DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Prtg

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001032740.2	Gene:	Prtg / 315806	RGDID:	1307157	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	1453	Identity:	290/1453 - (19%)
Similarity:	476/1453 - (32%)	Gaps:	506/1453 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILAALLVALLCAGSAESKGNRPPRITKQPAPG-----ELLFKVAQQNK--ESDNPFIIECEADGQ 64
            :|..||:.||           ||   ....||     ||.|....|:.  ...:|..::|:|.|:
  Rat     9 MLPLLLLLLL-----------PP---LGSVPGVWSFSELFFMKEPQDATVTRKDPVFLDCQAHGE 59

  Fly    65 PEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIP-----KDEDRGHYQCFASNEFGTATSNS 124
            ...:.:|:|||.|..    :|:.::....|:|.|:..     :..|.|.|||.|.|::|...|..
  Rat    60 GPIKVTWLKNGAKLS----ENKRIQVLSNGSLYISEAEGRRGEQSDEGFYQCLAVNKYGAILSQK 120

  Fly   125 VYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLD 189
            .::..:.::||:.....| |..||......|.. ...|...:.|....:   ::....:||:|..
  Rat   121 AHLTLSTISAFEVHPVST-EVPEGGVARFSCKI-SSTPPAVITWEFNRT---ALPMTMDSRVTAL 180

  Fly   190 PEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRR 254
            |.|.|...:...|||..   |.|.|.:                                 :..:|
  Rat   181 PSGVLQIYDAGPEDAGK---YRCVAAT---------------------------------HAHKR 209

  Fly   255 QSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDV 319
            :|:.                                         .||.|...|
  Rat   210 KSME-----------------------------------------ASLTIVPAN----------- 222

  Fly   320 SNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIH-NGKPIEQST 383
                 ..:||       .:|.....|:..||:..:.||.||.|.|.|:|.|||.. :.|.|:  .
  Rat   223 -----ETRSF-------YMPTIIASPQNVTASLHQTVVLECMATGYPKPIISWSRLDHKSID--V 273

  Fly   384 PNPRRTVTDNTIRIINLVK-GDTGNYGCNAT--NSLGYVYKDVYLNVQAEPPTISEAPAAVSTVD 445
            .|.|  |..|...||:.|| ...|.|.|.||  .:..:......|.|.| ||:..|.|.:::...
  Rat   274 FNTR--VLGNGNLIISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLA-PPSFVEWPESLTRPR 335

  Fly   446 GRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQ 510
            .......|:..|.|.|.:.||:      .|| .:.:||.
  Rat   336 AGTARFVCQAEGIPSPKMSWLK------NGR-RIHSNGR-------------------------- 367

  Fly   511 ADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTN 575
                                                                         :|..
  Rat   368 -------------------------------------------------------------IKMY 371

  Fly   576 DNSLTIAKTMELDSGEYTCVARTRLDEATARANLIV---QDVPNAP-KLTGITCQADKAEIHWEQ 636
            ::.|.|.:.:..|...|.|:|........:||.|.|   :|.|:|| .:...|..:....:.||:
  Rat   372 NSKLVINQIIPEDDAIYQCMAENSQGSVLSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWER 436

  Fly   637 QGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVV--QMSPWANYTFRVIAFNKIGASPP 699
            ...|...::.|::.:..:  ....:..|:.|...|::..:  .:.|.:||||.::|:..:|||..
  Rat   437 PLYNSDKVIAYSVHYMKA--EGLNNEEYQVVLGNDTTHYIIDDLEPDSNYTFYIVAYMPMGASQM 499

  Fly   700 SAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWEN 764
            |.|....|.: |||.:.|: :......|.:::|||.|:|..........|.:|::..
  Rat   500 SDHVTQNTLE-DVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLS-------- 554

  Fly   765 NNIFDWRQNNIVIADQPTFVK------------YLIKVVAIN--DRGESNV-------AAEEVVG 808
                  .:|:|.:.:.|..|.            ||:::.|..  ..|||:|       .|..|..
  Rat   555 ------TENSIQVVELPGTVHEYLLEGLEPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKA 613

  Fly   809 YSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEE--SVRGHFKGYKIQTWTENEGEEGLREIH- 870
            ....:..|: |.|.|...:        .|...:|:  ::||:...||         |||.:| |
  Rat   614 PKSPELHLE-PLNCTTISV--------RWLQDTEDPAAIRGYKLFYK---------EEGQQE-HG 659

  Fly   871 -VKGDTHNALVT--QFKPDSKNYARILAYNGRFNG--------PPSAVIDFDTPEGVPSPVQGLD 924
             :..||.:.|.|  ...|..|.:.|:||||...:|        .|..|...|.....|.|...|.
  Rat   660 PIFLDTGDLLYTLSGLDPRRKYHVRLLAYNNLEDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLY 724

  Fly   925 AYPLGSSAFMLHWKKPLYPNGKLTGYKI-------------YYEEVKESYVGERREYDPHITDPR 976
            |....||:..|||::|.:...::..|.|             .|.:..|
  Rat   725 AKANTSSSIFLHWRRPAFTTAQVINYTIRCNPVGLQNASLVLYLQTSE----------------- 772

  Fly   977 VTRMKMAGLKPNSKYRISITA-TTKMGEGSEHYIEKTTLKDAVNVAPA----------TPSFSWE 1030
             |.|.:.||:||:||..::.. ..::.......:..|||.:|....|.          |...||:
  Rat   773 -THMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHTTLPEAPTGPPVGVKVTLIEDDTALVSWK 836

