DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and cntn3b

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_684096.6	Gene:	cntn3b / 556251	ZFINID:	ZDB-GENE-130530-645	Length:	1029	Species:	Danio rerio

Alignment Length:	1037	Identity:	282/1037 - (27%)
Similarity:	469/1037 - (45%)	Gaps:	80/1037 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQ---STILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEAD 62
            :|::   .:|:..|.|:|..|..|:..|   |...::|.  :|:..:....:|:    ::.|||.
Zfish     4 LWKRLVALSIIGCLAVSLAQAEDAKFSG---PSWKREPE--DLILPIYSPQQEA----VLSCEAS 59

  Fly    63 GQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVIT-IPKDEDRGHYQCFASNEFGTATSNSVY 126
            |.|.|:|.|..||...|....:.|.|   ..|.|:|| :.:|:|.|.|||.|.|..||..|....
Zfish    60 GAPSPQYRWSLNGTLIDLGGDERRRL---SGGNLIITGLDRDQDSGVYQCTAFNTRGTILSQRAT 121

  Fly   127 VRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPE 191
            ::.|.|..||.:....:...||:..:|.|..|......|..|:..|.  ......::.|......
Zfish   122 LQFAYLENFKTQTRSAVNVREGQGVVLLCGTPLHSGELTFTWVFNEY--PHFVQQDSRRFVSQET 184

  Fly   192 GNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRRQS 256
            |||:.:.|...|..:   |.|...:....|....:...|.::..|   :..::.|..:.......
Zfish   185 GNLYIAKVEPSDVGN---YTCVVNNTITKERVFSSPTPLVLRNDG---AMGEYEPKIELHFPDTI 243

  Fly   257 LALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSN 321
            .|.:|..::|.|...|.|:|:..|.:... :.:.:::...:....|.|.....:|.|||.|...|
Zfish   244 PAAKGSALKLECFALGNPVPRISWRRTSD-VSFPNKVKLKNSNAILEIPSFQQEDTGTYECIAEN 307

  Fly   322 GVG-NAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPN 385
            ..| ||....:  :.::.|::.:.......:.:|.:.:||:|.|.|:|..||:.||   |.....
Zfish   308 SRGKNAARGRV--SFHATPHWLQTMTDTAMSIEENLFWECKANGKPKPSYSWLKNG---ESLISE 367

  Fly   386 PRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAA--VSTVDGRN 448
            .|..:.:..:.|.:|...|.|.|.|.|.|..|.:|....|.|.|..|:.|:.|.:  :....|.:
Zfish   368 GRVQIENGALSIFSLNLSDGGMYQCVAENKHGIIYSSAELMVLASAPSFSQNPLSQTLKARSGSD 432

  Fly   449 VTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQAD 512
            |::.||.:.||:.:..|.|.:..| ...|..:..||.|:|.::|..|.|.|||.|:|:||.....
Zfish   433 VSLDCRPHASPRAISLWKRGTEILQRNERTFLFPNGTLKITNITKRDGGSYTCVAKNQFGTASTT 497

  Fly   513 GSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDN 577
            |.|::.|.|||:|.|.:.|:..|:|....|....|..|::...|..:||.|||.......:....
Zfish   498 GKLIITEPTRISQSPSSTEITVGESVVLPCQVTADPALDVAFSWAFNGQPIDFHQDADHFERVGG 562

  Fly   578 SLT---IAKTMELD-SGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADK-AEIHWEQQ 637
            |.:   :.:.::|: .|:|.|:..|.::..:|.|.|:|:..|:.|.:..:....|. |::.|...
Zfish   563 SFSGDLMIRNIQLNHGGKYVCLVDTDVESLSADAILVVKGPPSPPDMVVVEEVTDSTAQLSWSPG 627

