DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and l1cama

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_571436.2	Gene:	l1cama / 30634	ZFINID:	ZDB-GENE-990415-10	Length:	1271	Species:	Danio rerio

Alignment Length:	1338	Identity:	379/1338 - (28%)
Similarity:	599/1338 - (44%)	Gaps:	134/1338 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLVALLCAGSAESKGN---------------RPPRITKQPAPGELLFKVAQQNKESDNPFIIEC 59
            |||:.||....|...||               .||.||.||         ......|.:...:.|
Zfish    18 ALLLPLLLLAVALKPGNTTINIPSRYKIRDLKSPPVITAQP---------KSVTTFSADDITLTC 73

  Fly    60 EADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITI---PKDEDRGHYQCFASNEFGTAT 121
            :|.|.|.|.:.|:|:|.:|| .:.|..:......||..:|.   |..:.:|.|.|:||||.|||.
Zfish    74 DATGNPPPTFRWVKDGVEFD-PSKDPDLSVSRDSGTFSLTAKDGPIHQYQGRYNCYASNELGTAV 137

  Fly   122 SNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSI-NNSR 185
            ||...:........:.|...|.:..|||..:|.|..|:|..:|.::||     |..::.| .|.|
Zfish   138 SNEARIVTENTPTLQKEKIITKKVEEGESVVLPCNPPNGTVAPVIHWM-----DKKLRHIQQNER 197

  Fly   186 MTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPP-VRQ 249
            :....:|||:||:.|..|:..|  |.|:.........|:...:.|.|.... |..:|:.|. :|.
Zfish   198 VIQGRDGNLYFSHATVADSRDD--YTCNIQFPSARVIKLKEPIKLTVSSSN-SVVRNRRPQMMRP 259

  Fly   250 YVSRRQSLALRGKRMELFCIYGGTPLPQTVW-SKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAG 313
            ..|....|.|.|:.:||.||..|.|.|...| .|||  :....|.|:....:.|..:..:..|.|
Zfish   260 TGSSSSYLVLSGQNLELECIVQGLPSPSIQWIRKDG--VLSESRTTKDSNDRVLRFQNISETDGG 322

  Fly   314 TYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKP 378
            .|.|..:|..| ..:.:..:.|.:.||:.|||:....|..|.|..||:|.|:|:|:::|..||..
Zfish   323 EYQCTATNPQG-MSTHTYRVTVEAAPYWIKEPKSQLYAPGETVKLECKADGIPKPEVTWSINGIL 386

  Fly   379 IEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTI-SEAPAAVS 442
            :....|:|||:|....:.:.|:...||..:.|.|.:..|.|..:.|:.|...||.| :|.....|
Zfish   387 LSDIDPDPRRSVKHGVLTLKNVELSDTAVFQCKAASKHGSVLINAYVYVIELPPQILTEDGLMYS 451

  Fly   443 TVDGRNVTIKCRVNGSPKPLVKWLRASNW--LTGGRYNVQ-ANGDLEIQDVTFSDAGKYTCYAQN 504
            ..:|:...:.|...|||:|.|.| ...:|  |...:..:| ::|.|:|.:.:.:|:|:|||...|
Zfish   452 VAEGQTTELACETFGSPRPNVTW-EGESWGALVANQRMIQLSDGSLQISNASLNDSGQYTCTVNN 515

  Fly   505 KFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEI-EIDWWKDGQSIDFEAQ 568
              .:|.....|.|...|.|.:.|....:..|:.||..|....|...:: ::.|.|:.|.:...:.
Zfish   516 --SKITITAELDVLNKTVIVKPPLALRIQRGKPATLTCEYQVDSRQDLPQVQWRKNTQKLTESSD 578

  Fly   569 PRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQAD-KAEI 632
            ......::::|.|.:..|.|.|.|||...|.||.|.|..::.:.|.|:.|.|..:|...: :..:
Zfish   579 SDKYMIDESTLIIPEVEEEDEGTYTCEVITTLDMAKASGSITIVDRPDPPSLIQMTEPKERRVTL 643

  Fly   633 HWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGA 696
            .|....|:.||:|.|.|:| .|......|: ...:|..:.....:.:.|:.:|.|||||.|:||.
Zfish   644 SWTPGADHNSPVLEYLIEFEETGSDRKEWE-ELSRVSGSSQRATLPLKPFISYRFRVIAINEIGK 707

  Fly   697 SPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAA- 760
            |.||..:::.:|....|..||:.|.....||..|||:|..|.....|.|:|||.|.|::.:.:.
Zfish   708 SDPSMVTEAYSTPAAPPDSNPEGVRSDSDEPGTLVITWKEMDRRSFNGPDFHYKVMWRKVLGSGP 772

