DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and igsf9bb

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_009293693.1	Gene:	igsf9bb / 569554	ZFINID:	ZDB-GENE-091112-15	Length:	1439	Species:	Danio rerio

Alignment Length:	1154	Identity:	253/1154 - (21%)
Similarity:	390/1154 - (33%)	Gaps:	377/1154 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 FYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVR---QYVSRRQSLALRGKRMELFC- 268
            :|.|....|||.:.               .:|:|..| .||   |:|:.|     .|:.:.|.|
Zfish     3 WYVATLIASVFSTR---------------GTAAQGAH-GVREEPQFVTSR-----AGETVILGCD 46

  Fly   269 -IYGGTPLPQTV-WSKDGQRIQW--SDRITQGH-----------YGK-SLVIRQTNFDDAGTYTC 317
             ::.....|..| |.|.|..|.:  :.|....|           :|| ||.|.:...:|.|.|.|
Zfish    47 VVHPLNGQPYVVEWFKFGVPIPFFINFRFYPPHVDPEYAGRASLHGKSSLRIERVRSEDQGWYEC 111

  Fly   318 DVSNGVGNAQSFS----IILNVNSVPYFT-KEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGK 377
            .|........:|.    :.|.||:.|.|| ..|:...|.|...:...|.|.|.|:|.:||:..|.
Zfish   112 KVLMLEQQYHTFHNGSWVHLTVNAPPTFTDTPPQYVEAKEGGSITLSCTAFGNPKPSVSWLREGN 176

  Fly   378 PIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVS 442
            |::.||   :..|:|.::.::::.:.|.|.|.|.|.:..|.......|.||. ||.|...|..::
Zfish   177 PVQDST---KYKVSDGSLTLVSISREDRGAYTCRAYSEQGEAVHTTRLLVQG-PPFIVSPPENIT 237

  Fly   443 TVDGRNVTIKCRVNGSPKPLV-KWLRASNWLTGG---------RYNVQANGDLEIQDVTFSDAGK 497
            ....::....|:....|..|. .|.    |....         |.::..:|.|.|..|...||||
Zfish   238 VNISQDAFFTCQAEAYPGNLTYTWF----WEEDNVFFKNDLKRRVSILIDGSLIISQVKPEDAGK 298

  Fly   498 YTCYAQNKFGE-IQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCN-EAHDDTLEIEIDWWKDG 560
            |||...|..|. ..|...|.|....|:...|....||.|.....||. :|:.....::  |.|||
Zfish   299 YTCSPSNSLGRPPSASAYLTVHYPARVINMPPVIYVAIGLPGYIRCPVDANPPVTSVK--WKKDG 361

  Fly   561 QSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDE--ATARANLIVQDVPNAPKLTG- 622
            ..:..|..|.:.:..|.|:.:::..|...|.||||....|..  .:..|.|:::|.|....:.|
Zfish   362 LPLRIEKYPGWSQMEDGSIRVSEVTEDSLGTYTCVPYNSLGTMGPSPPAPLVLKDPPKFLVVPGG 426

  Fly   623 -----------ITCQAD----------------------------------KAEIH--WEQQGDN 640
                       |.|:|:                                  ..|.|  ||....|
Zfish   427 EYRQEAGRELVIPCEAEGDPFPNITWRKKVGKPSRSKHNVLPRGSLQFKSLSKEDHGEWECVASN 491

  Fly   641 ---------------RSP----ILHYTIQFNTSFTPASWDAAYE--------------------- 665
                           .||    .:|.|:  :|:....|||::|:
Zfish   492 VATSITASTHLLVIGTSPHAPAKVHVTV--STTSANVSWDSSYDGGFEQTFSVWYGHVVKREQLG 554

  Fly   666 -------KVPNTDSSFVVQ-MSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDV-PFKNPDNVV 721
                   .||:.....:|| :.|...|.|.|:|.||:|..|   .|:..|....| |...|:.:|
Zfish   555 PHDWLSMPVPSGQHWLLVQGLEPETAYQFSVLAQNKLGTGP---FSEVVTVNTLVFPISTPEPLV 616

  Fly   722 ---------GQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRD---------IPAAAWENNNIF 768
                     ...|: ..::::|  :|...|.:|..||.:.::..         |||.
Zfish   617 LLTPPRCLTANRTQ-QGVLLTW--IPPANHTSPIDHYIMDFRLGERWDVLDDAIPAG-------- 670

