DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Tnn

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_808507.2	Gene:	Tnn / 329278	MGIID:	2665790	Length:	1560	Species:	Mus musculus

Alignment Length:	1360	Identity:	250/1360 - (18%)
Similarity:	428/1360 - (31%)	Gaps:	408/1360 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 NKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQ---PGRGTLVITIPKDEDRGHY 109
            |:|::....:|.|   .|..|..:.|              ||.   .|:....:|:||..|....
Mouse   360 NEETETSLDVEWE---NPLTEVDYYK--------------LRYGPLTGQEVTEVTVPKSRDPKSR 407

  Fly   110 QCFASNEFGTATSNSVYVRKAEL-----------------NAFKDEAAKTLEAVEGEP------- 150
            ......:.||....:|...:.:|                 |...::..:...:|..:|
Mouse   408 YDITGLQPGTEYKITVVPIRGDLEGKPILLNGRTEIDGPTNVVTNQVTEDTASVSWDPVRADIDK 472

  Fly   151 FMLKCAAPDG------FP---SPTV-------------NWMIQESIDGSIKSINNSRMTLDPEGN 193
            ::::..||||      .|   |.||             .| .:....||.|:...:...:|...|
Mouse   473 YVVRYIAPDGETKEKAVPKDQSSTVLTGLKPGEAYKVFVW-AERGNQGSKKADTKALTEIDSPEN 536

  Fly   194 LWFSNVTREDASSDF--------YYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQY 250
            |....||....|..:        .|..|.|||                     ..:.|..||::
Mouse   537 LVTDRVTENSLSVSWDPVEADIDRYVVSYTSV---------------------DGETKQVPVKK- 579

  Fly   251 VSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQ-----------------WSDRITQGHY 298
              .::|..|.|       :..|......||::.|.|..                 .:|::|:...
Mouse   580 --DQRSTVLTG-------LSPGVEYKVYVWAEKGDRESKKANTKAPTDIDSPKNLVTDQVTENTL 635

  Fly   299 GKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAA 363
            ..|....|.|.|   .|....::..|..:                  |:....|....|......
Mouse   636 SVSWDPVQANID---RYMVSYTSADGETR------------------EVPVPKEKSSTVLTGLRP 679

  Fly   364 GVPEPKISWIHNG----KPIEQSTP----NPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVY 420
            ||......|...|    :......|    .|:..|||........|..|.             |.
Mouse   680 GVEYKVHVWAQKGTQESRKANTKAPTDIDGPKNLVTDQVTETTLSVSWDP-------------VE 731

  Fly   421 KDV------YLNVQAEPPTISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGG---- 475
            .|:      |.:...|...:..:....|||          :.|. :|.|:: :...|...|
Mouse   732 ADIDRYMVRYTSPDGETKEVPVSKDKSSTV----------LRGL-RPGVEY-KVDVWAQKGAQDS 784

  Fly   476 -RYNVQANGDLE------IQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVA 533
             :.|.:|..|::      .:.||.|.       |...:..::||....|..:|.:..|.:.:.|.
Mouse   785 RKANTKAPTDIDSPKNLVTEQVTEST-------ATVSWDPVEADIDRYVVRYTSVDGETREFLVG 842

  Fly   534 AGQSATFRCNEAHDDTLEIEIDWW--KDGQS---------IDFEAQPRFV--KTNDNSLTIA-KT 584
            ..|::|......  ..:|.::|.|  |..|.         .|.:.....|  :..:.:|::: ..
Mouse   843 KDQTSTVLTGMR--PGVEYQVDVWAQKGTQESRKTSTKAPTDIDGPKNLVTDQVTETTLSVSWDP 905

  Fly   585 MELDSGEYTCVARTRLDEATARANLIVQDVP-----NAPKLTGITCQAD-KAEIHWEQQG--DNR 641
            :|.|...| .|..|..|..|       ::||     ::..|.|:....: |.:: |.|:|  |:|
Mouse   906 VEADIDRY-MVRYTSPDGET-------KEVPVSKDKSSTVLRGLRPGVEYKVDV-WAQKGAQDSR 961

  Fly   642 -----------SPILHYTIQFNTSFTPASWD----------AAYEKVPNTDSSFVV--------- 676
                       ||......|...:....|||          ..|.........|::
Mouse   962 KANTKAPTDIDSPKNLAIDQVTETTLSVSWDPVQADIDRYVVRYTSADGESKEFLIGKEQRSTVL 1026

  Fly   677 -QMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEI 740
             .:.|...|..      ::.|...:..|....|:......:|.|:|......|...|||.|:
Mouse  1027 TGLRPGVEYKV------EVWAQKGARESKKANTEGHTDIDSPKNLVTNQVTENTATISWDPV--- 1082

