DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and NCAM2

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	821	Identity:	194/821 - (23%)
Similarity:	301/821 - (36%)	Gaps:	186/821 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTA 120
            ::..::.||...:|. .:.|...||: |:..:..:.|:       |:
Human     1 MVRSDSGGQVYLDYH-NRQGLFVDWK-YNEALYLEEGQ-------PE------------------ 38

  Fly   121 TSNSVYVRKAELNAFKDEAAKTLEAVE---GEPFMLKCAAPDGFPSPTVNWMIQESID-----GS 177
                .|.|.|.|     :...:|..||   ||.....|.| .|.|         ||||     |.
Human    39 ----TYYRTALL-----QVTISLSKVELSVGESKFFTCTA-IGEP---------ESIDWYNPQGE 84

  Fly   178 IKSINNSRMTLDPEG---NLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSA 239
             |.|:..|:.:..||   .|...|...|||.   .|.|.||.......:.  .|:|::.|
Human    85 -KIISTQRVVVQKEGVRSRLTIYNANIEDAG---IYRCQATDAKGQTQEA--TVVLEIYQ----- 138

  Fly   240 SQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHY----GK 300
                ....|:.||.::  ..:|:..|:.|....:|.|...|....:.:   ..|:...:    ..
Human   139 ----KLTFREVVSPQE--FKQGEDAEVVCRVSSSPAPAVSWLYHNEEV---TTISDNRFAMLANN 194

  Fly   301 SLVIRQTNFDDAGTYTCD---VSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRA 362
            :|.|...|..|.|.|.|:   .:.|..:.:...:|:||.......::...|||...||:.|.|||
Human   195 NLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAISMPQKSFNATAERGEEMTFSCRA 259

  Fly   363 AGVPEPKISWIHNGKPIEQSTPNPRRTV----TDNTIRIINLVKGDTGNYGCNATNSLGYVYKDV 423
            :|.|||.|||..|||.||:   |.:..:    |:.|:|  |::..|.|.|.|.|||..|...|..
Human   260 SGSPEPAISWFRNGKLIEE---NEKYILKGSNTELTVR--NIINSDGGPYVCRATNKAGEDEKQA 319

  Fly   424 YLNVQAEPPTI---SEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLT--------GGRY 477
            :|.|..:|..|   :|     :|.:...||:.|...|.|.|.:.|.||.:..|        .||.
Human   320 FLQVFVQPHIIQLKNE-----TTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRI 379

  Fly   478 NVQ---ANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSAT 539
            .|:   .:..|.|:||..||:|:|.|.|.::.|..|....|.::...:.......|....|....
Human   380 EVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFISNQTIYYSWEGNPIN 444

  Fly   540 FRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNS----LTIAKTMELDSGEYTCVARTRL 600
            ..|:...:....|.   |:..:.:........:||....    |.||.|.:.|.|.|.|.|...:
Human   445 ISCDVKSNPPASIH---WRRDKLVLPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHI 506

  Fly   601 DEATARANLIVQDVPNAP------KLTGITCQA--DKAEIHWEQQGDNRSPILHYTIQFNTSFTP 657
            ........|.:.|||::|      :|:..|.:.  :|.:.|      ...||.||.:...
Human   507 GTRFQEYILALADVPSSPYGVKIIELSQTTAKVSFNKPDSH------GGVPIHHYQVDVK----- 560

  Fly   658 ASWDAAYE--KVPNTD--SSFVV--QMSPWANYTFRVIAFNKIG-----------------ASPP 699
               :.|.|  |:..:.  .:.||  .:.|...|..||.|.|..|                 .|||
Human   561 ---EVASEIWKIVRSHGVQTMVVLNNLEPNTTYEIRVAAVNGKGQGDYSKIEIFQTLPVREPSPP 622

  Fly   700 SAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWEN 764
            |.|                   ||.:...:..:|.|  .:.:..||...|.|.::.......|..
Human   623 SIH-------------------GQPSSGKSFKLSIT--KQDDGGAPILEYIVKYRSKDKEDQWLE 666

  Fly   765 NNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEE 805
            ..: ...:::|::......:.|.:::.|.|..|.|.....|
Human   667 KKV-QGNKDHIILEHLQWTMGYEVQITAANRLGYSEPTVYE 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	10/71 (14%)
		IG_like	57..127	CDD:214653	9/69 (13%)
		Ig	135..214	CDD:299845	26/89 (29%)
		IG_like	141..216	CDD:214653	27/85 (32%)
		ig	251..332	CDD:278476	17/87 (20%)
		I-set	339..427	CDD:254352	36/91 (40%)
		Ig	354..427	CDD:299845	33/76 (43%)
		I-set	432..517	CDD:254352	29/98 (30%)
		Ig	446..517	CDD:299845	26/81 (32%)
		I-set	522..611	CDD:254352	17/92 (18%)
		ig	525..609	CDD:278476	16/87 (18%)
		FN3	613..707	CDD:238020	29/124 (23%)
		FN3	716..807	CDD:238020	16/90 (18%)
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274	31/111 (28%)
		I-set	47..136	CDD:254352	30/104 (29%)
		I-set	142..218	CDD:254352	17/80 (21%)
		IGc2	153..214	CDD:197706	14/63 (22%)
		Ig	233..326	CDD:299845	37/97 (38%)
		I-set	240..323	CDD:254352	36/87 (41%)
		Ig5_NCAM-2	325..422	CDD:143278	30/101 (30%)
		IG_like	333..420	CDD:214653	27/91 (30%)
		IG_like	438..515	CDD:214653	15/79 (19%)
		IGc2	439..507	CDD:197706	15/70 (21%)
		FN3	521..613	CDD:238020	22/105 (21%)
		fn3	619..703	CDD:278470	20/105 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I10004
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910