DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrg and LIFR

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:XP_016864951.1 Gene:LIFR / 3977 HGNCID:6597 Length:1115 Species:Homo sapiens


Alignment Length:1195 Identity:210/1195 - (17%)
Similarity:360/1195 - (30%) Gaps:451/1195 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 GSAESKGNRPPRITKQPAPGELLFKVAQQNKE--SDNPFIIECEADGQPEPEY-SWIKNGKKFDW 80
            ||:.||                 |.:.:||..  .|.|.|:...||......| .|...|..|..
Human   137 GSSTSK-----------------FTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPH 184

  Fly    81 QA---YDNRMLRQPGRGTLVI----TIPKDEDRGHYQCFASNEFGTATSNSV----YVRKAELNA 134
            ::   ::.::||:.....:.:    |....:|..|:..:||:.......:.|    |:.....:.
Human   185 RSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSG 249

  Fly   135 FKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNLWFSNV 199
            .::.:                   |..|...::|            |.:|:..:.|:..:..   
Human   250 LEEWS-------------------DWSPVKNISW------------IPDSQTKVFPQDKVIL--- 280

  Fly   200 TREDASSDFYYACSATSVFRSEYKI----------------GNKVLLDVKQMGVSASQNK----- 243
                ..||..:.|.      |:.|:                |..|.:.::.:.||||...     
Human   281 ----VGSDITFCCV------SQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFT 335

  Fly   244 -------------HPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQ 295
                         :||........::..|:    |:.|.:.    |..|.:..|.|.. |..:.:
Human   336 TEDNIFGTVIFAGYPPDTPQQLNCETHDLK----EIICSWN----PGRVTALVGPRAT-SYTLVE 391

  Fly   296 GHYGK---------------SLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEP 345
            ...||               .|:.:.....:...:|.:..|.:|.:|| :|::|:....|    |
Human   392 SFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQS-TILVNITEKVY----P 451

  Fly   346 EIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGC 410
            ...|:       |:.:.......|:||...|                |..:|         |:.|
Human   452 HTPTS-------FKVKDINSTAVKLSWHLPG----------------NFAKI---------NFLC 484

  Fly   411 NATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGG 475
            ..                       |...:.|..:.||||||...|            |::|   
Human   485 EI-----------------------EIKKSNSVQEQRNVTIKGVEN------------SSYL--- 511

  Fly   476 RYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATF 540
                          |.......||.|                                     ||
Human   512 --------------VALDKLNPYTLY-------------------------------------TF 525

  Fly   541 --RCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEA 603
              ||:   .:|......|....|.:..||.|.  |..|                     |..:.:
Human   526 RIRCS---TETFWKWSKWSNKKQHLTTEASPS--KGPD---------------------TWREWS 564

  Fly   604 TARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRS--PILHYTIQFNTSFTPASWDAAYEK 666
            :...|||                     |:|:....|.:  .||.|    |.|.:......:..:
Human   565 SDGKNLI---------------------IYWKPLPINEANGKILSY----NVSCSSDEETQSLSE 604

  Fly   667 VPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLV 731
            :|:......:::.. .:|...|:|.|.:|:||||..:.......|:..   :.|||.|   ..::
Human   605 IPDPQHKAEIRLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKI---EQVVGMG---KGIL 662

  Fly   732 ISWTPMPEIEHNAPNF--HYYVSW---KRDIPAAAWENNNIFDWRQ------NNIVIADQPTF-- 783
            ::|       |..||.  .|.:.|   .|..|.       :.|||:      ..::.:|:  |  
Human   663 LTW-------HYDPNMTCDYVIKWCNSSRSEPC-------LMDWRKVPSNSTETVIESDE--FRP 711

  Fly   784 -VKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRG 847
             ::|...:....::|..  ....::||..|..|:.|| |||:.. ||:.|..:.|..:..|.:||
Human   712 GIRYNFFLYGCRNQGYQ--LLRSMIGYIEELAPIVAP-NFTVED-TSADSILVKWEDIPVEELRG 772

  Fly   848 HFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDT 912
            ..:||   .:...:||.         ||....|.:              :||.:.....:.|...
Human   773 FLRGY---LFYFGKGER---------DTSKMRVLE--------------SGRSDIKVKNITDISQ 811

  Fly   913 PEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVG-------------- 963
            .....:.:||..:|.|...|         |.:|.:...|..|...||:.||              
Human   812 KTLRIADLQGKTSYHLVLRA---------YTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVI 867

  Fly   964 ----------ERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAV 1018
                      .:||:......|.:         ||.:...::.....:.|||      :.|| .:
Human   868 VGVVTSILCYRKREWIKETFYPDI---------PNPENCKALQFQKSVCEGS------SALK-TL 916

  Fly  1019 NVAPATPSFSWEQLPSDNGLAKFRINWLPS---------TEGHPGTHFFTMHRIKGETQWIRENE 1074
            .:.|.||: :.|.|.:.:...|.....:.|         ::..|..|....:     ...|.|.|
Human   917 EMNPCTPN-NVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSY-----CPPIIEEE 975

  Fly  1075 EKNSDYQEVGG------LDPETAYE 1093
            ..|....|.||      :|.::.|:
Human   976 IPNPAADEAGGTAQVIYIDVQSMYQ 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 16/84 (19%)
IG_like 57..127 CDD:214653 14/81 (17%)
Ig 135..214 CDD:299845 9/78 (12%)
IG_like 141..216 CDD:214653 9/74 (12%)
ig 251..332 CDD:278476 16/95 (17%)
I-set 339..427 CDD:254352 12/87 (14%)
Ig 354..427 CDD:299845 9/72 (13%)
I-set 432..517 CDD:254352 15/84 (18%)
Ig 446..517 CDD:299845 13/70 (19%)
I-set 522..611 CDD:254352 15/90 (17%)
ig 525..609 CDD:278476 13/85 (15%)
FN3 613..707 CDD:238020 18/95 (19%)
FN3 716..807 CDD:238020 19/104 (18%)
fn3 817..905 CDD:278470 21/87 (24%)
FN3 917..1004 CDD:238020 18/110 (16%)
FN3 1041..1111 CDD:238020 12/68 (18%)
Bravo_FIGEY 1155..>1221 CDD:290593
LIFRXP_016864951.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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