DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and TNN

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_016857537.1	Gene:	TNN / 63923	HGNCID:	22942	Length:	1317	Species:	Homo sapiens

Alignment Length:	1176	Identity:	212/1176 - (18%)
Similarity:	376/1176 - (31%)	Gaps:	349/1176 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 PEGNLWFSN------VTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHP--- 245
            |:|.....|      |:.|.:|...:|       ..|.|.:|.:  |..||:.|...|:.:.
Human   283 PQGLQLLKNTEDSLLVSWEPSSQVDHY-------LLSYYPLGKE--LSGKQIQVPKEQHSYEILG 338

  Fly   246 --PVRQYVSRRQSLALRGKRMELFCIYGGTPLPQ------------TVWSKDGQR----IQWSDR 292
              |..:|:     :.||..:.|:      :..||            |.|..|...    ::|.:.
Human   339 LLPGTKYI-----VTLRNVKNEV------SSSPQHLLATTDLAVLGTAWVTDETENSLDVEWENP 392

  Fly   293 ITQGHYGKSLVIR--------------------QTNFDDAG-----TYTCDVSNGVGNAQSFSII 332
            .|:..|.|   :|                    ::.:|..|     .|...|....|..:...|:
Human   393 STEVDYYK---LRYGPMTGQEVAEVTVPKSSDPKSRYDITGLHPGTEYKITVVPMRGELEGKPIL 454

  Fly   333 LNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRI 397
            ||..:      |.:..|....:.|..:...       :||            :|.:.|.|..:..
Human   455 LNGRT------EIDSPTNVVTDRVTEDTAT-------VSW------------DPVQAVIDKYVVR 494

  Fly   398 INLVKGDTGNYGCNATNSL--------GYVYKDVYL--------NVQAEPPTISEAPAAVSTVDG 446
            .....|||.....:...|.        |..|| ||:        :.:|:...::|..:..:.|..
Human   495 YTSADGDTKEMAVHKDESSTVLTGLKPGEAYK-VYVWAERGNQGSKKADTNALTEIDSPANLVTD 558

  Fly   447 RNVTIKCRVNGSP------KPLVKWLRA---------------SNWLTGGRYNVQ-------ANG 483
            |.......::..|      |.:|::..|               |..|||.|..|:       ..|
Human   559 RVTENTATISWDPVQATIDKYVVRYTSADDQETREVLVGKEQSSTVLTGLRPGVEYTVHVWAQKG 623

  Fly   484 DLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTR----ITQEPQNYEVAAGQSATFRCNE 544
            |.|.:.   :|....|        :|.:..:||....|.    ::.:|..   ||......|...
Human   624 DRESKK---ADTNAPT--------DIDSPKNLVTDRVTENMATVSWDPVQ---AAIDKYVVRYTS 674

  Fly   545 AHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANL 609
            |..:|.|:.:.                   .:.|.|:...:.........|...:.|:.:.:|:.
Human   675 AGGETREVPVG-------------------KEQSSTVLTGLRPGMEYMVHVWAQKGDQESKKADT 720

  Fly   610 IVQ-DVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP---NT 670
            ..| |:.:...|.......:.|.:.|:..   |:.|..|.:::.     ::.|....:||   ..
Human   721 KAQTDIDSPQNLVTDRVTENMATVSWDPV---RATIDRYVVRYT-----SAKDGETREVPVGKEQ 777

  Fly   671 DSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWT 735
            .|:.:..:.|...||..|.|  :.||.    .|....|:......:|.|:|......|...:||.
Human   778 SSTVLTGLRPGVEYTVHVWA--QKGAQ----ESKKADTKAQTDIDSPQNLVTDWVTENTATVSWD 836

  Fly   736 PMPEIEHNAPNFHYYVSW------KRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAIN 794
            |:     .|....|.|.:      .|::|...         .|::.|:......::|.:.|.|..
Human   837 PV-----QATIDRYVVHYTSANGETREVPVGK---------EQSSTVLTGLRPGMEYTVHVWAQK 887

  Fly   795 DRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTE 859
            ...||..|..:.      ...:|.|.|.....:|.:.: .::|.|     |:.....|.:: :|.
Human   888 GNQESKKADTKA------QTEIDGPKNLVTDWVTENMA-TVSWDP-----VQATIDKYMVR-YTS 939

  Fly   860 NEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPS---AVIDFDTPEGV-PSPV 920
            .:||  .||:.|..:..:.::|..:|..:....:.|..|......:   |..:.|.|..: ||.|
Human   940 ADGE--TREVPVGKEHSSTVLTGLRPGMEYMVHVWAQKGAQESKKADTKAQTELDPPRNLRPSAV 1002

  Fly   921 QGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYE----EVKESYVGERREYDPHITDPRVTRMK 981
            .        .|..:|.|..   |:.::.||.:.|:    .|||..:|...:           |..
Human  1003 T--------QSGGILTWTP---PSAQIHGYILTYQFPDGTVKEMQLGREDQ-----------RFA 1045

  Fly   982 MAGLKPNSKYRISI-------------TATTKMGEGSEHYIEKTTLKDAVNVAPA---------- 1023
            :.||:..:.|.:|:             |..:.:|....|..:.:.::...|.|..
Human  1046 LQGLEQGATYPVSLVAFKGGRRSRNVSTTLSTVGARFPHPSDCSQVQQNSNAASGLYTIYLHGDA 1110

  Fly  1024 -----------TPSFSWEQLPSDN-GLAKFRINWLPSTE--GHPGTHFF--------------TM 1060
                       |....|......| |...|...|....|  |.|...|:              ..
Human  1111 SRPLQVYCDMETDGGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTPAR 1175

  Fly  1061 HRIKGETQWIRENEEKNSDYQEVGGLDPE---TAYEFRVVSVDG---HFNTESATQEIDTNTVEG 1119
            :.::.:.|...|:.....|:.:|......   |..::|..:.|.   |...:..|.:.|.:
Human  1176 YEVRVDLQTANESAYAIYDFFQVASSKERYKLTVGKYRGTAGDALTYHNGWKFTTFDRDND---- 1236

  Fly  1120 PIMVANETVANAG--WFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGF 1182
             |.::|..:.:.|  |:....||                |..|:|.  :.:.:.|....|.:|
Human  1237 -IALSNCALTHHGGWWYKNCHLA----------------NPNGRYG--ETKHSEGVNWEPWKG-- 1280

  Fly  1183 HEYSQP 1188
            ||:|.|
Human  1281 HEFSIP 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845	7/29 (24%)
		IG_like	141..216	CDD:214653	7/31 (23%)
		ig	251..332	CDD:278476	18/121 (15%)
		I-set	339..427	CDD:254352	17/103 (17%)
		Ig	354..427	CDD:299845	15/88 (17%)
		I-set	432..517	CDD:254352	20/112 (18%)
		Ig	446..517	CDD:299845	18/98 (18%)
		I-set	522..611	CDD:254352	12/92 (13%)
		ig	525..609	CDD:278476	12/83 (14%)
		FN3	613..707	CDD:238020	19/96 (20%)
		FN3	716..807	CDD:238020	20/96 (21%)
		fn3	817..905	CDD:278470	18/87 (21%)
		FN3	917..1004	CDD:238020	21/103 (20%)
		FN3	1041..1111	CDD:238020	15/91 (16%)
		Bravo_FIGEY	1155..>1221	CDD:290593	10/34 (29%)
TNN	XP_016857537.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000