DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrg and CNTN2

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:XP_024305154.1 Gene:CNTN2 / 6900 HGNCID:2172 Length:1200 Species:Homo sapiens


Alignment Length:1019 Identity:285/1019 - (27%)
Similarity:439/1019 - (43%) Gaps:119/1019 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 QSTILAALLVALLCAGSAE--SKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPE 66
            |:..|..|:|:...|.|:.  |:....|....||.  .:||    ..:.::...::.|.|...|.
Human    23 QAKALRHLVVSSPAAWSSALGSQTTFGPVFEDQPL--SVLF----PEESTEEQVLLACRARASPP 81

  Fly    67 PEYSWIKNGKKFDWQAYDNRMLRQPGR------GTLVITIP-KDEDRGHYQCFASNEFGTATSNS 124
            ..|.|..||         ..|..:||.      |.|||..| |.:|.|.|||.|||..||..|..
Human    82 ATYRWKMNG---------TEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSRE 137

  Fly   125 VYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQE-----SIDGSIKSINNS 184
            ..:|...|..|..|....::|.||...||.|..|..:|..:..|::.|     ..||       .
Human   138 AILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDG-------R 195

  Fly   185 RMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNK--HPPV 247
            .......|||:   :.|.:||....|:|.|||......|   .|.....|:.::|...:  .|.:
Human   196 HFVSQTTGNLY---IARTNASDLGNYSCLATSHMDFSTK---SVFSKFAQLNLAAEDTRLFAPSI 254

  Fly   248 RQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSK-DGQ-RIQWSDRITQGHYGKSLVIRQTNFD 310
            :.... .::.||.|:::.|.|...|.|:|:..|.| ||. ..||:..      ..:|.|...:|:
Human   255 KARFP-AETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTA------EPTLQIPSVSFE 312

  Fly   311 DAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHN 375
            |.|||.|:..|..|.......|: |.:.|.:.|......|.....:.:.|.|||.|.|.:.|:.|
Human   313 DEGTYECEAENSKGRDTVQGRII-VQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRN 376

  Fly   376 GKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPA- 439
            |:|:....   |..|....:|...|...|:|.|.|.|.|..|.:|....|.|||..|.....|. 
Human   377 GEPLASQN---RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVR 438

  Fly   440 -AVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTCYA 502
             .:....|..:.|.|:...:||.:|.|.:.:..| ...|..|..:|.|.|::::.||.|||||:|
Human   439 RLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFA 503

  Fly   503 QNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEA 567
            :|..|:..:.|.|.|::.|:||..|.:.::..|.:.|.:|:.:||.|:::...|..|...|||:.
Human   504 ENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDK 568

  Fly   568 -----QPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQA 627
                 :...||.....|||........|:|||:|:|.:|.|:..|.::|:..|..|....:....
Human   569 PGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIG 633

  Fly   628 DKA-EIHWEQQGDNRSPILHYTIQFNT---------SFTPASWDAAYEKVPNTDSSFVVQMSPWA 682
            |.. ::.|.:..||.|||..||:|..|         ...||:.:.      |.:::.|:.::||.
Human   634 DTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEG------NAETAQVLGLTPWM 692

  Fly   683 NYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNF 747
            :|.|||||.|.:|...||..|....|:...|...|..:.|.|..|..|:::||||.....|...|
Human   693 DYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGF 757

  Fly   748 HYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFV----------KYLIKVVAINDRGESNVA 802
            .|.:|::|         .....|:...:..||...||          .:.:|:.:.|.||:...:
Human   758 GYLLSFRR---------QGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPES 813

  Fly   803 AEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLR 867
            ...:| ||.|:.|..|||....:.::||... :.|.|| ::.:.|...||:|:.|...:.|....
Human   814 LTALV-YSAEEEPRVAPTKVWAKGVSSSEMN-VTWEPV-QQDMNGILLGYEIRYWKAGDKEAAAD 875

  Fly   868 EIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSA 932
            .:...|...:|.|:...|::|.:..:.|||....||.|...:..|.:..|....|..::...||:
Human   876 RVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSS 940

  Fly   933 FMLHWKKPLYP---NGKLTGYKIYYEEVKESYVGERREYDPHIT 973
            ..:.| .|:.|   ...:||||:.|:.            |.|:|
Human   941 LSIKW-DPVVPFRNESAVTGYKMLYQN------------DLHLT 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 27/79 (34%)
IG_like 57..127 CDD:214653 27/76 (36%)
Ig 135..214 CDD:299845 22/83 (27%)
IG_like 141..216 CDD:214653 21/79 (27%)
ig 251..332 CDD:278476 24/82 (29%)
I-set 339..427 CDD:254352 26/87 (30%)
Ig 354..427 CDD:299845 23/72 (32%)
I-set 432..517 CDD:254352 27/87 (31%)
Ig 446..517 CDD:299845 25/71 (35%)
I-set 522..611 CDD:254352 28/93 (30%)
ig 525..609 CDD:278476 26/88 (30%)
FN3 613..707 CDD:238020 30/103 (29%)
FN3 716..807 CDD:238020 23/100 (23%)
fn3 817..905 CDD:278470 24/87 (28%)
FN3 917..1004 CDD:238020 15/60 (25%)
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
CNTN2XP_024305154.1 Ig 49..142 CDD:325142 32/107 (30%)
Ig2_Contactin-2-like 144..241 CDD:143204 29/109 (27%)
Ig 252..337 CDD:325142 26/92 (28%)
Ig4_Contactin-2-like 341..425 CDD:143205 25/86 (29%)
Ig5_Contactin 446..518 CDD:319278 25/71 (35%)
Ig6_Contactin-2 537..616 CDD:143262 24/78 (31%)
FN3 631..718 CDD:238020 28/92 (30%)
FN3 739..813 CDD:238020 19/82 (23%)
FN3 828..920 CDD:238020 25/93 (27%)
Atrophin-1 <1002..1197 CDD:331285
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10657
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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