DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and nrcama

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_005164693.1	Gene:	nrcama / 556537	ZFINID:	ZDB-GENE-041210-235	Length:	1324	Species:	Danio rerio

Alignment Length:	1314	Identity:	405/1314 - (30%)
Similarity:	606/1314 - (46%)	Gaps:	196/1314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQP 91
            :||.||.| :|.:.:.    ..:|:.|.|   |||.|:|.|.:||.:||..||.:. |.:::..|
Zfish    44 QPPTITNQ-SPKDYII----DPRENINIF---CEAKGKPHPSFSWTRNGTHFDVEK-DPKVVMMP 99

  Fly    92 GRGTLVITIPKDED---RGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFML 153
            |.|.|||.|..::.   .|.|||.|.||.|:|.||::.:|::....:..|..:.:....|...:|
Zfish   100 GTGNLVIDISGEKAEVYEGVYQCIARNEHGSAVSNNIVIRQSRSPLWSKEKNEPITVQRGTSLIL 164

  Fly   154 KCAAPDGFPSPTVNWMIQESIDGSIKSI-NNSRMTLDPEGNLWFSNVTREDASSDFYYACSA--- 214
            :|..|.|.|.|.:.||     |.:.:.: .|||::....|:|:||||..||..:|  |.|.|
Zfish   165 QCRPPAGLPPPIIFWM-----DNNFQRLPQNSRVSQALNGDLYFSNVIMEDTRND--YICYARFP 222

  Fly   215 -TSVFRSEYKIGNKVLLDVKQM---------------GVSASQNK-----HPPVRQYVSRRQSLA 258
             |...:.:..|..|| ||::.|               |.|.|..:     |||..:    ..::.
Zfish   223 HTQTIQQKQPITVKV-LDIEAMNDTVLAAFLNGSDFWGDSPSGERVPSFLHPPGME----STTMV 282

  Fly   259 LRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGV 323
            |:|..:||.||..|.|.|...|:|....:. |.|.:...:.|:|.|::....|.|.|.|...|.:
Zfish   283 LKGDTLELECIADGLPTPNISWTKVNGELP-SGRFSFYSFQKTLKIKEVTEADGGDYRCIAKNRM 346

  Fly   324 GNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRR 388
            |::| .:|.:.|.:.|::...|:....|..|.....|...|.|:|.|:|..||.|||.|..:|.|
Zfish   347 GSSQ-HTITVVVRAAPFWISAPQNLILAPKETGNLTCDVDGNPKPTITWSVNGNPIESSHNDPSR 410

  Fly   389 TVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPP-TISEAPAAVSTVDGRNVTIK 452
            .|:|..|.:.::..|.:..|.|||:|..||:..:.:::|.|||| .::......|.:......:.
Zfish   411 KVSDGVITLSDVQTGSSAVYQCNASNDYGYLLANAFVSVLAEPPRVLTSLNHEYSVISNSRALLD 475

  Fly   453 CRVNGSPKPLVKWLRAS-NWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLV 516
            |...|||.|.:.|.:.| :.|....|::..||.|||......::|||||.|.|..|..:....|.
Zfish   476 CASFGSPLPKITWFKDSQSILNSDLYHIHKNGTLEINVAQPQNSGKYTCIASNNLGNKENHVHLQ 540

  Fly   517 VKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKD-GQSIDFEAQPRFVKTNDNSLT 580
            |||.|||.::|:..||.....|.|.|...||.||...:.|.|| |:..|   .||| :...:|||
Zfish   541 VKEPTRIIRQPEYKEVQRNSIAVFECKVKHDPTLIPSMIWLKDNGELPD---DPRF-EVGSDSLT 601

  Fly   581 IAKTMELDSGEYTCVARTRLDEATARANLIVQDV----------PNAPKLTGITCQADKA-EIHW 634
            |....|.|.|.|||:..|.||:.:|.|.|.|.:.          |:.|....:|.|.::: .:.|
Zfish   602 IHDVTEDDEGTYTCIRNTTLDQDSASATLTVVEATPTPTMILEQPDPPTDLELTDQRERSVRLTW 666

  Fly   635 EQQGDNRSPILHYTIQFNTSF-TPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASP 698
            ....::.|||..:.||:..|. .|..| ....:|..|.::..:::||:..|:|||:|.|.:|.|.
Zfish   667 TPGDEHNSPIKLFLIQYEDSLHEPGVW-LNMTEVSGTSTTAQLELSPYVYYSFRVLALNGVGLSE 730

  Fly   699 PSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWK-RDIPAAAW 762
            .|..|....|.|..|..||.:|...||.|:.:.|||..:..:|.|.|...|.|||: :|  |..|
Zfish   731 SSDPSRQYRTNPAKPDVNPSDVEVSGTSPDTMTISWRELSGLESNGPGLQYKVSWRMKD--AEQW 793

  Fly   763 ENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQI 827
            ....:.:..|:  |:...|||..|.:.|.|:||.|| ....|.|:|||||:.|..||.|..: .:
Zfish   794 TTVTLANVSQH--VVTGTPTFTLYEVTVQAVNDYGE-GPRPEVVLGYSGENSPTVAPENVKV-SV 854

