DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and nfascb

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_005162159.1	Gene:	nfascb / 559590	ZFINID:	ZDB-GENE-100519-2	Length:	1166	Species:	Danio rerio

Alignment Length:	1286	Identity:	373/1286 - (29%)
Similarity:	565/1286 - (43%)	Gaps:	232/1286 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WRQSTILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPE 66
            ||...|:..|....:.|........:||.|.|:.....::..|        :|.|:||||.|.|.
Zfish     4 WRIPVIITVLQQTWILAMEIPPDVRQPPMIYKESVQDYIVDPV--------DPIIVECEATGNPP 60

  Fly    67 PEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITI--PKDEDRGHYQCFASNEFGTATSNSVYVRK 129
            |.::|.:||...: .|.|.::..:...|||.|..  ..|:..|.|||.|:||||||.|:.:.:|.
Zfish    61 PVFTWTRNGVYLN-VARDPQVSMRWRSGTLEIFFWGRPDDYEGIYQCTATNEFGTALSSYINLRV 124

  Fly   130 AELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPE-GN 193
            ::...:..|..:.:..|.|.|.:|.|..|:|.|.|...|     ::.::..|...|.....| |:
Zfish   125 SKARTWLKEYLEPVTVVVGLPLILPCNPPEGPPKPDTYW-----LNSTMSPIRQDRRVSKSENGD 184

  Fly   194 LWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQS-- 256
            |:||::..:||.::  |.|.|...|                  .:..|.|.|.:.|.::.|.:
Zfish   185 LYFSSIVADDALTN--YVCVARFPF------------------TNTIQQKPPLILQVLTARMAAH 229

  Fly   257 ---------------LALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQ 306
                           :|:.|:.:.|.|...|.|.|...|:||.:.:..:.:..: ::.|:|.|::
Zfish   230 TAPKFLKPKGTASTRIAMLGEELILECFAAGVPTPSIKWTKDYEEMTMTGKKLE-NFNKTLRIKK 293

  Fly   307 TNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKIS 371
            ...||.|.|.|..||.:|:.... |.:.|.|||::.::||....:.|:.....|||.|:|.|:|.
Zfish   294 IAMDDGGDYICTASNRMGSLDHI-ITVRVKSVPFWLEKPESLVLSRDDGGSMVCRADGIPRPQIQ 357

  Fly   372 WIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNV-QAEPPTIS 435
            |:.||:||..:..:|.|.|:.:|:....:|......:.|||:|..||:..:.:|.| ..:|..:.
Zfish   358 WLVNGEPISDAPRSPGRQVSGDTLTFRGVVPDSAAVFQCNASNPYGYIMTNAFLAVMDMKPRLLG 422

  Fly   436 EAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRAS-NWLTGGRYNVQANGDLEIQDVTFSDAGKYT 499
            .......|.:|....:.|...|||||:::|.:.. ..|.||||....||.|||::....|.|.|.
Zfish   423 PRDELFKTTEGNLTLLDCPYFGSPKPVLRWSKGGVGTLEGGRYRTLPNGTLEIRNTKLQDQGAYV 487

  Fly   500 CYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSID 564
            |.|.|..|..:.:..|.|||..:|.:.|.|..|..|..|.|.|....|.:|::.:.|.||.:
Zfish   488 CVASNVIGRDEKEVQLEVKEPIKIIRAPHNTVVIRGSLARFDCKIKFDTSLDVTVTWLKDKK--- 549

  Fly   565 FEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADK 629
            |....|.:..::.||:||.....|.|.|||..::.|:|.|..|.|.|.|.|:.|....|:..:::
Zfish   550 FLILGRRMTKDEESLSIADVYRRDEGVYTCRVKSELEEVTTSAKLTVMDRPDPPTDLEISDPSER 614

  Fly   630 A-EIHWEQQGDNRSPILHYTIQFNTS------FTPASWD--AAYEKVPNTDSSFVVQMSPWANYT 685
            : .:.|.....|.|||..|.||:..:      ..|:.|.  .:|   |.:.:|.::|::|:..||
Zfish   615 SVRLTWTPGLSNHSPIKEYLIQYTENLLADYWLLPSGWKNLTSY---PGSLNSVILQLTPFVEYT 676

