DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Igsf9b

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001363879.1	Gene:	Igsf9b / 315510	RGDID:	1564717	Length:	1441	Species:	Rattus norvegicus

Alignment Length:	1171	Identity:	247/1171 - (21%)
Similarity:	385/1171 - (32%)	Gaps:	358/1171 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQSTILAAL-----LVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECE 60
            :|..:|::|::     |||.:..|..|    .|..:|.:...|                .::.|:
  Rat     2 IWYVATLIASVISTRGLVAQVAHGLRE----EPEFVTARAGEG----------------VVLRCD 46

  Fly    61 ----ADGQPEP-EYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTA 120
                ..|||.| ...|.|.|                      :.||.....|:|......|
  Rat    47 VIHPVTGQPPPYVVEWFKFG----------------------VPIPIFIKFGYYPPHVDPE---- 85

  Fly   121 TSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSR 185
                 |..:|.|:   |:|:..||.|..|
  Rat    86 -----YAGRASLH---DKASLRLEQVRSE------------------------------------ 106

  Fly   186 MTLDPEGNLWFS-NVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQ 249
                .:|  |:. .|...|...|.::.             |:.|.|.:   ....:..:.||  |
  Rat   107 ----DQG--WYECKVLMLDQQYDTFHN-------------GSWVHLTI---NAPPTFTETPP--Q 147

  Fly   250 YVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDR--ITQGHYGKSLVIRQTNFDDA 312
            |:..::     |..:.:.|...|.|.|...|.|:|..:..|.:  ::.|    ||.:...:.:|.
  Rat   148 YIEAKE-----GGSITMTCTAFGNPKPIVTWLKEGTLLSASGKYQVSDG----SLTVTSVSREDR 203

  Fly   313 GTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVP-EPKISWIHNG 376
            |.|||...:..|.|...:.:| |...|:....||..|....::.:..|||...| ....:|....
  Rat   204 GAYTCRAYSIQGEAVHTTHLL-VQGPPFIVSPPENITVNISQDALLTCRAEAYPGNLTYTWYWQD 267

  Fly   377 KPIE-QSTPNPR-RTVTDNTIRIINLVKGDTGNYGCNATNSLG-YVYKDVYLNVQAEPPTISEAP 438
            :.:. |:....| |.:.|.|:.|..:...|.|.|.|..:|||| ......||.|| .|..:...|
  Rat   268 ENVYFQNDLKLRVRILIDGTLIIFRVKPEDAGKYTCVPSNSLGRSPSASAYLTVQ-YPARVLNMP 331

  Fly   439 AAVSTVDGRNVTIKCRVNGS-PKPLVKWLRASNWLTGGR---------YNVQANGDLEIQDVTFS 493
            ..:....|.:..|:|.|:.. |..:|||.:      .||         :.:..:|.:.|::.|..
  Rat   332 PVIYVPVGIHGYIRCPVDAEPPATVVKWNK------DGRPLQVEKNLGWTLMEDGSIRIEEATEE 390

  Fly   494 DAGKYTCYAQNKFGEI--QADGSLVVKEHTRITQEP-QNYEVAAGQSATFRCNEAHDDTLEIEID 555
            ..|.|||...|..|.:  .|...||:|:....|..| ..|...||:.....| .|..|...: |.
  Rat   391 ALGTYTCVPYNTLGTMGQSAPARLVLKDPPYFTVLPGWEYRQEAGRELLIPC-AAAGDPFPV-IT 453

  Fly   556 WWKDGQSIDFEAQPRFVKTN---DNSLTIAKTMELDSGEYTCVARTRLDEATARANL-IVQDVPN 616
            |.|.|       :|...|.|   ..||......:.|.||:.|||...:...||..:| ::...|:
  Rat   454 WRKVG-------KPSRSKHNALPSGSLQFRALSKEDHGEWECVATNVVTSITASTHLTVIGTSPH 511

  Fly   617 APKLTGITCQADKAEIHWEQQGD----NRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVV- 676
            ||....:......|.:.||...|    ....:.:..:.....|.|..|.:.  .||...|..:|
  Rat   512 APGSVRVHVSMTTANVSWEPGYDGGYEQTFSVWYGPLMKRAQFGPHDWLSL--SVPLGPSWLLVD 574

