DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and CNTN5

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001230199.1	Gene:	CNTN5 / 53942	HGNCID:	2175	Length:	1100	Species:	Homo sapiens

Alignment Length:	1040	Identity:	270/1040 - (25%)
Similarity:	440/1040 - (42%)	Gaps:	91/1040 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQA-YDNRMLRQPGRGTLVITI 100
            |.:::|......|:    ..:.||..|.|.|.|.|::||.:.|.:: |...::    .||.:|:.
Human   105 PDDIIFPTDSDEKK----VALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLI----DGTFIISN 161

  Fly   101 PKD-EDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSP 164
            |.: :|.|||||.|:|..|:..|....::.|.|..|.......:...||:..:|.|:.|...|..
Human   162 PSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEI 226

  Fly   165 TVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVL 229
            ..:|:..|.  .|..:.::.|......|||:.|.|...|..|   |.|...:...:...:.....
Human   227 IYSWVFNEF--PSFVAEDSRRFISQETGNLYISKVQTSDVGS---YICLVKNTVTNARVLSPPTP 286

  Fly   230 LDVKQMGVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRIT 294
            |.::..||   ..::.|..:........|.:|..:::.|...|.|:|...|.|....|....|:.
Human   287 LTLRNDGV---MGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLR 348

  Fly   295 QGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFE 359
            :..  ..|.|.....||||.|.|...|..|. .||...|.|.:.|::.::...........:.:|
Human   349 KSQ--AVLEIPNVQLDDAGIYECRAENSRGK-NSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWE 410

  Fly   360 CRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVY 424
            |:|.|.|.|...|:.||.|:   :|..|..:.:..:.|.|:.:.|.|.|.|.|.|..|.:|....
Human   411 CKATGKPRPTYRWLKNGVPL---SPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAE 472

  Fly   425 LNVQAEPPT--ISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLE 486
            |.:.|..||  :::....:.....:.|.|:|:..|||||.:.|.:....: ...|..:..:|.|.
Human   473 LKILASAPTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLR 537

  Fly   487 IQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLE 551
            |.:.:.||.|||.|..:|.||..:...||.|||.|||...|:..|:..|:|....|...||.:|:
Human   538 ILNASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLD 602

  Fly   552 IEIDWWKDGQSIDFEAQPRF-----VKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIV 611
            :...|...||.||||.:...     .:.:...|.|...:.:.:|.|.|..:|..|..:..|.|:|
Human   603 VTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLV 667

  Fly   612 QDVPNAPKLTGITCQAD----KAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP---- 668
            :..|..|   ||....:    .|.:.|....||.|||..|.:|..:.|: ..|... :.||
Human   668 RGPPGPP---GIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFS-LGWQTV-KTVPEIIT 727

  Fly   669 -NTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVI 732
             :.:|:..|.::||..|.|||:|.|.||...||..|....|...||...|.||.|:....:.|||
Human   728 GDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNVSGRSGRRHELVI 792

  Fly   733 SWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQ--PTFVKYLIKVVAIND 795
            :|.|:.|...|...|.|.|:: |......|:...:.....:..:..|:  |....:.:||...|:
Human   793 AWEPVSEEFQNGEGFGYIVAF-RPNGTRGWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNN 856

  Fly   796 RGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTEN 860
            :|:... ::.||..|.|..|..|||:.....::.|.. .:||..:.|.  .|..:|:::..|.:.
Human   857 KGDGPF-SQIVVICSAEGEPSAAPTDVKATSVSVSEI-LVAWKHIKES--LGRPQGFEVGYWKDM 917

  Fly   861 EGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDA 925
            |.|:....:..:|:....::|..:.::..:..:.||||...||||:.:...|.:..||.......
Human   918 EQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNLR 982

  Fly   926 YPLGSSAFMLHWKK--PLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKP- 987
            :....|...|.|:.  ||....::.|||::|.:            :.|.....:...|:..:.|
Human   983 WEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQ------------EGHSNSQVIETQKLQAVVPL 1035

  Fly   988 --NSKYRISITATTKMGEGSE---------------------HYIEKTTLKDAVNVAPATPSFSW 1029
              ...|.|.:.|.::.|:|:.                     |.:..::....:.:|...||.||
Human  1036 PDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSLSTSSSSVTLLLALMIPSTSW 1100

Fly 1030 1029
Human 1101 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	25/74 (34%)
		IG_like	57..127	CDD:214653	25/71 (35%)
		Ig	135..214	CDD:299845	20/78 (26%)
		IG_like	141..216	CDD:214653	19/74 (26%)
		ig	251..332	CDD:278476	22/80 (28%)
		I-set	339..427	CDD:254352	24/87 (28%)
		Ig	354..427	CDD:299845	23/72 (32%)
		I-set	432..517	CDD:254352	26/87 (30%)
		Ig	446..517	CDD:299845	24/71 (34%)
		I-set	522..611	CDD:254352	26/93 (28%)
		ig	525..609	CDD:278476	23/88 (26%)
		FN3	613..707	CDD:238020	32/102 (31%)
		FN3	716..807	CDD:238020	22/92 (24%)
		fn3	817..905	CDD:278470	20/87 (23%)
		FN3	917..1004	CDD:238020	18/91 (20%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
CNTN5	NP_001230199.1	Ig1_Contactin-5	98..191	CDD:143256	28/93 (30%)
		I-set	99..190	CDD:254352	28/92 (30%)
		Ig	193..287	CDD:299845	21/98 (21%)
		IG_like	205..278	CDD:214653	19/77 (25%)
		Ig	300..387	CDD:299845	24/89 (27%)
		I-set	300..386	CDD:254352	24/88 (27%)
		I-set	390..475	CDD:254352	24/87 (28%)
		Ig	392..475	CDD:299845	23/85 (27%)
		I-set	489..568	CDD:254352	24/78 (31%)
		Ig5_Contactin_like	496..568	CDD:143170	24/71 (34%)
		I-set	573..667	CDD:254352	26/93 (28%)
		Ig	587..671	CDD:299845	22/83 (27%)
		FN3	671..768	CDD:238020	32/101 (32%)
		FN3	776..868	CDD:238020	23/93 (25%)
		FN3	878..969	CDD:238020	22/93 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..982		7/22 (32%)
		FN3	977..1062	CDD:238020	17/96 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10657
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810