DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and cntn1b

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001014814.1	Gene:	cntn1b / 541474	ZFINID:	ZDB-GENE-041210-236	Length:	1031	Species:	Danio rerio

Alignment Length:	1068	Identity:	276/1068 - (25%)
Similarity:	434/1068 - (40%)	Gaps:	151/1068 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLVALLCAGSAESKGNRP----PRITKQPAPG-------ELLFKVAQQNKESDNPFIIECEADG 63
            |:|::|.......:...:|    |||..:.|.|       |.|..|..:: ..:|...:.|....
Zfish     7 AMLLSLFSCFFLLAAAIKPRIFEPRIFDKEATGFGPIFEEEPLDTVYAED-SPENKISMNCRVRA 70

  Fly    64 QPEPEYSWIKNGKKFDWQAYDNRMLRQPGR------GTLVITIP-KDEDRGHYQCFASNEFGTAT 121
            .|.....|..|    :||.   :::.||..      |.||||.| |::..|.|.|.|.|.:||..
Zfish    71 NPPAIIKWWLN----NWQI---KLMEQPDEHFSLVGGNLVITNPEKNKHAGKYVCVAKNVYGTVM 128

  Fly   122 SNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTV-NWMIQESIDGSIKSINNSR 185
            |....|:...||.|..:..:.:...||:..:|.|..|..:|...: .|:..:..:..|.  :..|
Zfish   129 SKEANVKFGYLNQFPTDEREPVNVKEGQGAVLLCTPPSRYPDEVMFRWIYNDFPNFIIP--DQRR 191

  Fly   186 MTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQY 250
            ......|||:.:.|...|..:   |:|     |.|...||..|.    .|.::........|::|
Zfish   192 FVSQSTGNLYIAKVEPSDVGN---YSC-----FVSSPTIGKSVF----SMPIALIPQIEKEVKRY 244

  Fly   251 -----VSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFD 310
                 |...::.||..:.:.|.|...|.|||...|.|....:..:..::..  |..|.:....::
Zfish   245 PADIRVKFPKTYALVHQNITLECFALGNPLPHIRWRKLDADLPPNYEVSMN--GALLHLINVQYE 307

  Fly   311 DAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTK------EPEIATAAED------EEVVFECRAA 363
            |.|:|.|:.             |||..:.::.:      .||.|....|      .|:...|.|.
Zfish   308 DEGSYECET-------------LNVKGMDWYRQWLYVEGPPEWAEHINDTEKDVGSELTLRCVAV 359

  Fly   364 GVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQ 428
            |.|.|.|.|:.:|           .:.....::..:|...|:|.|.|.|.|..|.:|.:..|.|.
Zfish   360 GKPIPWIRWLKDG-----------YSYGKGELKFSSLTFEDSGMYQCIAENEWGTIYANAELRVV 413

  Fly   429 AEPPTISEAPAAVSTVDGRN--VTIKCRVNGSPKPLVKWLRASNWLT-GGRYNVQANGDLEIQDV 490
            :..||....|.....:...|  |.|:|....:|||...|.|.|..|: ..|..:..:|.|||.:.
Zfish   414 SCAPTFIYNPVKKILLGAENGRVVIECNPRAAPKPRFIWKRGSELLSNSSRIFIWDDGSLEILNA 478

  Fly   491 TFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEID 555
            |.||.|.|||||:|..|:..:.|:|.:.|.|:||..|.|.|.|.|.:...:|:.::|.:|::...
Zfish   479 TKSDEGSYTCYAENDRGKSNSTGTLTITEATKITVGPSNSEAAVGDTIVLQCSASYDPSLDVTFI 543

  Fly   556 WWKDGQSIDFEAQPRFVK-----TNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVP 615
            |..|..||:|.......:     .|...|.|.......:|.|.|.|:|.:|.|||.|::.|:.:|
Zfish   544 WTVDSYSINFYTDFEHYELDMDHENSGDLLIKNIQIRHAGHYICTAQTIVDNATAEADVFVRGLP 608