  Fly   761 AWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMR 825
            :|...:|   .....|:.|...|..:.|||.|:|:.|| ....:.::||||||.||:||.:..:.
Zfish   773 SWHTKDI---TSPPFVVTDVGNFSAFDIKVQAVNEMGE-GPEPKSIIGYSGEDYPLEAPLDVGLI 833

  Fly   826 QITSSTSGYMAWTPVSEESVRGHFKGYKIQ-TWTENEGEEGLRE------IHVKGDTHNALVTQF 883
            .| :||:..:.|..|:.|:|||..:||||. |:...:|:...||      :....:....::...
Zfish   834 LI-NSTAIKVTWAAVNRETVRGRLQGYKIYLTYLGPKGQHLRREPKTTFVVTTDSNEEKKVLGDL 897

  Fly   884 KPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLT 948
            :|.|.....:..:|.:..||.|..|.|.||||||.|...|.......:...:||..|..|||.|.
Zfish   898 QPFSHYNLAVSVFNYKGEGPQSESILFFTPEGVPGPPSSLMLDSPSETEMTVHWTPPNQPNGNLI 962

  Fly   949 GYKIYYEEVKESYVGERREYDP------HITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEH 1007
            ||.:.::::         :.|.      .|:||..:..|:. |.|:|:||..:...|.:|||
Zfish   963 GYILQHQQL---------DNDASLMQVVKISDPTASHYKLK-LDPHSRYRFYLRGYTAIGEG--- 1014

  Fly  1008 YIEKTTLKD-AVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIK--GETQW 1069
               ...:|| |..:.|..||    .:....|.....:.|: |.|......|| :|.::  |..:|
Zfish  1015 ---LPIIKDGATTLDPVPPS----DISISTGETSVNLTWV-SKERQRNVEFF-IHYLRKDGPDKW 1070

  Fly  1070 IRENEEKNS--DYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANAG 1132
             .::|:.||  .:..:.||.|.:.|..::     .||.....|||  .|....:|..........
Zfish  1071 -EKSEKVNSTQSFYTLHGLQPGSQYRLKI-----DFNNTKWEQEI--QTAGARVMEVKSGFVTES 1127

  Fly  1133 WFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGR- 1196
            ||||::.||..::::.:|:|.|:|::||||.|.::          |||.....::|::|::.|.
Zfish  1128 WFIGLISALVLLLLVLLILCFIKRSKGGKYSVKEK----------EEGQIDSEARPMNNEAFGEY 1182

  Fly  1197 QSVSSANKPGVESDTDSMAEYGDGDTAVATAAARAAAAARSKLTSLPTSTQQQQQQQQQQQQQQE 1261
            :|:.|.|:....:...|:.|    |:.:.|.            ..|.........|.:....:..
Zfish  1183 RSLESDNEEKRTASQPSLCE----DSKLCTD------------DGLDDYANSNSVQTEVIMDESL 1231

  Fly  1262 QPQSTSASTVPLISLASPSPSPSSTSNSPTAAPPSYEL 1299
            ..||:....||.......||...:|:.|....|.|..|
Zfish  1232 ASQSSGVRDVPDAETQESSPLNPATAISHHGLPNSAAL 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	27/75 (36%)
		IG_like	57..127	CDD:214653	27/72 (38%)
		Ig	135..214	CDD:299845	26/79 (33%)
		IG_like	141..216	CDD:214653	25/75 (33%)
		ig	251..332	CDD:278476	24/81 (30%)
		I-set	339..427	CDD:254352	30/87 (34%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	26/88 (30%)
		Ig	446..517	CDD:299845	22/73 (30%)
		I-set	522..611	CDD:254352	23/89 (26%)
		ig	525..609	CDD:278476	22/84 (26%)
		FN3	613..707	CDD:238020	29/95 (31%)
		FN3	716..807	CDD:238020	29/91 (32%)
		fn3	817..905	CDD:278470	24/94 (26%)
		FN3	917..1004	CDD:238020	24/92 (26%)
		FN3	1041..1111	CDD:238020	17/73 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	17/66 (26%)
l1cama	NP_571436.2	Ig_L1-CAM_like	69..144	CDD:319299	27/75 (36%)
		Ig	147..241	CDD:386229	27/100 (27%)
		Ig	274..344	CDD:386229	20/72 (28%)
		Ig	361..436	CDD:386229	24/74 (32%)
		IG_like	450..526	CDD:214653	23/78 (29%)
		Ig	547..616	CDD:319273	19/68 (28%)
		FN3	625..717	CDD:238020	28/92 (30%)
		FN3	726..817	CDD:238020	29/94 (31%)
		FN3	825..926	CDD:238020	27/101 (27%)
		FN3	931..1024	CDD:238020	29/108 (27%)
		FN3	1027..>1098	CDD:238020	19/77 (25%)
		Bravo_FIGEY	1150..1234	CDD:372781	21/109 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.880