DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Cntn6

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_059079.2	Gene:	Cntn6 / 53870	MGIID:	1858223	Length:	1028	Species:	Mus musculus

Alignment Length:	1083	Identity:	314/1083 - (28%)
Similarity:	484/1083 - (44%)	Gaps:	128/1083 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQSTILAALLVALL-----CAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECE 60
            :|:        ||.||     |||  |.:.:||..|.:   |.:::|.:.....|    .|:.|.
Mouse     4 LWK--------LVILLPLINSCAG--EGRFSRPIFIQE---PQDVIFPLDLSRSE----IILTCT 51

  Fly    61 ADGQPEPEYSWIKNGKKFDW-QAYDNRMLRQPGRGTLVITIPK-DEDRGHYQCFASNEFGTATSN 123
            |:|.|.|.|.|.:||...|: ..|..|:    ..|:|.|:.|: |:|.|.|||.|:|..||..|.
Mouse    52 ANGYPSPHYRWKQNGTDIDFGMTYHYRL----DGGSLAISSPRTDQDIGIYQCLATNPVGTILSR 112

  Fly   124 SVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNW-------MIQESIDGSIKSI 181
            ...::.|.:..|:.:...|:...||:..:|.|..|..|...:..|       .:||
Mouse   113 KAKLQFAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGELSYAWTFNDSPLYVQE--------- 168

  Fly   182 NNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPP 246
            :..|......|||:|:.|...|..:   |.|..|:........|....|.::..||.........
Mouse   169 DKRRFVSQDTGNLYFAKVEPSDVGN---YTCFVTNKEAHRSVQGPPTPLVLRTDGVMGEYEPKIE 230

  Fly   247 VRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKS---LVIRQTN 308
            || :....|  |.:...::|.|...|.|:|...|    :|:..|....:..|.||   |.|.:..
Mouse   231 VR-FPETIQ--AAKDSSIKLECFALGNPVPDISW----KRLDGSPMPGKIKYSKSQAILEIPKFQ 288

  Fly   309 FDDAGTYTCDVSNGVG-NAQSFSIILNVNSVPYFTKEPEIATAAED------EEVVFECRAAGVP 366
            .:|.|.|.|...|..| |.....:|        |...||.....::      :.:.:||:|:|.|
Mouse   289 QEDEGFYECIAGNLRGRNLAKGQLI--------FYAPPEWEQKIQNTYLSIYDSLFWECKASGNP 345

  Fly   367 EPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEP 431
            .|..:|:.||   ::.....|..:.:.|:.|..|...|:|.|.|.|.|....:|.:..|.|.|..
Mouse   346 NPSYTWLKNG---QRLNTEERIQIENGTLIITMLNISDSGIYQCAAENKYQTIYANAELRVLASA 407

  Fly   432 PTISEAP-AAVSTVD-GRNVTIKCRVNGSPKPLVKWLRAS-NWLTGGRYNVQANGDLEIQDVTFS 493
            |..|:.| ..:|.|. |.:::|:|:.|..||..:.|.|.: |.....|.....:|.|:|.:||.:
Mouse   408 PDFSKNPIKKISVVQVGGDISIECKPNAFPKASISWKRGTENLKQSKRVLFLEDGSLKICNVTRA 472

  Fly   494 DAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWK 558
            |||.|||.|.|:||..::.|.|||||.|.||..|...:|..|:|....|..:||.|:|:...|:.
Mouse   473 DAGSYTCVATNQFGNGKSSGGLVVKERTIITVPPSKMDVTVGESIVLPCQVSHDPTMEVLFVWYF 537

  Fly   559 DGQSIDF-EAQPRFVKTNDNSL--TIAKTMEL-DSGEYTCVARTRLDEATARANLIVQDVPNAP- 618
            :|..||. :....|.:....|:  .:.:.::| .||:|.|..:|.|:..:|.|::||:..|..|
Mouse   538 NGDIIDLKKGVAHFERIGGESVGDLMIRNIQLGHSGKYLCTVQTTLERLSAVADIIVRGPPGPPE 602

  Fly   619 --KLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP-----NTDSSFVV 676
              |:..|:  :..:::.|....||.|||..:|||..|.|: ..|.|. ..||     .|.::.||
Mouse   603 DVKVEHIS--STTSQLSWRPGPDNNSPIQIFTIQTRTPFS-VGWQAV-ATVPEILNGQTYNATVV 663

  Fly   677 QMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIE 741
            .:|||..|.|||:|.|.||...||..|:...|:..||...|.|:.|.|...:.|||:|..:||..
Mouse   664 GLSPWVEYEFRVVAGNNIGIGEPSKPSELLRTKASVPNVAPGNINGGGGSRSELVITWEAIPEEL 728

  Fly   742 HNAPNFHYYVSWKRDIPAAAWENNNI-------FDWRQNNIVIADQPTFVKYLIKVVAINDRGES 799
            .|...|.|.|.: |.:...||....:       |.:|..:|:     ....:.:||...|:.||.
Mouse   729 QNGEGFGYIVMF-RPVGTTAWMKERVALVESSKFIYRNESIM-----PLSPFEVKVGVYNNEGEG 787

  Fly   800 NVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEE 864
            :::...:| |||||.|..||.. |..|..|::...::|..::.....|...||::..||:|..|.
Mouse   788 SLSTVTIV-YSGEDEPQLAPRG-TSVQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDNSKES 850

  Fly   865 GLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLG 929
            .:.:|.|.|:.....:|..:.::..:|.:.|||....||.|..::..|.:..||......|:.|.
Mouse   851 MIGKIRVSGNVTTKNITGLRANTIYFASVRAYNTAGTGPSSLPVNVTTKKSPPSQPPANIAWKLS 915

