DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and PRTG

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_776175.2	Gene:	PRTG / 283659	HGNCID:	26373	Length:	1150	Species:	Homo sapiens

Alignment Length:	1431	Identity:	276/1431 - (19%)
Similarity:	460/1431 - (32%)	Gaps:	465/1431 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESD-------NPFIIECEADGQ 64
            :|.|||:.||.:                |.||...|......||..       :|.:::|:|.|:
Human    17 LLRALLLLLLLS----------------PLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGE 65

  Fly    65 PEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVIT-----IPKDEDRGHYQCFASNEFGTATSNS 124
            ...:.:|:|||.|..    :|:.:.....|:|.|:     ..:..|.|.|||.|.|::|...|..
Human    66 VPIKVTWLKNGAKMS----ENKRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQK 126

  Fly   125 VYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLD 189
            .::..:.::||:.:...| |..||
Human   127 AHLALSTISAFEVQPIST-EVHEG----------------------------------------- 149

  Fly   190 PEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYVSRR 254
                    .|.|        :||..:|                           |||.
Human   150 --------GVAR--------FACKISS---------------------------HPPA------- 164

  Fly   255 QSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDV 319
                      .:...:..|.||.|:           ||||....| .|.|...:..|:|.|.|
Human   165 ----------VITWEFNRTTLPMTM-----------DRITALPTG-VLQIYDVSQRDSGNYRC-- 205

  Fly   320 SNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTP 384
                                       ||..........|.....:|..:....|.
Human   206 ---------------------------IAATVAHRRKSMEASLTVIPAKESKSFHT--------- 234

  Fly   385 NPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNV 449
                                                           |||...|..::|...:.|
Human   235 -----------------------------------------------PTIIAGPQNITTSLHQTV 252

  Fly   450 TIKCRVNGSPKPLVKWLRASN-WLTGGRYNVQANGDLEIQDVTFSDAGKYTCYA----QNKFGEI 509
            .::|...|:|||::.|.|..: .:......|..||:|.|.||....||.|.|.|    ...|...
Human   253 VLECMATGNPKPIISWSRLDHKSIDVFNTRVLGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVA 317

  Fly   510 QADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKT 574
            .|  :|.|.......:.|::.......:|.|.|..  :.....::.|.|:|:.|....:   :|.
Human   318 MA--TLTVLAPPSFVEWPESLTRPRAGTARFVCQA--EGIPSPKMSWLKNGRKIHSNGR---IKM 375

  Fly   575 NDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIV---QDVPNAP-KLTGITCQADKAEIHWE 635
            .::.|.|.:.:..|...|.|:|........:||.|.|   :|.|:|| .:...|..:....:.||
Human   376 YNSKLVINQIIPEDDAIYQCMAENSQGSILSRARLTVVMSEDRPSAPYNVHAETMSSSAILLAWE 440

  Fly   636 QQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVV--QMSPWANYTFRVIAFNKIGASP 698
            :...|...::.|::.:..:  ....:..|:.|...|::..:  .:.|.:||||.::|:..:|||.
Human   441 RPLYNSDKVIAYSVHYMKA--EGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQ 503

  Fly   699 PSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWE 763
            .|.|....|.: |||.:.|: :......|.:::|||.|:|..........|.:|::..
Human   504 MSDHVTQNTLE-DVPLRPPE-ISLTSRSPTDILISWLPIPAKYRRGQVVLYRLSFRLS------- 559

  Fly   764 NNNIFDWRQNNIVIADQPTFVK------------YLIKVVAIN--DRGESNV-------AAEEVV 807
                   .:|:|.:.:.|....            ||:::.|..  ..|||:|       .|..|.
Human   560 -------TENSIQVLELPGTTHEYLLEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVK 617

  Fly   808 GYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVK 872
            .....:..|: |.|.|...:        .|....|::..  .:|||:....|.:.|.|    .:.
Human   618 APKSPELHLE-PLNCTTISV--------RWQQDVEDTAA--IQGYKLYYKEEGQQENG----PIF 667

  Fly   873 GDTHNALVT--QFKPDSKNYARILAYNGRFNG--------PPSAVIDFDTPEGVPSPVQGLDAYP 927
            .||.:.|.|  ...|..|.:.|:||||...:|        .|..|...|.....|.|...|.|..
Human   668 LDTKDLLYTLSGLDPRRKYHVRLLAYNNIDDGYQADQTVSTPGCVSVRDRMVPPPPPPHHLYAKA 732