  Fly  1031 QLPSDNG---------LAKFRINWLPSTEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGL 1086
              |.|..         |...|..|:..       .:..:||....|..:.||....:.|
  Rat   837 --PPDGPETVVTRYTILYASRKAWIAG-------EWQVLHREGAITMALLENLVAGNVY------ 886

  Fly  1087 DPETAYEFRVVSVDGHFNTESATQEID----TNTVEGPIMVANETVAN--------------AGW 1133
                     :|.:       ||:.|:.    :|:||..::..:.:.:|              :|:
  Rat   887 ---------IVKI-------SASNEVGEGPFSNSVELAVLPKDASESNQRPKRLDSSDAKVYSGY 935

  Fly  1134 F---------IGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPL 1189
            :         |.:.:.:|...||..::.:|.|::..|... .:...:|             :|||
  Rat   936 YHLDQKSMTGIAVGVGIALTCILICVLILIYRSKARKSSA-SKTTQSG-------------TQPL 986

  Fly  1190 DNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTAVATAAARAAAAARSKLTSLPT---------- 1244
            ...||   ||::.:..|...:                   ||.....|.:..:|:
  Rat   987 SRASA---SVAAGSDMGKNLE-------------------RATENEESSVPMMPSCFIDAKGGTD 1029

  Fly  1245 ----------------------STQQQQQQQQQQQQQQE----QPQSTSASTVPLISLASPSPSP 1283
                                  .|::.:.:|.|::..|.    ||    .:||.:....||| ||
  Rat  1030 LIINSYGPIIKNNPKKKWRFFQDTKKIKVEQTQRRITQTVCFYQP----GTTVLISDEDSPS-SP 1089

  Fly  1284 SSTSNSPTAAPPSYELCVADAEH 1306
            ..|::.|....|:    ..|.||
  Rat  1090 GQTTSFPRPFGPT----TLDTEH 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	21/77 (27%)
		IG_like	57..127	CDD:214653	21/74 (28%)
		Ig	135..214	CDD:299845	19/78 (24%)
		IG_like	141..216	CDD:214653	19/74 (26%)
		ig	251..332	CDD:278476	8/80 (10%)
		I-set	339..427	CDD:254352	31/91 (34%)
		Ig	354..427	CDD:299845	27/76 (36%)
		I-set	432..517	CDD:254352	13/84 (15%)
		Ig	446..517	CDD:299845	10/70 (14%)
		I-set	522..611	CDD:254352	10/88 (11%)
		ig	525..609	CDD:278476	9/83 (11%)
		FN3	613..707	CDD:238020	23/96 (24%)
		FN3	716..807	CDD:238020	21/111 (19%)
		fn3	817..905	CDD:278470	26/101 (26%)
		FN3	917..1004	CDD:238020	22/100 (22%)
		FN3	1041..1111	CDD:238020	11/69 (16%)
		Bravo_FIGEY	1155..>1221	CDD:290593	11/65 (17%)
Prtg	NP_001032740.2	Ig	32..124	CDD:416386	26/95 (27%)
		Ig strand A	32..35	CDD:409353	2/2 (100%)
		Ig strand A'	38..44	CDD:409353	1/5 (20%)
		Ig strand B	48..58	CDD:409353	3/9 (33%)
		Ig strand C	62..68	CDD:409353	1/5 (20%)
		Ig strand C'	70..73	CDD:409353	1/2 (50%)
		Ig strand D	78..83	CDD:409353	0/4 (0%)
		Ig strand E	85..91	CDD:409353	3/5 (60%)
		Ig strand F	103..110	CDD:409353	4/6 (67%)
		Ig strand G	114..124	CDD:409353	2/9 (22%)
		Ig	131..218	CDD:416386	24/168 (14%)
		Ig strand B	146..150	CDD:409353	0/3 (0%)
		Ig strand C	159..163	CDD:409353	0/3 (0%)
		Ig strand E	183..187	CDD:409353	2/3 (67%)
		Ig strand F	197..202	CDD:409353	2/7 (29%)
		Ig strand G	211..214	CDD:409353	1/43 (2%)
		Ig_3	230..302	CDD:404760	28/75 (37%)
		Ig strand B	247..251	CDD:409353	2/3 (67%)
		Ig strand C	260..264	CDD:409353	2/3 (67%)
		Ig strand E	282..286	CDD:409353	0/3 (0%)
		Ig strand F	296..301	CDD:409353	2/4 (50%)
		I-set	322..407	CDD:400151	23/178 (13%)
		Ig strand C	352..357	CDD:409353	1/4 (25%)
		Ig strand C'	359..362	CDD:409353	2/3 (67%)
		Ig strand D	367..371	CDD:409353	1/90 (1%)
		Ig strand E	373..378	CDD:409353	1/4 (25%)
		Ig strand F	387..394	CDD:409353	3/6 (50%)
		Ig strand G	398..407	CDD:409353	3/8 (38%)
		FN3	414..507	CDD:238020	22/94 (23%)
		FN3	512..605	CDD:238020	21/107 (20%)
		fn3	619..694	CDD:394996	26/93 (28%)
		FN3	721..809	CDD:238020	20/105 (19%)
		FN3	816..906	CDD:238020	20/120 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	974..1018		12/79 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1078..1193		12/36 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910