DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and l1camb

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_571458.1	Gene:	l1camb / 30656	ZFINID:	ZDB-GENE-980526-512	Length:	1269	Species:	Danio rerio

Alignment Length:	1257	Identity:	375/1257 - (29%)
Similarity:	577/1257 - (45%)	Gaps:	147/1257 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFDWQAYDNRM 87
            :|..:.|..|.||.| ...|.:...|        :.|||.|.|.|.:.|:|:||:|      ..:
Zfish    44 NKLKQAPEFTTQPVP-HTAFSLDDVN--------LACEASGDPSPSFRWVKDGKQF------GEV 93

  Fly    88 LRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVE-GEPF 151
            |.:.|..|...|:.....:|.|:|:|:||.|||.||.|::....:.:......:...|.| ||..
Zfish    94 LSESGTLTPHPTMDLHFYQGTYRCYAANELGTAVSNLVHLTTEPVPSLAKVKKQKRRAYEVGESA 158

  Fly   152 MLKCAAPDGFPSPTVNWMIQESIDGSIKSIN-NSRMTLDPEGNLWFSNVTREDASSDFYYACSAT 215
            :|:|..|....:|.::||     |.....|. |.|:|:..:|||:|:|:...|:..|  |.|:|
Zfish   159 VLRCNPPKSSVTPKIHWM-----DMQFHHIPLNERVTISRDGNLYFANLIANDSRDD--YTCNA- 215

  Fly   216 SVFRSEYKIGNKVLLDVKQMGV------SASQNKHPPVRQYVSRRQS-LALRGKRMELFCIYGGT 273
                  :.|...::|..:.|.:      |..:|:...:......|.| |.|||:.:.|.||..|.
Zfish   216 ------HYINASIILPKEPMSIYVTPSNSVVKNRRAKLHHPAGARSSYLVLRGQTLTLECIPEGL 274

  Fly   274 PLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSV 338
            |.|:..|.:....:. .:|..:.:..:.|.|......|.|.|.|...|. .|:......:.|.:.
Zfish   275 PTPEVHWDRIDSALS-PNRTKKLYNNRWLQIDNVLESDDGEYVCTARNS-ENSVKHHYTVTVEAA 337

  Fly   339 PYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKG 403
            ||:|:.||....|..|.|..:|:|.|:|.|.|:|..||.|:..:..:|||.|:...:.:.|:...
Zfish   338 PYWTRRPEEHLYAPGETVRLDCQADGIPAPNITWSINGVPVSGTDVDPRRRVSSGKLILSNVEFS 402

  Fly   404 DTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVD--------GRNVTIKCRVNGSPK 460
            ||..|.|.|.|..|.:..:.:::|       .|.||.:.|.|        |:.|.:.||..|||.
Zfish   403 DTAVYQCEAVNKHGSILINTHVHV-------VELPAQILTPDERLYQATAGQTVMLDCRTFGSPL 460

  Fly   461 PLVKW--LRASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRI 523
            |.:.|  |.:...|:..:.:...||.|:|.:|:..|:.:|||........|.|:  |.|...|:|
Zfish   461 PKIHWEILDSIPALSNAKISQMTNGSLKISNVSEEDSNRYTCSVSETNKSISAE--LEVLNRTKI 523

  Fly   524 TQEPQNYEVAAGQSATFRCNEAHDDTLEI-EIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMEL 587
            ...|||..|..|..|...|....|..|:. .:.|.|||..|............:.||.:......
Zfish   524 VGPPQNLHVIRGSDAILHCKYTVDHNLKSPTVQWKKDGHKITASTSNDKYHEIEGSLKVLDVQME 588

  Fly   588 DSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKA-EIHWEQQGDNRSPILHYTIQF 651
            |.|.|:|...|.||..||...:.|||.|:.|:...::.:.::: .|.|....:|.||:..|.|:.
Zfish   589 DMGIYSCGVSTTLDSDTASGYITVQDKPDPPQSLKLSEKMERSVTISWMPSVENNSPVTEYVIEM 653

  Fly   652 NTSFTP--ASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPF 714
            |...||  ..|. .|..|........:.:.|::.|.|::.|.|.||.|.||..|.|.:|....|.
Zfish   654 NEGETPDEGQWQ-KYRSVSQDIRQLEIHLQPYSKYHFQIRAVNSIGTSAPSESSLSYSTPAAKPD 717

  Fly   715 KNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAA-WENNNIFDWRQNN--IV 776
            :||:||:...|:|.:::|||..|...:.|.|.|.|.|.|:|...:.| |..:::     :|  ::
Zfish   718 RNPENVMTLSTDPKSMIISWQEMDRRQFNGPGFQYKVFWRRAADSGAHWTESSV-----SNPPLL 777

