DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrg and fipi

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_787975.1	Gene:	fipi / 33676	FlyBaseID:	FBgn0031627	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	345	Identity:	81/345 - (23%)
Similarity:	138/345 - (40%)	Gaps:	82/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 VSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSD---RITQGHY 298
            :|.|..:|..|| |.:  :||.::.:          :|.|:.       .:.|..   .|.:.|.
  Fly    25 LSLSPAEHSVVR-YTN--ESLIVQCR----------SPDPKV-------ELHWKSPKGEIIREHK 69

  Fly   299 GKSLVIRQTNFD------------DAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAA 351
            |: :.|.||:.:            |.|.::|:.::|..:::||.:|  |.....||:...:.|..
  Fly    70 GR-IHIEQTSTEQLKIVFAHIALADKGNWSCEAADGSLHSKSFDLI--VYQKITFTENATVMTVK 131

  Fly   352 EDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRII-------NLVKGDTGNYG 409
            |.|:....|...|.|:|.::|..||:||.....:      |:..||:       .:.:.|||.|.
  Fly   132 EGEKATILCEVKGEPQPNVTWHFNGQPISAGAAD------DSKFRILADGLLINKVTQNDTGEYA 190

  Fly   410 CNA--TNSLGYVYKD--VYLNVQAEP-----PTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKW 465
            |.|  .||:....::  |.:.::.:|     |.:|...|.::    ...|:.|.....|.....|
  Fly   191 CRAYQVNSIASDMQERTVLMKIEHKPIWSKTPFVSLKYAYIN----GTATLMCEALAEPPANFTW 251

  Fly   466 LRASNWLTGGR--YNVQAN---GDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQ 525
            .|..|.|....  |.:|::   ..|.|..:..|....|.|.|:|..|.|:        ..||:.|
  Fly   252 YRKHNKLHSNNRLYTIQSDSYWSSLTIHVLNTSAFDNYRCRARNDLGTIE--------RTTRLEQ 308

  Fly   526 -----EPQNYEVAAGQSATF 540
                 .|.|:::....|.||
  Fly   309 GEKPPSPANFQLRGFNSNTF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	17/95 (18%)
		I-set	339..427	CDD:254352	26/98 (27%)
		Ig	354..427	CDD:299845	22/83 (27%)
		I-set	432..517	CDD:254352	21/89 (24%)
		Ig	446..517	CDD:299845	18/75 (24%)
		I-set	522..611	CDD:254352	7/24 (29%)
		ig	525..609	CDD:278476	6/21 (29%)
		FN3	613..707	CDD:238020
		FN3	716..807	CDD:238020
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
fipi	NP_787975.1	IG_like	33..115	CDD:214653	21/104 (20%)
		I-set	128..202	CDD:254352	23/79 (29%)
		Ig	133..>193	CDD:299845	18/65 (28%)
		IG_like	228..307	CDD:214653	21/90 (23%)
		Ig	235..305	CDD:143165	18/77 (23%)
		FN3	312..415	CDD:238020	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100