  Fly   928 LGSSAFMLHWKKPLYPNGKLTGYKI-------------YYEEVKESYVGERREYDPHITDPRVTR 979
            ..||:..|||::|.:...::..|.|             .|.:..|                  |.
Human   733 NTSSSIFLHWRRPAFTAAQIINYTIRCNPVGLQNASLVLYLQTSE------------------TH 779

  Fly   980 MKMAGLKPNSKYRISITA-TTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWE--QLPSDNGLAKF 1041
            |.:.||:||:||..::.. ..::.......:..:||.:    |||.|....:  .:..|..|
Human   780 MLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPE----APAGPPVGVKVTLIEDDTAL--- 837

  Fly  1042 RINWLP----------------STEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPET 1090
             ::|.|                |.:......:..:||....|..:.||....:.|
Human   838 -VSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNVY---------- 891

  Fly  1091 AYEFRVVSVDGHFNTESATQEID----TNTVEGPIMVANETVAN--------------AGWF--- 1134
                 :|.:       ||:.|:.    :|:||..::....:.:|              :|::
Human   892 -----IVKI-------SASNEVGEGPFSNSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLD 944

  Fly  1135 ------IGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGF----HEYSQPL 1189
                  |.:.:.:|...||..::.:|.|::..|... .:...||.:..|.....    :|..:.|
Human   945 QKSMTGIAVGVGIALTCILICVLILIYRSKARKSSA-SKTAQNGTQQLPRTSASLASGNEVGKNL 1008

  Fly  1190 DNKSAGRQSVSSANKPG----VESDTDSMA-EYGDGDTAVATAAARAAAAARSKLTSLPTSTQQQ 1249
            :......:|:.....|.    .:..||.:. .||                        |......
Human  1009 EGAVGNEESLMPMIMPNSFIDAKGGTDLIINSYG------------------------PIIKNNS 1049

  Fly  1250 QQQ----QQQQQQQQEQPQSTSASTVPLIS-----LASPSPSPSSTSNSPTAAPPSYELCVADAE 1305
            :::    |..::.|.||||......|....     |.|...||||...:.:.:.|..  ..||.|
Human  1050 KKKWFFFQDSKKIQVEQPQRRFTPAVCFYQPGTTVLISDEDSPSSPGQTTSFSRPFG--VAADTE 1112

  Fly  1306 H 1306
            |
Human  1113 H 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	21/77 (27%)
		IG_like	57..127	CDD:214653	21/74 (28%)
		Ig	135..214	CDD:299845	9/78 (12%)
		IG_like	141..216	CDD:214653	8/74 (11%)
		ig	251..332	CDD:278476	15/80 (19%)
		I-set	339..427	CDD:254352	5/87 (6%)
		Ig	354..427	CDD:299845	3/72 (4%)
		I-set	432..517	CDD:254352	28/89 (31%)
		Ig	446..517	CDD:299845	23/75 (31%)
		I-set	522..611	CDD:254352	18/88 (20%)
		ig	525..609	CDD:278476	17/83 (20%)
		FN3	613..707	CDD:238020	23/96 (24%)
		FN3	716..807	CDD:238020	20/111 (18%)
		fn3	817..905	CDD:278470	23/97 (24%)
		FN3	917..1004	CDD:238020	22/100 (22%)
		FN3	1041..1111	CDD:238020	12/85 (14%)
		Bravo_FIGEY	1155..>1221	CDD:290593	13/74 (18%)
PRTG	NP_776175.2	Ig	40..130	CDD:299845	24/93 (26%)
		Ig	139..223	CDD:299845	30/226 (13%)
		IG_like	141..223	CDD:214653	30/224 (13%)
		IG_like	241..323	CDD:214653	25/83 (30%)
		IGc2	250..309	CDD:197706	20/58 (34%)
		I-set	327..412	CDD:254352	18/89 (20%)
		Ig	345..412	CDD:299845	16/71 (23%)
		FN3	419..512	CDD:238020	22/94 (23%)
		FN3	517..610	CDD:238020	20/107 (19%)
		fn3	624..699	CDD:278470	23/89 (26%)
		FN3	726..814	CDD:238020	20/105 (19%)
		FN3	821..911	CDD:238020	17/115 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1002		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1150		10/30 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910