DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Lifr

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_112310.1	Gene:	Lifr / 81680	RGDID:	621431	Length:	1093	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	180/884 - (20%)
Similarity:	293/884 - (33%)	Gaps:	249/884 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 PEPKISWIHNGKPIEQSTPNPRRTV----TDNTIRIINLVK---GDTGN--------YG------ 409
            |...|||..|    .::...|:..|    ::.||..|:..|   |..||        ||
  Rat   236 PLKNISWTRN----TETNVFPQDKVVLAGSNMTICCISTTKVLSGQIGNTFRPLIHLYGETVAIN 296

  Fly   410 --------CNATNSLGYVYKDVYLNV--QAEPPTISEA----------------PAAVSTVDG-R 447
                    .:.:|.:.....|||..|  ...||.:.:.                |..::.:.| |
  Rat   297 ILNIPVSENSGSNVIFSTVDDVYGTVVFAGYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPR 361

  Fly   448 NV--TIKCRVNGSPKPLVKWLRASN---WLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFG 507
            |.  |:...::|......::...:|   |||     ::...|.||.:        :|..|:|..|
  Rat   362 NTEYTLFESISGKSAVFHRFEELANETYWLT-----LKMAPDQEIHN--------FTLTARNPLG 413

  Fly   508 EIQADGSLVVKEHTRIT-QEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQ--SIDFEAQP 569
              |.:.::|:....|:. ..|.:.:|....|..            :.:.|:..|.  .|:...|.
  Rat   414 --QTESAIVINATERVALHVPISLKVKDVNSTV------------VTLSWYLPGNFTKINLVCQI 464

  Fly   570 RFVKTNDNSLTIAKTME--LDSGEYTCV----------ARTRLDEAT---------ARANLIVQD 613
            ...|.|........||.  .||..:..|          .|.|....|         .:..|..:.
  Rat   465 EICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRVRCSSETFWKWSKWSNEKRYLTTEA 529

  Fly   614 VPNAPKLTGITCQADKAE--IHWEQQGDNRS--PILHYTIQFNTSFTPASWDAAYEKVPNTDSSF 674
            .|:....|.....:|...  |:|:....|.:  .||.|.:..::|....|.....:  |...:..
  Rat   530 TPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSSEETQSLSEILD--PQHKAEI 592

  Fly   675 VVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPE 739
            .|..:   :|...|:|.|..|:||||..:.......|:   ..:..||.|   |.:.:||
  Rat   593 KVNKN---DYIISVVARNSAGSSPPSKIASMEIPNDDI---TVEQAVGIG---NRIFLSW----- 643

  Fly   740 IEHNAPNF--HYYVSWKRDIPAAAWENNNIFDW------RQNNIVIADQ-PTFVKYLIKVVAIND 795
             :|| ||.  .|.:.|..    ::|....:.||      ....::.:|| ...|:|...:....:
  Rat   644 -QHN-PNMTCDYVIKWCN----SSWSEPCLLDWIKVPSNSTGTVIESDQFQPGVRYNFYLYGCTN 702

  Fly   796 RGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTEN 860
            :|..  .....:||..|..|:.|| |||:.. ||:.|..:.|..:..|.:||..:||   .:...
  Rat   703 QGYQ--LLRSTIGYIEELAPIVAP-NFTVED-TSADSILVKWDDIPVEELRGFLRGY---LFYFQ 760

  Fly   861 EGEEGLREIHVKGDTHNALVTQFKPD-SKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLD 924
            :||....:......:|:.:..:...| |:...||                        :.:||..
  Rat   761 KGERDTPKTRSLETSHSDIKLKNITDISQKTLRI------------------------ADLQGKT 801

  Fly   925 AYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVG------------------------ER 965
            :|.|...|         |.:|.|...|..:...||:.||                        .:
  Rat   802 SYHLVLRA---------YTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRK 857

  Fly   966 REYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWE 1030
            ||:......|.:         ||.:...::.....:.|||      ..|| .:.:.|.||:.. |
  Rat   858 REWIKETFYPDI---------PNPENCKALQFQKSVCEGS------NALK-TLEMNPCTPNHV-E 905

  Fly  1031 QLPSDNGLAKFRINWLPS-TEGHPGTHFFTMHRIKGETQW---IRENEEKNSDYQEVGG------ 1085
            .|.|.:...|.....:.| ....||....|....:....:   |.|.|..|....|.||
  Rat   906 VLESRSIPPKIEDTEITSPVSERPGESSETDPENQAAVSYCPPIIEEEITNPAADEAGGASQVVY 970

  Fly  1086 LDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVA 1124
            :|.::.|:.:.          .|..|.||:    |:|||
  Rat   971 IDVQSMYQPQA----------KAEDEQDTD----PVMVA 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476
		I-set	339..427	CDD:254352	20/89 (22%)
		Ig	354..427	CDD:299845	20/89 (22%)
		I-set	432..517	CDD:254352	19/106 (18%)
		Ig	446..517	CDD:299845	17/76 (22%)
		I-set	522..611	CDD:254352	19/112 (17%)
		ig	525..609	CDD:278476	17/106 (16%)
		FN3	613..707	CDD:238020	22/97 (23%)
		FN3	716..807	CDD:238020	20/99 (20%)
		fn3	817..905	CDD:278470	21/88 (24%)
		FN3	917..1004	CDD:238020	18/110 (16%)
		FN3	1041..1111	CDD:238020	14/79 (18%)
		Bravo_FIGEY	1155..>1221	CDD:290593
Lifr	NP_112310.1	FN3	332..>368	CDD:304408	5/35 (14%)
		FN3	432..526	CDD:238020	17/105 (16%)
		WSXWS motif	515..519		0/3 (0%)
		fn3	<552..615	CDD:278470	16/67 (24%)
		FN3	725..817	CDD:238020	27/128 (21%)
		Box 1 motif	865..873		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	908..941		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1003..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000