DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrg and USH2A

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:1309 Identity:264/1309 - (20%)
Similarity:421/1309 - (32%) Gaps:435/1309 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KGNRPPRITK-------------QP--APGELLFKVAQQN--------------KESDNPF---- 55
            :|..||..||             :|  :.|.:::.:..:|              ||...||    
Human  3500 QGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYS 3564

  Fly    56 ----------------IIECEADGQPEP--------------EYSWI----KNGKKFDWQAYDNR 86
                            ::.....|.||.              ..||.    .||...::|     
Human  3565 YQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQ----- 3624

  Fly    87 MLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPF 151
             :||.|:| |:.|...|. |.|          |.|....|..    .:|...|..:......|||
Human  3625 -IRQVGKG-LIHTDTTDR-RQH----------TVTGLQPYTN----YSFTLTACTSAGCTSSEPF 3672

  Fly   152 MLKC--AAPDG---------FPSPTVN--WMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTRED 203
            :.:.  |||:|         ..|.||.  |.:.|..:|.:     |:..|...|||.|...:.|.
Human  3673 LGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLV-----SQYQLSRNGNLLFLGGSEEQ 3732

  Fly   204 ASSDFYYACSATSVFRSEYKIGNKVLLD---VKQMGVSASQNKHPPVRQYVSRRQSLALRGKRME 265
            ..:|.....::...::.|.|.|......   :.|..:|..:..:||....|....|:.:.     
Human  3733 NFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVA----- 3792

  Fly   266 LFCIYGGTPLPQ-----TVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDD-------AGTYTCD 318
              .|..|..:|:     .|...||.....:  .:.||:..:|:...|.|..       ....:|.
Human  3793 --WIPPGILIPEIPVEYNVLLNDGSVTPLA--FSVGHHQSTLLENLTPFTQYEIRIQACQNGSCG 3853

  Fly   319 VSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQST 383
            ||:.:                 |.|.||.|....:..|:   :|.|....:|.|:...||     
Human  3854 VSSRM-----------------FVKTPEAAPMDLNSPVL---KALGSACIEIKWMPPEKP----- 3893

  Fly   384 PNPRRTVTDNTIRIIN--------------------------LVKGDT------GNYGCNATNSL 416
                     |.| |||                          :.:|||      ..|...|.||.
Human  3894 ---------NGI-IINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSK 3948

  Fly   417 GYVYKDVYLNVQAE-PPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNV- 479
            |.|.....|....| ||....||.|.:| ...:|.:......||..::           ..|.| 
Human  3949 GSVESLWSLTQTLEAPPQDFPAPWAQAT-SAHSVLLNWTKPESPNGII-----------SHYRVV 4001

  Fly   480 -QANGDLEIQDVTFSD-------------------AGKYTCY-----AQNKFGEIQADGSLVVKE 519
             |...|    |.||:.                   ...:|.|     |.|..|||.:..:|:   
Human  4002 YQERPD----DPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLI--- 4059

  Fly   520 HTRITQEP---QNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTI 581
             ..:...|   :|:.|           |..::...:.:.|          ::|  ::||.    :
Human  4060 -QTLESSPSGLRNFIV-----------EQKENGRALLLQW----------SEP--MRTNG----V 4096

  Fly   582 AKTMELDSG---EYTCVAR----TRLD---------EATARAN--------LIVQDVPNAPKL-- 620
            .||..:.|.   ||:.:.|    .|||         ||..||.        |...:.|...:|  
Human  4097 IKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAP 4161

  Fly   621 TGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWD----AAYEKVPNTD-----SSFVV 676
            |..:.::...|:.|.:..:....|:.|.: ....|...:|.    .|.||:..|:     ::|:.
Human  4162 TVHSVKSTSVELSWSEPVNPNGKIIRYEV-IRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMY 4225

  Fly   677 Q---MSPWANYTFRVIAFNKIGASPPSAHSDSC-----TTQPDVPFKNPDNVVGQGTEPNNLVIS 733
            .   :.||....:::..:|..|      |:.|.     |.|......:|..:......|..|:||
Human  4226 NDTGLQPWTQCEYKIYTWNSAG------HTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLIS 4284