  Fly   741 EHNAPNFHYYVSW------KRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGES 799
              .|....|.|.:      .|:||...         .:::.|:......|:|.::|.|.....||
Mouse  1083 --QADIDRYMVRYTSADGETREIPVRK---------EKSSTVLTGLRPGVEYTVQVWAQKGARES 1136

  Fly   800 NVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEE 864
            ..|..:.      ...:|:|.|....::|.:|: .::|.|     ||.:...|.:: :|..:||
Mouse  1137 KKAKTKA------PTEIDSPKNLVTNRVTENTA-TISWDP-----VRANIDRYMVR-YTSADGE- 1187

  Fly   865 GLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPS---AVIDFDTPEGVPSPVQGLDAY 926
             .:||.|..|..:.::|..||..:....:.|..|......:   |:.:.|.|       :.|..:
Mouse  1188 -TKEIPVSKDQSSTILTGLKPGMEYTIHVWAQKGARESKKADTKALTEIDPP-------RNLRPF 1244

  Fly   927 PLGSSAFMLHWKKPLYPNGKLTGYKIYYE----EVKESYV--GERR----EYDPHITDPRVTRMK 981
            .:..|..:|.|   |.|:.::.||.:.|:    .|||..:  |::|    :.:..:|.|    :.
Mouse  1245 GVTHSGGVLTW---LPPSAQIDGYILTYQFPNGTVKEVELPRGQQRFELQDLEQGVTYP----VS 1302

  Fly   982 MAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPA---------------------TP 1025
            :...|.|.:.|...|..:.:.....|..:.:.::...|.|..                     |.
Mouse  1303 LVAFKGNQRSRTVSTTLSTVDARFPHPSDCSQVQQNTNAASGLYTIYLNGDASRPMQVYCDMDTD 1367

  Fly  1026 SFSWEQLPSDN-GLAKFRINWLPSTE--GHPGTHFF--------------TMHRIKGETQWIREN 1073
            ...|......| |...|...|....|  |.|...|:              |.:.::.:.|...|:
Mouse  1368 GGGWIVFQRRNTGQLDFFKRWRSYVEGFGDPMKEFWLGLDKLHNLTTGTTTRYEVRADLQTFNES 1432

  Fly  1074 EEKNSDYQEVGGLDPETAYEFRVVSVDG--------HFNTESATQEIDTNTVEGPIMVANETVAN 1130
            .....|:.:|.  ..:..|:..|....|        |...:..|.:.|.:     |.::|..:.:
Mouse  1433 AYAVYDFFQVA--SSKERYKLSVGKYRGTAGDALTYHNGWKFTTFDRDND-----IALSNCALTH 1490

  Fly  1131 AG--WFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQP 1188
            .|  |:....||                |..|||.  :.:.:.|....|.:|  ||:|.|
Mouse  1491 HGGWWYKNCHLA----------------NPNGKYG--ETKHSEGVNWEPWKG--HEFSIP 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	15/75 (20%)
		IG_like	57..127	CDD:214653	15/72 (21%)
		Ig	135..214	CDD:299845	21/115 (18%)
		IG_like	141..216	CDD:214653	22/111 (20%)
		ig	251..332	CDD:278476	16/97 (16%)
		I-set	339..427	CDD:254352	17/101 (17%)
		Ig	354..427	CDD:299845	15/86 (17%)
		I-set	432..517	CDD:254352	17/95 (18%)
		Ig	446..517	CDD:299845	14/81 (17%)
		I-set	522..611	CDD:254352	19/102 (19%)
		ig	525..609	CDD:278476	19/97 (20%)
		FN3	613..707	CDD:238020	22/132 (17%)
		FN3	716..807	CDD:238020	22/96 (23%)
		fn3	817..905	CDD:278470	22/87 (25%)
		FN3	917..1004	CDD:238020	20/96 (21%)
		FN3	1041..1111	CDD:238020	16/93 (17%)
		Bravo_FIGEY	1155..>1221	CDD:290593	11/34 (32%)
Tnn	NP_808507.2	EGF_2	<142..166	CDD:285248
		EGF_2	169..197	CDD:285248
		EB	181..233	CDD:279949
		EGF_2	233..259	CDD:285248
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470	18/90 (20%)
		fn3	444..521	CDD:278470	13/77 (17%)
		FN3	532..608	CDD:214495	22/106 (21%)
		FN3	620..696	CDD:214495	15/96 (16%)
		fn3	708..785	CDD:278470	18/101 (18%)
		fn3	796..875	CDD:278470	17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	868..888		2/19 (11%)
		fn3	884..961	CDD:278470	18/85 (21%)
		fn3	972..1049	CDD:278470	11/82 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1044..1063		2/18 (11%)
		FN3	1060..1136	CDD:214495	19/89 (21%)
		fn3	1148..1225	CDD:278470	22/85 (26%)
		fn3	1236..1313	CDD:278470	20/90 (22%)
		FReD	1327..1539	CDD:238040	41/231 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000