DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and COL14A1

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_066933.1	Gene:	COL14A1 / 7373	HGNCID:	2191	Length:	1796	Species:	Homo sapiens

Alignment Length:	1114	Identity:	215/1114 - (19%)
Similarity:	355/1114 - (31%)	Gaps:	420/1114 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 FC-IYGGTPLPQT-----VWSKDGQRIQWSDRITQGHYG--KSLV-------IRQTNFDDAGTYT 316
            || |..|...|.|     |.|.|..:|.|  :..:|.:|  |.||       ..|.|..:  |.|
Human    22 FCTIVQGQVAPPTRLRYNVISHDSIQISW--KAPRGKFGGYKLLVTPTSGGKTNQLNLQN--TAT 82

  Fly   317 CDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQ 381
            ..:..|:...|::::     .:..:.|:.| :..|:.:..:.:......|:|::..:..|.....
Human    83 KAIIQGLMPDQNYTV-----QIIAYNKDKE-SKPAQGQFRIKDLEKRKDPKPRVKVVDRGNGSRP 141

  Fly   382 STPNPRRTV--TDNTIRIINLVKG--DTGNYGCNATN----------SLGYVYKDVYLNVQAEPP 432
            |:|...:.|  |.....|:.||.|  ..|.:......          .:|.....:.|...:..|
Human   142 SSPEEVKFVCQTPAIADIVILVDGSWSIGRFNFRLVRHFLENLVTAFDVGSEKTRIGLAQYSGDP 206

  Fly   433 TISEAPAAVSTVDG-----RNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTF 492
            .|.....|.||.|.     ||:..|               ..|.|||...|.       |.:.:|
Human   207 RIEWHLNAFSTKDEVIEAVRNLPYK---------------GGNTLTGLALNY-------IFENSF 249

  Fly   493 S-DAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQN---------------------YEVAAG 535
            . :||..|  ..:|.|.:..||    |....|....:|                     .|:|:.
Human   250 KPEAGSRT--GVSKIGILITDG----KSQDDIIPPSRNLRESGVELFAIGVKNADVNELQEIASE 308

  Fly   536 QSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRL 600
            ..:|...|.|..|.:...::..........|.|.|.:|.:.:::|...|..:.|
Human   309 PDSTHVYNVAEFDLMHTVVESLTRTLCSRVEEQDREIKASAHAITGPPTELITS----------- 362

  Fly   601 DEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYE 665
             |.|||:.:                      ::|.....|                       .|
Human   363 -EVTARSFM----------------------VNWTHAPGN-----------------------VE 381

  Fly   666 KVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNL 730
            |                   :||:.:...|.                   .||.||..||
Human   382 K-------------------YRVVYYPTRGG-------------------KPDEVVVDGT----- 403

  Fly   731 VISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAIND 795
             :|.|                                        |:.:..:..:|.|.|.||
Human   404 -VSST----------------------------------------VLKNLMSLTEYQIAVFAI-- 425

  Fly   796 RGESNVAAEEVVGYSGEDRPLDAP----------TNFTMR---QITSSTSGYM-AWTPVSEESVR 846
              .::.|:|   |..|.:..|..|          |..:||   ......|||: .:.|:: |.:.
Human   426 --YAHTASE---GLRGTETTLALPMASDLLLYDVTENSMRVKWDAVPGASGYLILYAPLT-EGLA 484

  Fly   847 GHFKGYKIQTWTENEGEEGLREIHVKGDTHNAL-VTQFKPDSKNYARILAYNGRFNGPPSAVIDF 910
            |..|..||                  |:||..: ::...|:::....:.|..|.....|  |...
Human   485 GDEKEMKI------------------GETHTDIELSGLLPNTEYTVTVYAMFGEEASDP--VTGQ 529

  Fly   911 DTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGK-LTGYKIYYEEVKESYVGERREYDPHITD 974
            :|...: ||.:.|....:||::..|.|.    |..: :.||:|.|.....:.:.| .|.||
Human   530 ETTLAL-SPPRNLRISNVGSNSARLTWD----PTSRQINGYRIVYNNADGTEINE-VEVDP---- 584