  Fly   734 WTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNI---FDWRQNNIVIA---DQPTFVKYLIKVVA 792
            |.| ||                       ::|.|   :..::|.::..   |..||         
Human  4285 WIP-PE-----------------------QSNGIIQSYRLQRNEMLYPFSFDPVTF--------- 4316

  Fly   793 INDRGESNVAAEEVVGYSGEDRPLDA----------PTNFTMRQ------------ITSSTSGYM 835
                   |...||::.:|.....|.|          ||:.|..:            ..|:|...:
Human  4317 -------NYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNV 4374

  Fly   836 AWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSK-NYARILAYNGR 899
            .|:|.:.::  |....|.::    .:.:|.|     .|.....||:..:|.|: |::.:...|| 
Human  4375 CWSPPTVQN--GKITKYLVR----YDNKESL-----AGQGLCLLVSHLQPYSQYNFSLVACTNG- 4427

  Fly   900 FNGPPSAVIDFD-TPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVG 963
              |..::|.... |.|.:|..:........||.:..:.||.|..|||::..|::           
Human  4428 --GCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYEL----------- 4479

  Fly   964 ERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFS 1028
             ||:.....|... ||.:...|.|..:|..::||:...|.     |....:||  ..:|:.||..
Human  4480 -RRDGTIVYTGLE-TRYRDFTLTPGVEYSYTVTASNSQGG-----ILSPLVKD--RTSPSAPSGM 4535

  Fly  1029 WEQLPSDNGLAKFRINWLP--STEGHPGTH-FFTMHRIKGETQWIRENEEKNSDYQE---VGGLD 1087
            ........|..:..:||.|  .|.|....: .|.....:.||:.|..|...||...:   |..|.
Human  4536 EPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLK 4600

  Fly  1088 PETAYEFRV 1096
            |...||.|:
Human  4601 PFHRYEIRI 4609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 21/110 (19%)
IG_like 57..127 CDD:214653 19/87 (22%)
Ig 135..214 CDD:299845 23/91 (25%)
IG_like 141..216 CDD:214653 21/87 (24%)
ig 251..332 CDD:278476 16/92 (17%)
I-set 339..427 CDD:254352 27/119 (23%)
Ig 354..427 CDD:299845 22/104 (21%)
I-set 432..517 CDD:254352 23/110 (21%)
Ig 446..517 CDD:299845 18/96 (19%)
I-set 522..611 CDD:254352 22/115 (19%)
ig 525..609 CDD:278476 21/110 (19%)
FN3 613..707 CDD:238020 20/112 (18%)
FN3 716..807 CDD:238020 18/96 (19%)
fn3 817..905 CDD:278470 21/110 (19%)
FN3 917..1004 CDD:238020 21/86 (24%)
FN3 1041..1111 CDD:238020 18/62 (29%)
Bravo_FIGEY 1155..>1221 CDD:290593
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488
EGF_Lam 517..565 CDD:238012
EGF_Lam 574..639 CDD:238012
Laminin_EGF 641..691 CDD:395007
EGF_Lam 694..733 CDD:214543
Laminin_EGF 747..795 CDD:395007
EGF_Lam 794..844 CDD:238012
EGF_Lam 847..897 CDD:214543
EGF_Lam 900..948 CDD:238012
EGF_Lam 950..1000 CDD:238012
EGF_Lam 1001..>1037 CDD:238012
fn3 1058..1132 CDD:394996
fn3 1150..1227 CDD:394996
FN3 1242..1357 CDD:238020
FN3 1368..1451 CDD:214495
LamG 1519..1678 CDD:238058
LamG 1716..1868 CDD:238058
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020 11/82 (13%)
FN3 3590..3676 CDD:238020 24/107 (22%)
FN3 3680..3767 CDD:238020 20/91 (22%)
fn3 3777..3856 CDD:394996 17/87 (20%)
FN3 3866..3960 CDD:238020 23/111 (21%)
FN3 3964..4057 CDD:238020 23/108 (21%)
fn3 4161..4247 CDD:394996 15/86 (17%)
FN3 4268..4351 CDD:238020 23/122 (19%)
fn3 4357..4428 CDD:394996 16/84 (19%)
FN3 4444..4516 CDD:238020 20/84 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541 6/24 (25%)
FN3 4529..4627 CDD:238020 22/81 (27%)
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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