLIKAIGIHLPRVNSLSL---ESFERKELQEVRQFSEMLELG-- 177
            .:|.:      ::.|...|::.: :.:..|...:.:|||   ..|..|.||       .|.||  
Human   362 GVLCL------NLSNTTITNRTM-RLLPRHFHNLQNLSLAYCRRFTDKGLQ-------YLNLGNG 412

  Fly   178 ----LYDDVTASEFATIVKPMRKLRCLQLRNAKRFLTTSNLRMLATNCRHLEKLTFNDCDADLLV 238
                :|.|::.              |.|       ::....|.:|.:|..:..||.||       
Human   413 CHKLIYLDLSG--------------CTQ-------ISVQGFRYIANSCTGIMHLTIND------- 449

  Fly   239 LPQFVN--LKYLQLYCSE----------DMKTRLFKALAKSQCSIQLEYLILHRKRWIDEEQAQY 291
            :|...:  :|.|...||.          .:....|:||  |.|  :|..:.....:.:.:...::
Human   450 MPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRAL--SAC--KLRKIRFEGNKRVTDASFKF 510

  Fly   292 ISA----LKCLRWLVCKPRDDLCVHHLAKLSRLECLSIQSAREIGETQLSLLVAN--NERLRYLN 350
            |..    |..:....||...|..:..|:.|.:|..|::.:...||:..|...:..  :.|:|.||
Human   511 IDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELN 575

  Fly   351 ICYCLGITDAFVL------DTLASLSKRSA-HQT-------LELFA------AATDIRHDIMERL 395
            :..|:.::||.|:      ..|..||.|:. |.|       :.:|:      :.|||.::.:..|
Human   576 LSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVL 640

  Fly   396 PHEFPLKMLCLNFEC----SDGM 414
            .....||.|.:: ||    .||:
Human   641 SRHKKLKELSVS-ECYRITDDGI 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32221NP_730456.2 leucine-rich repeat 197..223 CDD:275381 5/25 (20%)
leucine-rich repeat 224..244 CDD:275381 5/19 (26%)
leucine-rich repeat 245..272 CDD:275381 9/36 (25%)
leucine-rich repeat 273..297 CDD:275381 3/27 (11%)
leucine-rich repeat 298..319 CDD:275381 5/20 (25%)
leucine-rich repeat 320..345 CDD:275381 5/26 (19%)
leucine-rich repeat 346..372 CDD:275381 10/31 (32%)
FBXL13NP_001381423.1 Sfi1 <112..>224 CDD:400658
F-box-like 245..289 CDD:403981 10/44 (23%)
leucine-rich repeat 285..312 CDD:275381 7/35 (20%)
AMN1 312..497 CDD:187754 45/233 (19%)
leucine-rich repeat 313..336 CDD:275381 7/25 (28%)
leucine-rich repeat 337..362 CDD:275381 1/24 (4%)
leucine-rich repeat 363..387 CDD:275381 4/30 (13%)
leucine-rich repeat 388..406 CDD:275381 7/24 (29%)
leucine-rich repeat 416..441 CDD:275381 7/45 (16%)
leucine-rich repeat 442..491 CDD:275381 14/59 (24%)
leucine-rich repeat 468..490 CDD:275381 4/23 (17%)
leucine-rich repeat 492..515 CDD:275381 2/22 (9%)
leucine-rich repeat 518..542 CDD:275381 6/23 (26%)
AMN1 529..737 CDD:187754 34/135 (25%)
leucine-rich repeat 543..570 CDD:275381 5/26 (19%)
leucine-rich repeat 571..596 CDD:275381 7/24 (29%)
leucine-rich repeat 597..645 CDD:275381 11/47 (23%)
leucine-rich repeat 646..671 CDD:275381 7/18 (39%)
leucine-rich repeat 672..697 CDD:275381
leucine-rich repeat 698..723 CDD:275381
leucine-rich repeat 724..749 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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