DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrg and CNTN6

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001276009.1	Gene:	CNTN6 / 27255	HGNCID:	2176	Length:	1028	Species:	Homo sapiens

Alignment Length:	1102	Identity:	306/1102 - (27%)
Similarity:	486/1102 - (44%)	Gaps:	133/1102 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQSTILAALLVALLCAGSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQP 65
            :|:     ..:|:.|:.:.:.:...:||  |..| .|.:::|.:.....|    .|:.|.|:|.|
Human     4 LWK-----LVILLPLINSSAGDGLLSRP--IFTQ-EPHDVIFPLDLSKSE----VILNCAANGYP 56

  Fly    66 EPEYSWIKNGKKFDW-QAYDNRMLRQPGRGTLVITIP-KDEDRGHYQCFASNEFGTATSNSVYVR 128
            .|.|.|.:||...|: .:|..|:    ..|:|.|..| .|:|.|.|||.|:|..||..|....::
Human    57 SPHYRWKQNGTDIDFTMSYHYRL----DGGSLAINSPHTDQDIGMYQCLATNLLGTILSRKAKLQ 117

  Fly   129 KAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNW-------MIQESIDGSIKSINNSRM 186
            .|.:..|:.:...|:...||:..:|.|..|..|...:..|       .:||         :|.|.
Human   118 FAYIEDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQE---------DNRRF 173

  Fly   187 TLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQYV 251
            .....|||:.:.|...|..:   |.|..|:........|....|..:..||.........|| :.
Human   174 VSQETGNLYIAKVEPSDVGN---YTCFITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVR-FP 234

  Fly   252 SRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQ-TNF--DDAG 313
            ...|  |.:...::|.|...|.|:|...|    :|:..|....:..|.||..|.: .||  :|.|
Human   235 ETIQ--AAKDSSVKLECFALGNPVPDISW----RRLDGSPLPGKVKYSKSQAILEIPNFQQEDEG 293

  Fly   314 TYTCDVSNGVG-NAQSFSIILNVNSVPYFTKEPEIATAAED------EEVVFECRAAGVPEPKIS 371
            .|.|..||..| |.....:|        |...||.....::      :.:::||:|:|.|.|..:
Human   294 FYECIASNLRGRNLAKGQLI--------FYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYT 350

  Fly   372 WIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISE 436
            |:.||   |:..|..|..:.:.|:.|..|...|:|.|.|.|.|....:|.:..|.|.|..|..|:
Human   351 WLKNG---ERLNPEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPDFSK 412

  Fly   437 APAAVSTV--DGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKY 498
            :|....:.  .|.::.|.|:.|..|:..:.|.|.:..| ...|..:..:|.|:|.::|.||||.|
Human   413 SPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSY 477

  Fly   499 TCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSI 563
            ||.|.|:||..:..|||:|||.|.||..|...:|..|:|....|..:||.::|:...|:.:|..|
Human   478 TCIATNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVI 542

  Fly   564 DF-EAQPRFVKTNDNSL--TIAKTMEL-DSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGI- 623
            |. :....|.:....|:  .:.:.::| .||:|.|..:|.|:..:|.|::||:..|..|:...:
Human   543 DLKKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSAVADIIVRGPPGPPEDVQVE 607

  Fly   624 TCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP-----NTDSSFVVQMSPWAN 683
            ...:..:::.|....||.|||..:|||..|.|: ..|.|. ..||     .|.::.||.:|||..
Human   608 DISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFS-VGWQAV-ATVPEILNGKTYNATVVGLSPWVE 670

  Fly   684 YTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFH 748
            |.|||:|.|.||...||..|:...|:..||...|.|:.|.|...:.|||:|..:||...|...|.
Human   671 YEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESIPEELQNGEGFG 735

  Fly   749 YYVSWKRDIPAAAWENNNI-------FDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEV 806
            |.:.: |.:.:..|....:       |.:|..:|:     ....:.:||...|:.||.:::...:
Human   736 YIIMF-RPVGSTTWSKEKVSSVESSRFVYRNESII-----PLSPFEVKVGVYNNEGEGSLSTVTI 794

  Fly   807 VGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHV 871
            | |||||.|..||.. |..|..|::...::|..::.....|...||::..||::..|..:.:|.|
Human   795 V-YSGEDEPQLAPRG-TSLQSFSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRV 857

  Fly   872 KGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLH 936
            .|:.....:|..|.::..:|.:.|||....||.|..::..|.:..||......|:.|.:|...|:
Human   858 SGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTNSKLCLN 922

  Fly   937 WK--KPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKP-NSKYRISITAT 998
            |:  |.:....::.||||.|.        :.|:...||.:...|..::  |.| ...|.|.|...
Human   923 WEHVKTMENESEVLGYKILYR--------QNRQSKTHILETNNTSAEL--LVPFEEDYLIEIRTV 977

  Fly   999 TKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTM 1060
            :..|:||                    |....::|..:.|:...|.:|     .|.|||.::
Human   978 SDGGDGS--------------------SSEEIRIPKMSSLSSRGIQFL-----EPSTHFLSI 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	28/74 (38%)
		IG_like	57..127	CDD:214653	27/71 (38%)
		Ig	135..214	CDD:299845	20/85 (24%)
		IG_like	141..216	CDD:214653	19/81 (23%)
		ig	251..332	CDD:278476	24/84 (29%)
		I-set	339..427	CDD:254352	26/93 (28%)
		Ig	354..427	CDD:299845	23/72 (32%)
		I-set	432..517	CDD:254352	30/87 (34%)
		Ig	446..517	CDD:299845	27/71 (38%)
		I-set	522..611	CDD:254352	25/92 (27%)
		ig	525..609	CDD:278476	23/87 (26%)
		FN3	613..707	CDD:238020	34/99 (34%)
		FN3	716..807	CDD:238020	23/97 (24%)
		fn3	817..905	CDD:278470	23/87 (26%)
		FN3	917..1004	CDD:238020	23/89 (26%)
		FN3	1041..1111	CDD:238020	6/20 (30%)
		Bravo_FIGEY	1155..>1221	CDD:290593
CNTN6	NP_001276009.1	Ig	26..118	CDD:325142	34/102 (33%)
		Ig	120..214	CDD:325142	22/105 (21%)
		Ig	227..315	CDD:325142	27/102 (26%)
		Ig	319..403	CDD:325142	24/86 (28%)
		Ig	424..496	CDD:325142	27/71 (38%)
		Ig	515..598	CDD:325142	22/82 (27%)
		FN3	598..691	CDD:238020	33/94 (35%)
		FN3	703..796	CDD:238020	24/99 (24%)
		FN3	805..898	CDD:238020	24/93 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..908		6/20 (30%)
		FN3	906..991	CDD:238020	24/114 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10657
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810