  Fly   686 FRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNV--VGQGTEPNNLVISWTPMPEIEHNAPNFH 748
            |||||.|.||.|.||..|:...|...||...|.|:  :|.|...||:.|||.|:...|.|.|...
Zfish   677 FRVIAVNGIGPSKPSWASEYYQTGGAVPDAIPRNIQGLGYGVFRNNMEISWEPLEYREWNGPKLG 741

  Fly   749 YYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRG---ESNVAAEEVVGYS 810
            |.|.|:|......|:|...:.|  .:.:|.|..||..|.|||.|||..|   ||.|    |:|||
Zfish   742 YMVWWRRRDSREEWKNYTTYWW--CSTIIYDTDTFTPYEIKVQAINFFGYGPESPV----VIGYS 800

  Fly   811 GEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENE---GEEGLREIHVK 872
            |||||:.||:..::..|.|:|. .:.|.||:...:.|..|.||:..|.|:.   .....|.|..|
Zfish   801 GEDRPVAAPSELSVSDIESTTL-TVHWEPVARADIMGEIKEYKVYYWRESSRLPWHVVTRRIKTK 864

  Fly   873 -----GDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSA 932
                 |...:..:|...|.|.....|:..|.|:.||||..|:|.||||||:..:...........
Zfish   865 SFKANGPRLSGTLTGLVPFSNYKMYIVVANNRYEGPPSHNIEFQTPEGVPTIPRSFRIMHRHYDT 929

  Fly   933 FMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITA 997
            ..|.|::|..|||.||||.:.|:.:..| ||.:.|..|    |.:|...:..|...::|:.|:.|
Zfish   930 LYLDWEEPAEPNGVLTGYILKYQSLNVS-VGIQVENIP----PNITYFSLRRLDRYTRYKFSLAA 989

  Fly   998 TTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHR 1062
            .|::|.|...                                         ||..|
Zfish   990 QTEVGVGEAF-----------------------------------------TEESP--------- 1004

  Fly  1063 IKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQ-EIDTNTVEGPIMVANE 1126
                                                   ||.||..|: ::|
Zfish  1005 ---------------------------------------HFTTEEYTRDQVD------------- 1017

  Fly  1127 TVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHD-RELA------NGRRDY-------- 1176
             :...|||||:|.|:|.::::.:|:..|:|:|||||.|.| ::.|      ||..||
Zfish  1018 -IVTQGWFIGLMCAVALLVLIMLIVFFIKRSRGGKYPVRDNKDFALEPMDENGTFDYRSLERITR 1081

  Fly  1177 ----PEEGGFHEYSQPLDNKSAGRQ--SVSSANKPGVESDTDSMAEYGDGD 1221
                |       ||:..:....||.  ::...|: ...|| ||:.|||:|:
Zfish  1082 VSTIP-------YSRREEESRQGRSQGAIEHINR-RTNSD-DSLMEYGEGE 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	30/74 (41%)
		IG_like	57..127	CDD:214653	29/71 (41%)
		Ig	135..214	CDD:299845	22/79 (28%)
		IG_like	141..216	CDD:214653	22/75 (29%)
		ig	251..332	CDD:278476	22/97 (23%)
		I-set	339..427	CDD:254352	28/87 (32%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	27/85 (32%)
		Ig	446..517	CDD:299845	26/71 (37%)
		I-set	522..611	CDD:254352	29/88 (33%)
		ig	525..609	CDD:278476	27/83 (33%)
		FN3	613..707	CDD:238020	33/102 (32%)
		FN3	716..807	CDD:238020	35/95 (37%)
		fn3	817..905	CDD:278470	26/95 (27%)
		FN3	917..1004	CDD:238020	25/86 (29%)
		FN3	1041..1111	CDD:238020	8/70 (11%)
		Bravo_FIGEY	1155..>1221	CDD:290593	26/86 (30%)
nfascb	XP_005162159.1	Ig	49..123	CDD:353325	30/74 (41%)
		Ig	130..220	CDD:353325	27/114 (24%)
		Ig	252..322	CDD:353325	20/71 (28%)
		Ig	342..413	CDD:353325	24/70 (34%)
		Ig	438..502	CDD:319273	24/63 (38%)
		I-set	510..596	CDD:336764	29/88 (33%)
		FN3	600..691	CDD:238020	29/93 (31%)
		FN3	721..799	CDD:238020	32/83 (39%)
		FN3	808..909	CDD:238020	30/101 (30%)
		FN3	914..1008	CDD:238020	31/187 (17%)
		Bravo_FIGEY	1045..1141	CDD:316405	27/88 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920