  Fly   777 IADQPTFVKYLIKVVAINDRGESNVAAEE---VVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWT 838
            :.:..|||.:.|||.|:||.|    ||.|   |:||||||.||:||:..::.:: ..||..:.|:
Zfish   778 VNNTGTFVSFEIKVQAVNDLG----AAPEPLTVIGYSGEDFPLEAPSALSVTEL-QKTSVMVRWS 837

  Fly   839 PVSEESVRGHFKGYKIQTWTENEGEEG-LRE-----------IHVKGDTHNALVTQFKPDSKNYA 891
            ||..||||||..||||  :...:|..| ||.           |.|..|....:|:..:..|....
Zfish   838 PVRPESVRGHLLGYKI--YLRMKGPSGRLRAGRSPAVGNPTVIEVPADAAEKIVSDLQYYSDYTL 900

  Fly   892 RILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEE 956
            .|.|:|.:..||.|....|.||||.|.||..|.......|...|.|:.|..|||::.||.:.|:|
Zfish   901 TITAFNSKGEGPHSEESSFSTPEGAPGPVLFLPFDSPSESEITLRWEAPHKPNGEIRGYLLQYQE 965

  Fly   957 VKESYVG-ERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNV 1020
            |   .:| |..::...|..|.||...:..|.|.|:|...::|....|:|:.......||.|.
Zfish   966 V---VIGSESPQHVESIDLPAVTEFTLKNLNPESRYTFHLSARNSAGDGAPAIQSGATLLDG--- 1024

  Fly  1021 APATPSFSWEQLPSDNGLAKFRINWLP-STEGHPGTHFFTMHRIKGETQWIRENEEKNSD--YQE 1082
              ..||.    :....|.....::|:| ....:.|..|..:.:|:| .:| .|:|:.||.  :.:
Zfish  1025 --EPPSV----INMTAGETSVNLSWVPGDRHRNVGFSFRYLKKIEG-AEW-EESEKINSTQAFYQ 1081

  Fly  1083 VGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIM-VANETVANAGWFIGMMLALAFIII 1146
            :.|||....|..:|:|       .:.:.:.|..|:..|.. .:....|..|||||::.||..:::
Zfish  1082 LQGLDSGVIYHLQVLS-------GNTSYDWDFKTIYSPEWHKSPRNFATEGWFIGLISALVLLLL 1139

  Fly  1147 LFIIICIIRRNRGGKYDVHDRELANG--RRDYPEEGGFHEY------------SQPLDNKSAGRQ 1197
            :.:::|.|::::||||.|.|:|...|  .....::..|.||            |||     :|.:
Zfish  1140 VLLLLCYIKKSKGGKYSVKDKEEGQGDAANQKLKDDAFGEYRSLESDMEKCSISQP-----SGCE 1199

  Fly  1198 SVSSANKPGVESDTDSMAEYGD 1219
            |..|:|        ||:|:|||
Zfish  1200 SKRSSN--------DSLADYGD 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	27/72 (38%)
		IG_like	57..127	CDD:214653	27/69 (39%)
		Ig	135..214	CDD:299845	24/80 (30%)
		IG_like	141..216	CDD:214653	25/76 (33%)
		ig	251..332	CDD:278476	22/81 (27%)
		I-set	339..427	CDD:254352	30/87 (34%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	28/94 (30%)
		Ig	446..517	CDD:299845	23/72 (32%)
		I-set	522..611	CDD:254352	26/89 (29%)
		ig	525..609	CDD:278476	25/84 (30%)
		FN3	613..707	CDD:238020	28/96 (29%)
		FN3	716..807	CDD:238020	33/96 (34%)
		fn3	817..905	CDD:278470	31/99 (31%)
		FN3	917..1004	CDD:238020	28/87 (32%)
		FN3	1041..1111	CDD:238020	17/72 (24%)
		Bravo_FIGEY	1155..>1221	CDD:290593	24/79 (30%)
l1camb	NP_571458.1	Ig	69..133	CDD:299845	27/69 (39%)
		Ig	140..231	CDD:299845	28/104 (27%)
		IG_like	255..334	CDD:214653	21/80 (26%)
		Ig3_L1-CAM	265..335	CDD:143284	16/71 (23%)
		IG_like	344..426	CDD:214653	27/81 (33%)
		Ig	352..427	CDD:299845	25/81 (31%)
		IG_like	441..517	CDD:214653	23/77 (30%)
		IGc2	446..505	CDD:197706	20/58 (34%)
		I-set	522..607	CDD:254352	25/84 (30%)
		IGc2	535..595	CDD:197706	15/59 (25%)
		FN3	616..706	CDD:238020	25/90 (28%)
		FN3	719..798	CDD:214495	29/83 (35%)
		FN3	817..921	CDD:238020	33/106 (31%)
		FN3	926..1014	CDD:238020	29/90 (32%)
		FN3	1025..>1095	CDD:238020	18/75 (24%)
		Bravo_FIGEY	1148..1233	CDD:290593	24/79 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I9229
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1108
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm24295
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740