  Fly   828 TSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKG-DTHNALVTQFK------- 884
            .|.|...:.|..|...||||..||||: |:      :.:|.:|.:. |..|..|..|.
Zfish   855 QSGTEAEVHWEAVPLSSVRGRLKGYKV-TY------QKMRSLHKQDYDRENPQVLIFSGEETVGR 912

  Fly   885 -PDSKNYA----RILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPN 944
             ||...|:    .|.|:||..:||.|....|.||||||.|...::...|...:.::.|..||..|
Zfish   913 LPDLHPYSHYRLNIRAFNGHGDGPSSTDQQFQTPEGVPGPPTNVNIRNLNLDSLLVEWTPPLEDN 977

  Fly   945 GKLTGYKIYYEEVKES-YVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEG---- 1004
            |.||||.:.|:.:..: ..|..:|.   :.....|...:..|..::.|:..:.|.|:.|.|
Zfish   978 GHLTGYLLKYQPINTTEEAGLLKEV---LLPANETSYTLDKLTHSTHYKFFLNAMTETGSGPAVT 1039

  Fly  1005 SEHYIE-----------------------------KTTLKDAVNVAPATPSF------------- 1027
            .|.:.|                             ..:|:......||.|.|
Zfish  1040 KEAFTEVDEALIRHPAVEAGKGSAPPSPPPPTPPVTQSLQPPFQAPPAGPMFGNVNSSVKEDHAV 1104

  Fly  1028 -SWEQL-PSDNGLAKFRIN-----WLPSTEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGG 1085
             |||.| |..|...::.::     |  .||...||..|                       ::.|
Zfish  1105 ISWEYLGPDGNVYVEYVVDNSKEPW--KTEFVNGTRTF-----------------------QIRG 1144

  Fly  1086 LDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANET-VANAGWFIGMMLALAFIIILFI 1149
            |.|..:|..|:|:.|....|..:|||:   .:..|.|...:. :|..|||||:|.|:|.:|::.:
Zfish  1145 LKPGMSYRVRLVAKDHSDATIHSTQEM---LITVPAMTNRQAEIATQGWFIGLMCAIALLILVLL 1206

  Fly  1150 IICIIRRNRGGKYDVHDRELANGRRDYPE-------EGGFHEYSQPLDNKS-AGRQSVSSANKPG 1206
            |:|.|:||:||||.|.::|  :..:| ||       :|.|.|||...|:|. .|.::.|:.....
Zfish  1207 IVCFIKRNKGGKYPVKEKE--DAHQD-PEIQPMKEDDGTFGEYSDTEDHKPLKGSRTPSNGTVKK 1268

  Fly  1207 VESDTDSMAEYGDG 1220
            .:|| ||:.:||:|
Zfish  1269 DDSD-DSLVDYGEG 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	32/75 (43%)
		IG_like	57..127	CDD:214653	31/72 (43%)
		Ig	135..214	CDD:299845	25/79 (32%)
		IG_like	141..216	CDD:214653	25/79 (32%)
		ig	251..332	CDD:278476	23/80 (29%)
		I-set	339..427	CDD:254352	29/87 (33%)
		Ig	354..427	CDD:299845	26/72 (36%)
		I-set	432..517	CDD:254352	25/86 (29%)
		Ig	446..517	CDD:299845	23/71 (32%)
		I-set	522..611	CDD:254352	36/89 (40%)
		ig	525..609	CDD:278476	33/84 (39%)
		FN3	613..707	CDD:238020	27/105 (26%)
		FN3	716..807	CDD:238020	32/91 (35%)
		fn3	817..905	CDD:278470	31/100 (31%)
		FN3	917..1004	CDD:238020	21/87 (24%)
		FN3	1041..1111	CDD:238020	15/74 (20%)
		Bravo_FIGEY	1155..>1221	CDD:290593	27/74 (36%)
nrcama	XP_005164693.1	IG_like	53..134	CDD:214653	33/88 (38%)
		Ig	64..139	CDD:299845	33/78 (42%)
		Ig	144..236	CDD:299845	28/98 (29%)
		IG_like	152..237	CDD:214653	27/91 (30%)
		IG_like	278..357	CDD:214653	24/80 (30%)
		Ig3_L1-CAM_like	288..358	CDD:143208	22/71 (31%)
		I-set	361..449	CDD:254352	29/87 (33%)
		Ig4_L1-NrCAM_like	376..450	CDD:143179	26/73 (36%)
		IG_like	464..541	CDD:214653	24/76 (32%)
		IGc2	468..531	CDD:197706	21/62 (34%)
		I-set	546..632	CDD:254352	36/89 (40%)
		Ig	562..632	CDD:299845	31/73 (42%)
		FN3	646..736	CDD:238020	26/90 (29%)
		FN3	748..834	CDD:238020	32/90 (36%)
		fn3	846..938	CDD:278470	31/99 (31%)
		FN3	950..1044	CDD:238020	23/96 (24%)
		fn3	1096..1157	CDD:278470	17/85 (20%)
		Bravo_FIGEY	1212..1300	CDD:290593	27/74 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10316
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21041
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1108
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm24295
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.880