  Fly   677 QMSPWANYTFRVIAFNKIGASPPSAHSDSCT--------TQPD-VPFKNPDNVVGQGTEPNNLVI 732
            .:.|...|.|.|:|.|::|.   ||.|:..|        |.|: :....|...:........:::
  Rat   575 SLEPETAYQFSVLAQNRLGT---SAFSEVVTVNTLAFPVTTPEPLVLVTPPRCLTANRTQQGVLL 636

  Fly   733 SWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVK-------YLIKV 790
            ||  :|...|:.|...|.:.::   ....||   :.|   :.|...|...|.|       |..:|
  Rat   637 SW--LPPANHSFPIDRYIMEFR---VGERWE---MLD---DAIPGTDGEFFAKDLSQDTWYEFRV 690

  Fly   791 VAIND---RGESNVAAEEVVGYSGED-------------RPL----------------------- 816
            :|:..   ...||:|     |.|..|             ||:
  Rat   691 LAVMQDLISEPSNIA-----GVSSTDIFPQPDLTDDGLARPVLAGIVATICFLAAAILFSTLAAC 750

  Fly   817 --------------DAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGL- 866
                          |.|.:.|  ....|....::...||.||:|      .::..:|:..::|.
  Rat   751 FVNKQRKRKLKRKKDPPLSIT--HCRKSLESPLSSGKVSPESIR------TLRAPSESSDDQGQP 807

  Fly   867 -----------REIHVKGDTHNALVTQFKPDSKNYARILAY----------NGRFNGPPSAVIDF 910
                       :|:.:...|..|:.::....:|..|...|.          :|||...||
  Rat   808 AAKRMLSPTREKELSLYKKTKRAISSRKYSVAKAEAEAEATTPIELISRGPDGRFVMGPS----- 867

  Fly   911 DTPEGVPSPVQG--LDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHIT 973
               |..|| |:|  ::.:|......|       ||                    |.|:.|....
  Rat   868 ---EMEPS-VKGRRIEGFPFAEETDM-------YP--------------------EFRQSDEENE 901

  Fly   974 DPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPA-TPSFSWEQLPSDNG 1037
            ||.|. ..:|.|||.         .|.|....:.|:.          .|| :|.|....|...:|
  Rat   902 DPLVP-TSVAALKPQ---------LTPMSSSQDSYLP----------PPAYSPRFQPRGLEGPSG 946

  Fly  1038 L 1038
            |
  Rat   947 L 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	14/77 (18%)
		IG_like	57..127	CDD:214653	13/74 (18%)
		Ig	135..214	CDD:299845	11/79 (14%)
		IG_like	141..216	CDD:214653	9/75 (12%)
		ig	251..332	CDD:278476	19/82 (23%)
		I-set	339..427	CDD:254352	25/91 (27%)
		Ig	354..427	CDD:299845	21/76 (28%)
		I-set	432..517	CDD:254352	22/96 (23%)
		Ig	446..517	CDD:299845	21/82 (26%)
		I-set	522..611	CDD:254352	26/93 (28%)
		ig	525..609	CDD:278476	24/87 (28%)
		FN3	613..707	CDD:238020	24/98 (24%)
		FN3	716..807	CDD:238020	20/100 (20%)
		fn3	817..905	CDD:278470	20/109 (18%)
		FN3	917..1004	CDD:238020	20/88 (23%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Igsf9b	NP_001363879.1	PHA03247	<898..1246	CDD:223021	17/70 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..1044		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1111..1332
		Ig	41..115	CDD:319273	24/149 (16%)
		I-set	139..225	CDD:369462	24/97 (25%)
		Ig	229..321	CDD:386229	25/91 (27%)
		Ig	<353..414	CDD:386229	16/66 (24%)
		Ig	438..502	CDD:319273	20/72 (28%)
		FN3	510..605	CDD:238020	25/99 (25%)
		FN3	621..703	CDD:238020	17/92 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..821		11/66 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910