DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrg and cntn2

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_571521.1	Gene:	cntn2 / 30726	ZFINID:	ZDB-GENE-990630-12	Length:	1040	Species:	Danio rerio

Alignment Length:	1064	Identity:	284/1064 - (26%)
Similarity:	467/1064 - (43%)	Gaps:	126/1064 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RQSTILAALLVALLCAGSA------ESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEA 61
            |...:|..|.::.|...:|      ||..:..|...:||:  .|::....    .:....:.|:|
Zfish     2 RMRILLCLLSLSFLALSNALGGDVCESGHDSGPVFEEQPS--SLIYPEGM----PEGKVTLGCQA 60

  Fly    62 DGQPEPEYSWIKNGK--KFDWQAYDNRMLRQPGRGTLVITIPKD-EDRGHYQCFASNEFGTATSN 123
            ...|...|.|..||.  .|..:::..::     .|.|||..|:: .|.|.|||.|.|..||..|.
Zfish    61 RSSPAAVYRWRVNGTDISFAEESHYTQV-----AGNLVINNPQNGRDGGSYQCLAINRCGTIVSR 120

  Fly   124 SVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTL 188
            ...::...|..|..|:.......||....|.|..|..:|:.:..|.|.|..:           .:
Zfish   121 VANLKFGYLRDFPPESRSPQTVHEGMGTFLACQPPAHYPALSYRWFINEFPN-----------FI 174

  Fly   189 DPE----------GNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGV--SASQ 241
            .||          |||:.:|....|..:  |:..:..::..|...|.:|.:    |:.|  .||.
Zfish   175 QPEAGRWFVSQVTGNLYLANARANDTGN--YFCFTTINMDVSTKSIFSKAV----QLTVHPDASP 233

  Fly   242 NKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKS----- 301
            .|..|..:.....::.||.|:..:|.|.....|:|:..|.|       .|.|.....|.|
Zfish   234 RKTAPNIRVRFPAETYALSGQTAQLECFAYRNPIPKIRWRK-------VDGILPPKVGTSVDGPI 291

  Fly   302 LVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTK-----EPEIATAAEDEEVVFECR 361
            |:|.:.||||.|.|.|:|.|..|. ::....::|.:.|.:.:     |.||::     |:.:.|.
Zfish   292 LIIPELNFDDEGMYECEVYNSEGR-ETHQGRVSVQAQPDWLQVMSDSEVEISS-----ELQWSCA 350

  Fly   362 AAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLN 426
            |||.|.|.|.|:.||..:   ....|..|.:..::|.||...|:|.|.|.|.|....:|.:..|.
Zfish   351 AAGKPRPTIRWLRNGHAL---ITQDRVEVNNGRLKIANLALEDSGMYQCVAENKHSTIYSNAELR 412

  Fly   427 VQAEPPTISEAPA--AVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGG-RYNVQANGDLEIQ 488
            ||.:.|.....|.  .|....|..|.::|:...:|||.:.|.|.:..||.. |..|..:|.|.|.
Zfish   413 VQVQAPDFRLNPVRKLVPAARGGQVKMECKPRAAPKPTLFWSRGTELLTNSTRITVTPDGILWIY 477

  Fly   489 DVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIE 553
            :::.:|.|||||:|:|..|:..:.|.|.|::.|:||..|.|.::..|::||.:|:.:||.|:::.
Zfish   478 NISRADEGKYTCFAENYLGKANSTGHLSVRDATKITLAPSNADINQGENATLQCHASHDPTMDLT 542

  Fly   554 IDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELD-----SGEYTCVARTRLDEATARANLIVQD 613
            ..|..:|..:|.|......:..:...||...:.::     :|.|||.|:|.:|.|.|.|.|:|:.
Zfish   543 FTWSLNGVPLDLEEPNGHYRRMEGKETIGDLVIVNGQLSHAGTYTCTAQTVVDSAMASAKLVVRG 607

  Fly   614 VPNAPKLTGITCQAD-KAEIHWEQQGDNRSPILHYTIQFNTSFT---------PASWDAAYEKVP 668
            .|..|....:|...| ..|:.|.:..||.|||..|.|...:|.|         ||:.:.
Zfish   608 PPGPPGGLVVTSVNDTSVELRWSRGYDNHSPIGKYVILGRSSQTHDWKRMRTDPANIEG------ 666