  Fly   769 DWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAE--EVVGYSGED-------------RPL-- 816
               :..|:..|......|..:|:|:.:    ::.:|  .|||.|..|             ||:
Zfish   671 ---ETEILARDLIQEAWYEFRVMAVME----DLVSEPSNVVGVSSTDYFPPPEVPDEGLARPVVA 728

  Fly   817 -----------------------------------DAPTNFT--MRQI-TSSTSGYMAWTPVSEE 843
                                               |.|.:.|  .:.: |.|:||     .:|.|
Zfish   729 GIVATICFLAAAILFSTLAACFVNKQRRRKLKRRRDPPLSITHCRKSVETPSSSG-----KISPE 788

  Fly   844 SVRGHFKGYKIQTWTENEGEEGLR-----------EIHVKGDTHNALVTQFKPDSKNYARIL--- 894
            |:|      .|...:|: .|:|||           |:.:...|..|::::....||:.|...
Zfish   789 SIR------SIGPPSES-SEDGLRAKKFPQSPAKEELSLYKKTKRAIISKKYSVSKHEAEATTPI 846

  Fly   895 -----AYNGRFNGPPSAVIDFDTP------EGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLT 948
                 ..:|||...|:   |.:||      ||.|. |:..|.||
Zfish   847 ELISRGPDGRFVMDPT---DMETPVKARRIEGFPF-VEESDLYP--------------------- 886

  Fly   949 GYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTT 1013
                           |.|:.|....||......||.|:|:....||        ...|.|::
Zfish   887 ---------------EFRQSDEENDDPGPMPPVMATLRPHQISPIS--------SSQESYLQ--- 925

  Fly  1014 LKDAVNVAPA-TPSFSWEQLPSDNGLAKFRINWLPST---EGHPGTHFFTMHRIKGETQWIRENE 1074
                   .|| :|.|   |.|.: |:.....:.|.:|   .|.|....||..:.........|.|
Zfish   926 -------PPAYSPRF---QRPME-GMTIMETSRLQATGQIRGAPHFRAFTHGQFYSYLGSPGEPE 979

  Fly  1075 EKNSDYQEVGGLDPETAYEFRVVS-----VDGHFNTESATQEIDTNTVE 1118
            .....|.      |:|:....|:|     ::|.|...:..:||....::
Zfish   980 PPPPFYM------PDTSPLSSVMSSPPYHLEGPFGHPTIPEEIGEGEIQ 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845	2/5 (40%)
		IG_like	141..216	CDD:214653	2/7 (29%)
		ig	251..332	CDD:278476	24/101 (24%)
		I-set	339..427	CDD:254352	26/88 (30%)
		Ig	354..427	CDD:299845	20/72 (28%)
		I-set	432..517	CDD:254352	24/95 (25%)
		Ig	446..517	CDD:299845	21/81 (26%)
		I-set	522..611	CDD:254352	25/91 (27%)
		ig	525..609	CDD:278476	23/86 (27%)
		FN3	613..707	CDD:238020	34/189 (18%)
		FN3	716..807	CDD:238020	18/110 (16%)
		fn3	817..905	CDD:278470	26/109 (24%)
		FN3	917..1004	CDD:238020	16/86 (19%)
		FN3	1041..1111	CDD:238020	15/77 (19%)
		Bravo_FIGEY	1155..>1221	CDD:290593
igsf9bb	XP_009293693.1	IG_like	30..113	CDD:214653	23/87 (26%)
		Ig	41..113	CDD:143165	19/71 (27%)
		IG_like	144..223	CDD:214653	23/81 (28%)
		IGc2	151..208	CDD:197706	18/59 (31%)
		I-set	227..319	CDD:254352	24/95 (25%)
		Ig	<263..319	CDD:299845	17/55 (31%)
		Ig_2	326..414	CDD:290606	24/89 (27%)
		IG_like	329..403	CDD:214653	22/75 (29%)
		IG_like	424..504	CDD:214653	9/79 (11%)
		Ig	440..504	CDD:299845	7/63 (11%)
		FN3	509..604	CDD:238020	23/99 (23%)
		FN3	620..704	CDD:238020	16/101 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910