  Fly   930 SSAFMLHWK--KPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKP-NSKY 991
            :|...|:|:  |.:....::.||||.|.        :.|:...||.:...|..::  |.| ...|
Mouse   916 NSKLCLNWEHVKTMENESEVLGYKILYR--------QNRQSKTHILETNNTSAEL--LVPFEEDY 970

  Fly   992 RISITATTKMGEGS---EHYIEKTTLKDAVNV---APATPSFS 1028
            .|.|...:..|:||   |..|.|.:...:..|   .|:|.|.|
Mouse   971 LIEIRTVSDGGDGSSSEEIRIPKMSSLSSTGVQISKPSTQSLS 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	28/74 (38%)
		IG_like	57..127	CDD:214653	27/71 (38%)
		Ig	135..214	CDD:299845	20/85 (24%)
		IG_like	141..216	CDD:214653	19/81 (23%)
		ig	251..332	CDD:278476	22/84 (26%)
		I-set	339..427	CDD:254352	24/93 (26%)
		Ig	354..427	CDD:299845	21/72 (29%)
		I-set	432..517	CDD:254352	32/87 (37%)
		Ig	446..517	CDD:299845	27/71 (38%)
		I-set	522..611	CDD:254352	26/92 (28%)
		ig	525..609	CDD:278476	24/87 (28%)
		FN3	613..707	CDD:238020	36/101 (36%)
		FN3	716..807	CDD:238020	25/97 (26%)
		fn3	817..905	CDD:278470	23/87 (26%)
		FN3	917..1004	CDD:238020	23/89 (26%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Cntn6	NP_059079.2	Ig	26..120	CDD:416386	33/104 (32%)
		Ig strand A	27..31	CDD:409353	1/3 (33%)
		Ig strand A'	34..39	CDD:409353	1/4 (25%)
		Ig strand B	45..53	CDD:409353	3/11 (27%)
		Ig strand C	58..64	CDD:409353	3/5 (60%)
		Ig strand C'	66..69	CDD:409353	1/2 (50%)
		Ig strand D	76..80	CDD:409353	1/7 (14%)
		Ig strand E	82..88	CDD:409353	3/5 (60%)
		Ig strand F	95..104	CDD:409353	5/8 (63%)
		Ig strand G	107..120	CDD:409353	3/12 (25%)
		Ig	129..214	CDD:416386	21/96 (22%)
		Ig strand A	130..135	CDD:409353	1/4 (25%)
		Ig strand B	139..145	CDD:409353	1/5 (20%)
		Ig strand C	153..159	CDD:409353	1/5 (20%)
		Ig strand C'	164..166	CDD:409353	0/1 (0%)
		Ig strand D	171..176	CDD:409353	1/4 (25%)
		Ig strand E	179..183	CDD:409353	3/3 (100%)
		Ig strand F	193..201	CDD:409353	3/10 (30%)
		Ig strand G	203..214	CDD:409353	1/10 (10%)
		Ig	227..315	CDD:416386	25/102 (25%)
		Ig strand A	227..232	CDD:409353	0/4 (0%)
		Ig strand A'	235..240	CDD:409353	1/6 (17%)
		Ig strand B	243..252	CDD:409353	2/8 (25%)
		Ig strand C	258..262	CDD:409353	1/7 (14%)
		Ig strand C'	265..267	CDD:409353	0/1 (0%)
		Ig strand D	276..279	CDD:409353	1/2 (50%)
		Ig strand E	280..285	CDD:409353	1/4 (25%)
		Ig strand F	293..301	CDD:409353	3/7 (43%)
		Ig strand G	304..315	CDD:409353	3/18 (17%)
		Ig	319..403	CDD:416386	22/86 (26%)
		Ig strand A	319..322	CDD:409353	1/2 (50%)
		Ig strand A'	326..330	CDD:409353	0/3 (0%)
		Ig strand B	334..342	CDD:409353	2/7 (29%)
		Ig strand C	348..353	CDD:409353	1/4 (25%)
		Ig strand C'	355..358	CDD:409353	1/5 (20%)
		Ig strand D	363..367	CDD:409353	1/3 (33%)
		Ig strand E	369..374	CDD:409353	1/4 (25%)
		Ig strand F	383..390	CDD:409353	3/6 (50%)
		Ig strand G	394..403	CDD:409353	2/8 (25%)
		Ig5_Contactin	408..496	CDD:409358	32/87 (37%)
		Ig strand B	427..431	CDD:409358	1/3 (33%)
		Ig strand C	440..444	CDD:409358	0/3 (0%)
		Ig strand E	462..466	CDD:409358	2/3 (67%)
		Ig strand F	476..481	CDD:409358	3/4 (75%)
		Ig strand G	489..492	CDD:409358	0/2 (0%)
		Ig	500..598	CDD:416386	29/97 (30%)
		Ig strand A'	507..512	CDD:409353	0/4 (0%)
		Ig strand B	515..523	CDD:409353	2/7 (29%)
		Ig strand C	532..536	CDD:409353	0/3 (0%)
		Ig strand E	560..564	CDD:409353	0/3 (0%)
		Ig strand F	573..580	CDD:409353	3/6 (50%)
		Ig strand G	587..591	CDD:409353	1/3 (33%)
		FN3	598..691	CDD:238020	35/96 (36%)
		FN3	703..796	CDD:238020	26/99 (26%)
		FN3	805..898	CDD:238020	24/93 (26%)
		FN3	903..983	CDD:214495	23/89 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810