DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and IL6ST

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_002175.2	Gene:	IL6ST / 3572	HGNCID:	6021	Length:	918	Species:	Homo sapiens

Alignment Length:	831	Identity:	170/831 - (20%)
Similarity:	283/831 - (34%)	Gaps:	222/831 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 FEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTR-----LDEATARANL---------IVQDVP 615
            |.....::....|..||.|.      :||.:.||.     .|.|:....|         :.|:|.
Human    58 FHVNANYIVWKTNHFTIPKE------QYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVY 116

  Fly   616 NAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVVQMSP 680
            ....::|:..:..|          |.|.|::...:..     ..||...|  .:.:::|.:: |.
Human   117 GITIISGLPPEKPK----------NLSCIVNEGKKMR-----CEWDGGRE--THLETNFTLK-SE 163

  Fly   681 WANYTFRVIAFNKIGASPPSAHSDSCTTQ-PDVPFKN------PDNVVGQGTEPNNLVISWTPMP 738
            ||.:.|   |..|.....|:    |||.. ..|.|.|      .:|.:|:.|..:   |::.|:.
Human   164 WATHKF---ADCKAKRDTPT----SCTVDYSTVYFVNIEVWVEAENALGKVTSDH---INFDPVY 218

  Fly   739 EIEHNAPNFHYYVSWKR--DIPAAAWENNNI-----------------FDWRQ----------NN 774
            :::.|.|:....::.:.  .|....|.|.:|                 ..|.|          ::
Human   219 KVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSS 283

  Fly   775 IVIADQPTFVKYLIKVVAINDRGESNVA--AEEVVGYSGEDRPLDAPTNFTMRQITSSTSGY--- 834
            ..:.|...|.:|:.::..:.:.|:...:  :||..|.:.||||..|| :|..:...|.|.||
Human   284 FTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAP-SFWYKIDPSHTQGYRTV 347

  Fly   835 -MAWTPVSEESVRGHFKGYKI--QTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAY 896
             :.|..:......|....|::  ..|          :.|::..|.||........:..|...|..
Human   348 QLVWKTLPPFEANGKILDYEVTLTRW----------KSHLQNYTVNATKLTVNLTNDRYLATLTV 402

  Fly   897 NGRFNGPPSAVI-----DFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEE 956
            ........:||:     ||....    ||..|.|:| ..:...:.|..|             .|.
Human   403 RNLVGKSDAAVLTIPACDFQATH----PVMDLKAFP-KDNMLWVEWTTP-------------RES 449

  Fly   957 VKESYVGE---RREYDPHIT-----DPRVTRMKMAGLKPNSK-YRISITATTKMGEGSEHYIEKT 1012
            ||: |:.|   ..:..|.||     |..|.|..:.|....|| |.|::|.....|.||...| |.
Human   450 VKK-YILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESI-KA 512

  Fly  1013 TLKDA----------VNVAPATPSFSWEQLPSD--NGLAKFRINWLPSTEGHPGTHFFTMHR--I 1063
            .||.|          ..|........|:|||.|  ||..:               ::...:|  |
Human   513 YLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIR---------------NYTIFYRTII 562

  Fly  1064 KGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETV 1128
            ..||   ..|.:.:.....:..|..:|.|..|:.:.     |:...::....|...|.....|..
Human   563 GNET---AVNVDSSHTEYTLSSLTSDTLYMVRMAAY-----TDEGGKDGPEFTFTTPKFAQGEIE 619

  Fly  1129 ANAGWFIGMMLALAFII--ILFIIICIIRRNRGGKY---DVHD---------------RELANGR 1173
            |     |.:.:.|||::  :|.::.|..:|:...|:   :|.|               |...|.:
Human   620 A-----IVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSK 679

  Fly  1174 RDYPEEGGFHEYSQ-----------PLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTAVATA 1227
            .....:|.|.:.|.           |.|.||.........|..|..|        |.|.::..::
Human   680 DQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSS--------GIGGSSCMSS 736

  Fly  1228 AARAAAAARSKLTSLPTSTQQQQQQQQQQQQQQEQPQ----STSASTVPLI 1274
            :..:.:::....:|..||:..|.........:.:.|.    |.|.||.||:
Human   737 SRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLL 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476
		I-set	339..427	CDD:254352
		Ig	354..427	CDD:299845
		I-set	432..517	CDD:254352
		Ig	446..517	CDD:299845
		I-set	522..611	CDD:254352	12/59 (20%)
		ig	525..609	CDD:278476	11/48 (23%)
		FN3	613..707	CDD:238020	18/93 (19%)
		FN3	716..807	CDD:238020	20/127 (16%)
		fn3	817..905	CDD:278470	17/93 (18%)
		FN3	917..1004	CDD:238020	25/95 (26%)
		FN3	1041..1111	CDD:238020	10/71 (14%)
		Bravo_FIGEY	1155..>1221	CDD:290593	17/94 (18%)
IL6ST	NP_002175.2	Lep_receptor_Ig	26..112	CDD:283889	12/59 (20%)
		FN3	121..215	CDD:304408	26/121 (21%)
		FN3	222..321	CDD:238020	15/98 (15%)
		WSXWS motif	310..314		0/3 (0%)
		FN3	519..599	CDD:214495	18/102 (18%)
		Box 1 motif	651..659		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..681		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..758		7/43 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000