  Fly   975 PRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLA 1039
              :|...:.||.|.::|.|:|.:....|:..                |.|..|:.|::|:...|.
Human   585 --ITTFPLKGLTPLTEYTIAIFSIYDEGQSE----------------PLTGVFTTEEVPAQQYLE 631

  Fly  1040 -------KFRINWLP--STEGHPGTHFFTMHRIK------GETQWIRENEEKNSDYQEVGGLDPE 1089
                   .||:.|.|  :.||        :|::.      |:|:.:...||::|...|  ||:|.
Human   632 IDEVTTDSFRVTWHPLSADEG--------LHKLMWIPVYGGKTEEVVLKEEQDSHVIE--GLEPG 686

  Fly  1090 TAYEFRVVSV--DG--------------HFNTESATQEIDTNTVEG-------PIMVANETVANA 1131
            |.||..:::|  ||              .|.||.||..:.|.:|..       .::|.:||.::
Human   687 TEYEVSLLAVLDDGSESEVVTAVGTTLDSFWTEPATTIVPTTSVTSVFQTGIRNLVVGDETTSS- 750

  Fly  1132 GWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDY------PEEGGFHEYSQPLD 1190
                                  :|    .|:|:.|.::...|..|      |||
Human   751 ----------------------LR----VKWDISDSDVQQFRVTYMTAQGDPEE----------- 778

  Fly  1191 NKSAGRQSVSSANKPGVES---------DTDSMAEYGDGDTAVATAAARAAAAARSKLTSLPTST 1246
                  :.:.:...||.::         ||    ||....|.:.|.....:.:|..|  :||:|.
Human   779 ------EVIGTVMVPGSQNNLLLKPLLPDT----EYKVTVTPIYTDGEGVSVSAPGK--TLPSSG 831

  Fly  1247 QQQQQQQQQ 1255
            .|..:..::
Human   832 PQNLRVSEE 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	22/79 (28%)
		I-set	339..427	CDD:254352	17/101 (17%)
		Ig	354..427	CDD:299845	14/86 (16%)
		I-set	432..517	CDD:254352	23/90 (26%)
		Ig	446..517	CDD:299845	17/76 (22%)
		I-set	522..611	CDD:254352	19/109 (17%)
		ig	525..609	CDD:278476	18/104 (17%)
		FN3	613..707	CDD:238020	7/93 (8%)
		FN3	716..807	CDD:238020	16/90 (18%)
		fn3	817..905	CDD:278470	19/102 (19%)
		FN3	917..1004	CDD:238020	24/87 (28%)
		FN3	1041..1111	CDD:238020	27/93 (29%)
		Bravo_FIGEY	1155..>1221	CDD:290593	15/80 (19%)
COL14A1	NP_066933.1	FN3	32..112	CDD:238020	20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..145		4/20 (20%)
		vWA_collagen_alphaI-XII-like	157..320	CDD:238759	38/190 (20%)
		fn3	354..432	CDD:278470	28/222 (13%)
		fn3	447..516	CDD:278470	16/87 (18%)
		FN3	536..621	CDD:238020	27/111 (24%)
		FN3	630..701	CDD:214495	22/80 (28%)
		FN3	739..817	CDD:214495	20/125 (16%)
		fn3	830..908	CDD:278470	2/11 (18%)
		fn3	922..997	CDD:278470
		vWA_collagen_alphaI-XII-like	1031..1195	CDD:238759
		Nonhelical region (NC4)	1217..1458
		TSPN	1229..1424	CDD:214560
		Triple-helical region 1 (COL2)	1459..1610
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1462..1613
		Collagen	1478..1553	CDD:189968
		Collagen	1530..1608	CDD:189968
		Cell attachment site. /evidence=ECO:0000255	1607..1609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1644..1781
		Triple-helical region 2 (COL1)	1654..1779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000