  Fly   669 NTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVIS 733
            |.:|:.|:.:.||.:|.|:|||.|.:|:..||..|....|:...|...|..:.|.|...|.|:|:
Zfish   667 NAESARVIDLRPWMDYEFQVIASNILGSGEPSMPSPRAQTKEAAPTVAPSGLGGGGGNRNELIIT 731

  Fly   734 WTPMPEIEHNAPNFHYYVSW-KRDIPAAAWENNNIFDWRQNNIVIADQ--PTFVKYLIKVVAIND 795
            ||||.....|..:|.|.::: |:.||  .|....:.:...:..|.::.  ..:..:.:::.|.|.
Zfish   732 WTPMAREYQNGDSFGYILAFRKQGIP--TWTVVKVPNVESSRYVYSNDSLTAYCPFEVRIKAYNK 794

  Fly   796 RGESNVAAEEVVGYSGEDRPLDAP-----TNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQ 855
            :||...:...|| :|.|:.|..:|     |..|..:|      .::|.|:...::.|..:||:|:
Zfish   795 KGEGPFSQIAVV-HSAEEEPTVSPRWINATALTAFEI------QVSWEPIQHLNINGVLRGYEIR 852

  Fly   856 TWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPV 920
            .|.::|.|.....:...|..:.|.||..:|::..:..:||||....||.|......|.:..|:..
Zfish   853 YWRQHEREAAADRVRTAGLENTARVTGLRPNTLYHITVLAYNSAGTGPASPRTTVITKKPPPNRP 917

  Fly   921 QGLDAYPLGSSAFMLHWK--KPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMA 983
            .|..::.:..|...:.|.  |.:.....:.|||:.|:...:|.:        .:.:...|.:|:.
Zfish   918 PGNVSWKVDGSWVTVRWDHVKSMDNESAVLGYKVLYKHEGQSAL--------KVLEKSKTSVKLP 974

  Fly   984 GLKPNSKYRISITATTKMGEGSEH 1007
            ..|.|....:.|.:....|:|:.|
Zfish   975 LPKDNGYVVLEIRSWGDGGDGAAH 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	23/75 (31%)
		IG_like	57..127	CDD:214653	23/72 (32%)
		Ig	135..214	CDD:299845	19/88 (22%)
		IG_like	141..216	CDD:214653	17/84 (20%)
		ig	251..332	CDD:278476	25/85 (29%)
		I-set	339..427	CDD:254352	28/92 (30%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	29/87 (33%)
		Ig	446..517	CDD:299845	26/71 (37%)
		I-set	522..611	CDD:254352	28/93 (30%)
		ig	525..609	CDD:278476	25/88 (28%)
		FN3	613..707	CDD:238020	32/103 (31%)
		FN3	716..807	CDD:238020	22/93 (24%)
		fn3	817..905	CDD:278470	24/92 (26%)
		FN3	917..1004	CDD:238020	16/88 (18%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
cntn2	NP_571521.1	Ig1_Contactin-2	33..126	CDD:143258	27/103 (26%)
		I-set	34..125	CDD:254352	27/101 (27%)
		Ig	128..225	CDD:299845	23/113 (20%)
		IG_like	138..227	CDD:214653	21/105 (20%)
		Ig	238..325	CDD:299845	26/94 (28%)
		IG_like	245..324	CDD:214653	25/86 (29%)
		Ig	329..413	CDD:299845	27/91 (30%)
		IG_like	335..413	CDD:214653	27/85 (32%)
		IG_like	429..506	CDD:214653	27/76 (36%)
		Ig5_Contactin_like	434..506	CDD:143170	26/71 (37%)
		I-set	511..605	CDD:254352	28/93 (30%)
		Ig6_Contactin-2	525..606	CDD:143262	23/80 (29%)
		FN3	615..702	CDD:238020	29/92 (32%)
		FN3	714..806	CDD:238020	22/93 (24%)
		FN3	817..909	CDD:238020	25/97 (26%)
		FN3	917..1002	CDD:238020	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810