DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and OSMR

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001310435.1	Gene:	OSMR / 9180	HGNCID:	8507	Length:	980	Species:	Homo sapiens

Alignment Length:	1178	Identity:	208/1178 - (17%)
Similarity:	356/1178 - (30%)	Gaps:	447/1178 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 QSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVT 391
            ||..:...|:::||.          ::.::||:.:.:.:....:.|:.|     .||     ||.
Human    46 QSLHLQWTVHNLPYH----------QELKMVFQIQISRIETSNVIWVGN-----YST-----TVK 90

  Fly   392 DNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVN 456
            .|.:                    |.:.::             ||.|...:|   ..|.||..|:
Human    91 WNQV--------------------LHWSWE-------------SELPLECAT---HFVRIKSLVD 119

  Fly   457 GS--PKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKE 519
            .:  |:|.. |   |||.:....:||   |...||:.|       .:.::|          :|:|
Human   120 DAKFPEPNF-W---SNWSSWEEVSVQ---DSTGQDILF-------VFPKDK----------LVEE 160

  Fly   520 HTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKT 584
            .|.:|....:..:....|......:.|             |:.:|    |.....|.||:...:.
Human   161 GTNVTICYVSRNIQNNVSCYLEGKQIH-------------GEQLD----PHVTAFNLNSVPFIRN 208

  Fly   585 MELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTI 649
            .  .:..|...::..:.|......|.|..|...||  ..:|:.:..:            .||.|
Human   209 K--GTNIYCEASQGNVSEGMKGIVLFVSKVLEEPK--DFSCETEDFK------------TLHCT- 256

  Fly   650 QFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKI-GASPPSAHSDSCT---TQP 710
                      ||      |.||::......|..:||.    |... |......|.:.|.   ||.
Human   257 ----------WD------PGTDTALGWSKQPSQSYTL----FESFSGEKKLCTHKNWCNWQITQD 301

  Fly   711 D----------------------------VPFKNPDNVVGQGTEPNNLVISW---------TPMP 738
            .                            |...||.:|..:.....|.:::|         |.:.
Human   302 SQETYNFTLIAENYLRKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLC 366

  Fly   739 EIE----------HNAP---NFHYYVS--------------------WKRDIPAAAWENNNIFDW 770
            :||          :|..   |..|::|                    ||       |.     :|
Human   367 QIELHGEGKMMQQYNVSIKVNGEYFLSELEPATEYMARVRCADASHFWK-------WS-----EW 419

  Fly   771 R-QNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGY 834
            . ||...:...|:....:.::|::.                        |.|.|:.
Human   420 SGQNFTTLEAAPSEAPDVWRIVSLE------------------------PGNHTVT--------- 451

  Fly   835 MAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGR 899
            :.|.|:|:....|....|.:.  .||..:....|:|......|:  |:...|..:|...:..|..
Human   452 LFWKPLSKLHANGKILFYNVV--VENLDKPSSSELHSIPAPANS--TKLILDRCSYQICVIANNS 512

  Fly   900 FNGPPSAVI----DFDTPEGVPSPVQGLDAYPLGSSAFMLHWK-KPLYPNGKLTGYKIYYEEVKE 959
            ....|::||    |.:..|.....:.|.:      ..|.|.|| :|    |.:.||.:.:.:..:
Human   513 VGASPASVIVISADPENKEVEEERIAGTE------GGFSLSWKPQP----GDVIGYVVDWCDHTQ 567

  Fly   960 SYVG--ERREYDPHITDPRVTRMKMAGLKPNSKY--RISITATTKMGEGSEHYIEKTTLKDAVNV 1020
            ..:|  :.:...|:.|.   |.:.....:|..:|  ||...:|.::.    ..:||.|
Human   568 DVLGDFQWKNVGPNTTS---TVISTDAFRPGVRYDFRIYGLSTKRIA----CLLEKKT------- 618

  Fly  1021 APATPSFSWEQLPSDNGLA--------KFRINWLP-STEGHP----GTHFFTMHRIKGETQWIRE 1072
                 .:|.|..||||...        .|.::|.. |||..|    |.|.:    :|.:.:....
Human   619 -----GYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVY----LKSKARQCHP 674

  Fly  1073 NEEKN--SDYQE---------------VGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGP 1120
            ..||.  ||..|               |..|.||:.|||.:...              |:..|||
Human   675 RFEKAVLSDGSECCKYKIDNPEEKALIVDNLKPESFYEFFITPF--------------TSAGEGP 725

  Fly  1121 IMVANETVA---NAGWFIGMMLALAFIIILFIIICIIRRN------------------------- 1157
            .....:...   ::...|.::|.:.|.::|.:::|.::..
Human   726 SATFTKVTTPDEHSSMLIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFK 790

  Fly  1158 -------------------------------RGGKYDVHDRELANGRRDY--PEEGGFHE----- 1184
                                           .|.:..:.:.||......|  |.|.. |.
Human   791 ENPHLIIMNVSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKN-HSGPGPC 854

  Fly  1185 -------YSQPL-DNKSAGRQSVS--------------SANKPGVESDTDSMAEYGDGDTAVATA 1227
                   |:|.. |:.|.|...||              :..|...::..:|:.|...|:|::...
Human   855 ICFENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETSLNYV 919

  Fly  1228 AARAAAAARSKLTSLPTSTQQQQQQQQQQQQQQEQPQSTSASTVPLISLASPSPSPSSTSNSPTA 1292
            :..|:.....| .||||:..:.....:.:.|....           :.||.|.|:.:|:.:|.|.
Human   920 SQLASPMFGDK-DSLPTNPVEAPHCSEYKMQMAVS-----------LRLALPPPTENSSLSSITL 972

  Fly  1293 APPSYELC 1300
            ..|....|
Human   973 LDPGEHYC 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	2/4 (50%)
		I-set	339..427	CDD:254352	12/87 (14%)
		Ig	354..427	CDD:299845	10/72 (14%)
		I-set	432..517	CDD:254352	21/86 (24%)
		Ig	446..517	CDD:299845	17/72 (24%)
		I-set	522..611	CDD:254352	12/88 (14%)
		ig	525..609	CDD:278476	10/83 (12%)
		FN3	613..707	CDD:238020	18/94 (19%)
		FN3	716..807	CDD:238020	20/133 (15%)
		fn3	817..905	CDD:278470	17/87 (20%)
		FN3	917..1004	CDD:238020	18/91 (20%)
		FN3	1041..1111	CDD:238020	21/91 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	17/150 (11%)
OSMR	NP_001310435.1	FN3	233..>288	CDD:304408	18/89 (20%)
		FN3	335..407	CDD:214495	12/71 (17%)
		WSXWS motif	416..420		1/8 (13%)
		FN3	446..522	CDD:238020	18/88 (20%)
		fn3	540..608	CDD:278470	16/80 (20%)
		FN3	626..734	CDD:238020	29/125 (23%)
		Box 1 motif	771..779		0/7 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000