  Fly   638 GDNRSPILHYTIQFNTSFTPASWDAAYEKVP-----NTDSSFVVQMSPWANYTFRVIAFNKIGAS 697
            .||.|||..|.||..|.|| ..|.|. :.||     ||.::.||.::.|..|.|||:|.|.:|..
Zfish   628 QDNGSPITGYAIQGRTPFT-VGWQAV-DTVPEVINGNTLTATVVGLNAWVEYEFRVLASNSVGMG 690

  Fly   698 PPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHY--------YVSWK 754
            .||..|....|:..:|...|.:|.|.|...:.|||:|.|:||...|...|.|        .|:|.
Zfish   691 EPSPPSTKIRTEDSMPDAAPTDVGGGGGTKSELVITWEPVPEELQNGEGFGYIIAFRPVGMVTWT 755

  Fly   755 RDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAP 819
            |.:.:|......:|   :|:.:    |.|..:.:||.|.|:|||...:....| :|.|:.|..||
Zfish   756 RVVISAPSLTRYVF---RNDTI----PPFSPFNVKVGAFNNRGEGPFSTIATV-FSAEEVPSIAP 812

  Fly   820 TNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFK 884
            ...:.:.: |:....:.|.|::  |:.....||::..|.::...:.:.::.:.|:.....|:..:
Zfish   813 EKVSAKSL-SAADIEVTWEPIA--SIPERVLGYEVVYWEDDTKPDTVGKVRITGNYTAVNVSGLQ 874

  Fly   885 PDSKNYARILAYNGRFNGPPSAVIDFDTPEGVP-SPVQGLDAYPLGSSAFMLHWKK--PLYPNGK 946
            .:::.|..:.|:|....||.||.::..|.:..| .|.|.::...:||. .:|.|..  .|....:
Zfish   875 GNTQYYLAVCAFNTAGTGPQSAPVNITTKKPPPGQPPQNVEWNLIGSQ-LILQWDPVIALETESE 938

  Fly   947 LTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTK--MGEGSE 1006
            :|||.:.|.        ..|..|.:......|..::. |.||..|.|.|.:.::  :|||||
Zfish   939 VTGYIVLYR--------RHRNNDMYSIITNKTSAELT-LNPNDNYVIQIKSLSEGGLGEGSE 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	28/73 (38%)
		IG_like	57..127	CDD:214653	28/70 (40%)
		Ig	135..214	CDD:299845	18/78 (23%)
		IG_like	141..216	CDD:214653	16/74 (22%)
		ig	251..332	CDD:278476	19/81 (23%)
		I-set	339..427	CDD:254352	25/87 (29%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	29/87 (33%)
		Ig	446..517	CDD:299845	26/71 (37%)
		I-set	522..611	CDD:254352	25/92 (27%)
		ig	525..609	CDD:278476	22/87 (25%)
		FN3	613..707	CDD:238020	35/99 (35%)
		FN3	716..807	CDD:238020	29/98 (30%)
		fn3	817..905	CDD:278470	16/87 (18%)
		FN3	917..1004	CDD:238020	22/91 (24%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
cntn3b	XP_684096.6	Ig	31..121	CDD:299845	33/101 (33%)
		IG_like	50..115	CDD:214653	27/71 (38%)
		Ig	126..220	CDD:299845	20/98 (20%)
		Ig	233..321	CDD:299845	20/90 (22%)
		IG_like	240..311	CDD:214653	16/71 (23%)
		I-set	324..409	CDD:254352	25/87 (29%)
		Ig	326..409	CDD:299845	24/85 (28%)
		IG_like	422..502	CDD:214653	26/79 (33%)
		Ig	430..502	CDD:299845	26/71 (37%)
		I-set	507..600	CDD:254352	25/92 (27%)
		Ig	521..604	CDD:299845	20/82 (24%)
		FN3	604..701	CDD:238020	35/98 (36%)
		FN3	709..801	CDD:238020	29/98 (30%)
		FN3	811..902	CDD:238020	18/93 (19%)
		FN3	921..995	CDD:238020	22/81 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810