DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and NCAM1

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	807	Identity:	183/807 - (22%)
Similarity:	296/807 - (36%)	Gaps:	205/807 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQ-PEPEYSWIK- 73
            |:..|...|:|.|.     ::...|:.||:        ...::.|.: |:..|. .:.:.||..
Human     7 LIWTLFFLGTAVSL-----QVDIVPSQGEI--------SVGESKFFL-CQVAGDAKDKDISWFSP 57

  Fly    74 NGKKFD---------WQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRK 129
            ||:|..         |        ......||.|.....:|.|.|:|..:.|.|:.:..:|.|:.
Human    58 NGEKLTPNQQRISVVW--------NDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKI 114

  Fly   130 AELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNL 194
            .:...||: |....|..|||..::.|......| ||:.|. .:..|..:|  .:.|..:.....|
Human   115 FQKLMFKN-APTPQEFREGEDAVIVCDVVSSLP-PTIIWK-HKGRDVILK--KDVRFIVLSNNYL 174

  Fly   195 WFSNVTREDASSDFYYACSATSVFRSEYKIGN-KVLLDVKQMGVSASQNKHPPVRQYVSRRQSL- 257
            ....:.:.|..:   |.|....:.|.|....: :|:::|            ||.   :..||::
Human   175 QIRGIKKTDEGT---YRCEGRILARGEINFKDIQVIVNV------------PPT---IQARQNIV 221

  Fly   258 ---ALRGKRMELFCIYGGTPLPQTVWSKDGQRIQ---------WSDRITQGHYGKSLVIRQTNFD 310
               |..|:.:.|.|...|.|.|...|:|||::|:         :||..:|      |.|::.:.:
Human   222 NATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQ------LTIKKVDKN 280

  Fly   311 DAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAE-DEEVVFECRAAGVPEPKISW-- 372
            |...|.|...|..|. |..:|.|.|.:.|..| ..|..||.| :|:|...|.|:|.|.|.|:|
Human   281 DEAEYICIAENKAGE-QDATIHLKVFAKPKIT-YVENQTAMELEEQVTLTCEASGDPIPSITWRT 343

  Fly   373 --------------------IH----------NGKPIEQSTPNPRRT------------VTDNTI 395
                                :|          .|:......|....|            |:..|:
Human   344 STRNISSEEKASWTRPEKQEVHAPWNWQVGRQKGQAGSAGFPGSHETLDGHMVVRSHARVSSLTL 408

  Fly   396 RIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPK 460
            :.|...  |.|.|.|.|:|::|...:.:||.||..|..  :.|.||.|.:|..|.|.|.|...|.
Human   409 KSIQYT--DAGEYICTASNTIGQDSQSMYLEVQYAPKL--QGPVAVYTWEGNQVNITCEVFAYPS 469

  Fly   461 PLVKWLR------ASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGE-------IQAD 512
            ..:.|.|      :||:.....||..:...||:...:.:|.|.|.|.|.|:.|:       :|||
Human   470 ATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQAD 534

  Fly   513 GSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEID---------------------- 555
                      ....|...:|           |.:..|.:::.|
Human   535 ----------TPSSPSIDQV-----------EPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGE 578

  Fly   556 --W---WKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDS---GEYTCVARTRLDEATARANLIVQ 612
              |   |.|.:....|.....|.....:....:...|:.   ||.:..:..:...        ||
Human   579 EVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQP--------VQ 635

  Fly   613 DVPNAPKLTG-ITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVV 676
            ..|:||||.| :....:..:::..:|.|..|||.||.:::..  ..:.|.... ::|:.....::
Human   636 GEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRA--LSSEWKPEI-RLPSGSDHVML 697

  Fly   677 QMSPW-ANYTFRVIAFNKIGASPPSAH 702
            :...| |.|...|:|.|:.|.| .:||
Human   698 KSLDWNAEYEVYVVAENQQGKS-KAAH 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	19/83 (23%)
		IG_like	57..127	CDD:214653	18/80 (23%)
		Ig	135..214	CDD:299845	19/78 (24%)
		IG_like	141..216	CDD:214653	16/74 (22%)
		ig	251..332	CDD:278476	25/93 (27%)
		I-set	339..427	CDD:254352	31/132 (23%)
		Ig	354..427	CDD:299845	25/116 (22%)
		I-set	432..517	CDD:254352	28/97 (29%)
		Ig	446..517	CDD:299845	24/83 (29%)
		I-set	522..611	CDD:254352	13/118 (11%)
		ig	525..609	CDD:278476	13/113 (12%)
		FN3	613..707	CDD:238020	25/92 (27%)
		FN3	716..807	CDD:238020
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	23/116 (20%)
		IG	124..190	CDD:214652	15/72 (21%)
		Ig	211..307	CDD:325142	30/105 (29%)
		Ig	306..438	CDD:325142	31/134 (23%)
		Ig_3	447..519	CDD:316449	23/71 (32%)
		FN3	534..631	CDD:238020	14/117 (12%)
		fn3	639..720	CDD:306538	22/84 (26%)
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910