  Fly   616 NAPKLTGITCQA---DKAEIHWEQQGDNRSPILHYTIQFNTSFT--PASWDAAYEKVP-----NT 670
            ..|  .|:..:.   ...:|.|....|:.||::.:.:|....:.  |..|..| ...|     :|
Zfish   609 GPP--GGVRVEEIGDTSVKIRWCLGSDHGSPLIQHIVQTRDFYALDPEDWKTA-TTTPAFLNGST 670

  Fly   671 DSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWT 735
            :|:.||.:.||..|.|||.|.|:.||...|..|....|....|...|.:|:||......|:::|.
Zfish   671 ESATVVDLYPWMQYEFRVHAINEFGAGENSRPSIKIKTWDARPTVAPSDVIGQVGISGELIVTWN 735

  Fly   736 PMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYL------------I 788
            |:.........|.|.|::|:         :..::|:.:.:   :.|...:|:            |
Zfish   736 PVKPQFFFGKKFGYVVAFKQ---------HEDYEWKWSTV---EDPETRRYVYKESMTPDTEIQI 788

  Fly   789 KVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYK 853
            ||...|::||...:...|| ||....|.:||.:...||:| ||...:.|.||.:.... ...||:
Zfish   789 KVSTFNNKGEGPASLISVV-YSPRIAPTEAPLDVYARQVT-STEALVWWLPVYQAPPM-WVDGYQ 850

  Fly   854 IQTWTE-NEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVP 917
            |:.|.: ::.|.....:.|....:...:...:|||.....:.|:||...||||...:..|..  |
Zfish   851 IRYWRKYDDNEAAASRVIVHRTVNQTRLENMRPDSHYLIEVRAFNGAGLGPPSEHCEMFTRR--P 913

  Fly   918 SPVQGLDAYPLGSSA---FMLHWKK--PLYPNGKLTGYKIYYEEVKESYVGERREYDPHITD-PR 976
            .|.:.|..|...|..   ..|:|..  ..:....:.||||.:.:..|.| |:......|..| |
Zfish   914 PPSRRLRVYKYVSFTRKWLYLYWDHIYNYWNESYVEGYKILFRKEGERY-GKLYTTGRHYIDFP- 976

  Fly   977 VTRMKMAGLKPNSKYRISITATTKMGEG 1004
                    :.....|.|.:.|..:.|:|
Zfish   977 --------MPETGDYVIELRARCEGGDG 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	23/79 (29%)
		IG_like	57..127	CDD:214653	23/76 (30%)
		Ig	135..214	CDD:299845	17/79 (22%)
		IG_like	141..216	CDD:214653	16/75 (21%)
		ig	251..332	CDD:278476	17/80 (21%)
		I-set	339..427	CDD:254352	23/99 (23%)
		Ig	354..427	CDD:299845	19/72 (26%)
		I-set	432..517	CDD:254352	32/87 (37%)
		Ig	446..517	CDD:299845	29/73 (40%)
		I-set	522..611	CDD:254352	28/93 (30%)
		ig	525..609	CDD:278476	26/88 (30%)
		FN3	613..707	CDD:238020	29/103 (28%)
		FN3	716..807	CDD:238020	20/102 (20%)
		fn3	817..905	CDD:278470	24/88 (27%)
		FN3	917..1004	CDD:238020	21/92 (23%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
cntn1b	NP_001014814.1	Ig	41..133	CDD:299845	27/99 (27%)
		I-set	42..135	CDD:254352	27/100 (27%)
		Ig	138..234	CDD:299845	25/109 (23%)
		IG_like	148..219	CDD:214653	17/80 (21%)
		Ig	245..332	CDD:299845	20/101 (20%)
		IG_like	253..331	CDD:214653	19/92 (21%)
		Ig	336..412	CDD:299845	22/86 (26%)
		IG_like	343..412	CDD:214653	20/79 (25%)
		IG_like	428..505	CDD:214653	29/76 (38%)
		Ig5_Contactin_like	434..505	CDD:143170	28/70 (40%)
		IG_like	515..604	CDD:214653	26/88 (30%)
		Ig	524..608	CDD:299845	22/83 (27%)
		FN3	608..708	CDD:238020	29/102 (28%)
		FN3	716..808	CDD:238020	22/104 (21%)
		fn3	817..903	CDD:278470	24/87 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10556
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910