DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Nfasc

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_006529697.2	Gene:	Nfasc / 269116	MGIID:	104753	Length:	1466	Species:	Mus musculus

Alignment Length:	1366	Identity:	407/1366 - (29%)
Similarity:	610/1366 - (44%)	Gaps:	212/1366 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ALLVALLCAGSA---------ESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQP 65
            ||::.||..|.|         :::..:||.||||.....::       ...|| .:|||||.|.|
Mouse   115 ALILFLLSLGGAIEIPMDPSIQNELTQPPTITKQSVKDHIV-------DPRDN-ILIECEAKGNP 171

  Fly    66 EPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPK----DEDRGHYQCFASNEFGTATSNSVY 126
            .|.:.|.:|.:.|: .|.|.|:..:...|||||....    :|..|.|||||.|:||||.||.:.
Mouse   172 APSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRIR 235

  Fly   127 VRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSI-NNSRMTLDP 190
            ::.::...:..|....:...||.|..|:|..|.|.|||.:.||     ..|::.| .:.|::...
Mouse   236 LQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM-----SSSMEPITQDKRVSQGH 295

  Fly   191 EGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGV--SASQNKHPPV---RQY 250
            .|:|:||||..:|..:|  |:|:|...|....:..|...|.|.....  .:|...||.:   |..
Mouse   296 NGDLYFSNVMLQDMQTD--YSCNARFHFTHTIQQKNPFTLKVLTNNPYNDSSLRNHPDIYSARGV 358

  Fly   251 VSRRQS-----------LALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVI 304
            ..|..|           :.|||..:.|.||..|.|.|...|.|.|..:. |::....::.|:|.|
Mouse   359 AERTPSFMYPQGTSSSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP-SNKAKFENFNKALRI 422

  Fly   305 RQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPK 369
            ...:.:|:|.|.|..||.:|:.: .:|.:.|.:.||:..||:....|..|:....|||.|.|:|.
Mouse   423 TNVSEEDSGEYFCLASNKMGSIR-HTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKPT 486

  Fly   370 ISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTI 434
            :.|:.||:|::.:.|||.|.|..:||...:........|.||.:|..||:..:.:::|...||.:
Mouse   487 VQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRM 551

  Fly   435 SEAPAAVSTVDGRNVT-IKCRVNGSPKPLVKWLR---ASNWLTGGRYNVQANGDLEIQDVTFSDA 495
            ..|...:..|...|.| :.|...|||.|.::|.:   .|| |.||.|:|..||.|||:.:...|.
Mouse   552 LSARNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN-LDGGNYHVYENGSLEIKMIRKEDQ 615

  Fly   496 GKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDG 560
            |.|||.|.|..|:.:....|.||:.|||.:.|::.....|.:....|...||.:|::.:.|.||.
Mouse   616 GIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVAKRGTTVQLECRVKHDPSLKLTVSWLKDD 680

  Fly   561 QSIDFEAQPRFV----KTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIV---------- 611
                   :|.::    |..|:||||....|.|.|.|||:|.|.||:..|:|.|.|
Mouse   681 -------EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCMASTELDQDLAKAYLTVLADQATPTNR 738

  Fly   612 -----QDVPNAPKLTGITCQADKA-EIHWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPN 669
                 :..|:.|:...:|..|::: .:.|....||.|||..|.:|| ...|.|..|. .:.:.|.
Mouse   739 LAALPKGRPDRPRDLELTDLAERSVRLTWIPGDDNNSPITDYVVQFEEDQFQPGVWH-DHSRFPG 802

  Fly   670 TDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISW 734
            :.:|.|:.:||:.||.|||||.|::|:|.||..|:...|....|..||.:|.|:||..||:.|:|
Mouse   803 SVNSAVLHLSPYVNYQFRVIAVNEVGSSHPSLPSERYRTSGAPPESNPSDVKGEGTRKNNMEITW 867

  Fly   735 TPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGES 799
            |||.......||..|.|.|:|......|  ||:..| .:..|:...|.:|.|.|:|.|.||.|:
Mouse   868 TPMNATSAFGPNLRYIVKWRRRETRETW--NNVTVW-GSRYVVGQTPVYVPYEIRVQAENDFGK- 928

  Fly   800 NVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEE 864
            ....:.::||||||.|..|||...:| :.:||:..:.|..|..::|:|..:.|:...|.|:...:
Mouse   929 GPEPDTIIGYSGEDYPRAAPTEVKIR-VLNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLLK 992

  Fly   865 GL------REIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGL 923
            .|      ::....||....:|.:..|.|.....::..|||.:||.|...:|.|||||||..:..
Mouse   993 NLWVSQKRQQASFPGDRPRGVVARLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRF 1057

  Fly   924 DAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPN 988
            ...........|.|..|.:|||.|.||.:.|.....:.:|::...:   ..|..|:..:....|.
Mouse  1058 RVRQPNLETINLEWDHPEHPNGILIGYILRYVPFNGTKLGKQMVEN---FSPNQTKFSVQRADPV 1119

  Fly   989 SKYRISITATTKMGEGS-----------------------------------------EHYIEKT 1012
            |:||.|::|.|::|.|.                                         ....|.|
Mouse  1120 SRYRFSLSARTQVGSGEAATEESPAPPNEATPTAAPPTLPPTTVGTTGLVSSTDATALAATSEAT 1184

  Fly  1013 TLKDAVNVAPATPSFS-----------------------------WEQLPSDNGLAKFRI----N 1044
            |:.....|.|.|.:.:                             .|..|.:..:....:    .
Mouse  1185 TVPIIPTVVPTTVATTIATTTTTTAATTTTTTTESPPTTTAGTKIHETAPDEQSIWNVTVLPNSK 1249

  Fly  1045 WLPSTEGH---PGTHFFTMHRIKGETQWIRENEEK-------NSDYQEVGGLDPETAYEFRVVSV 1099
            |...|..|   |||.|.        .::|..|..|       .:...::..|.|...|..||.|.
Mouse  1250 WANITWKHNFRPGTDFV--------VEYIDSNHTKKTVPVKAQAQPIQLTDLFPGMTYTLRVYSR 1306

  Fly  1100 DGH--------FNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRR 1156
            |..        |.|.:|.    ||.        ...:|..|||||:|.|:|.::::.:|:|.|:|
Mouse  1307 DNEGISSTVITFMTSTAY----TNN--------QADIATQGWFIGLMCAIALLVLILLIVCFIKR 1359

  Fly  1157 NRGGKYDVHD-RELANGRRDYPEEGGFHEYSQPLDNKS-AGRQSVSSANKPGVESDTDSMAEYGD 1219
            :|||||.|.: :::..|..|..||.|..:||.. |||. .|.|:.........||| ||:.:||:
Mouse  1360 SRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDE-DNKPLQGSQTSLDGTIKQQESD-DSLVDYGE 1422

  Fly  1220 G 1220
            |
Mouse  1423 G 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	33/76 (43%)
		IG_like	57..127	CDD:214653	33/73 (45%)
		Ig	135..214	CDD:299845	26/79 (33%)
		IG_like	141..216	CDD:214653	26/75 (35%)
		ig	251..332	CDD:278476	25/91 (27%)
		I-set	339..427	CDD:254352	29/87 (33%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	32/88 (36%)
		Ig	446..517	CDD:299845	29/74 (39%)
		I-set	522..611	CDD:254352	31/92 (34%)
		ig	525..609	CDD:278476	28/87 (32%)
		FN3	613..707	CDD:238020	34/95 (36%)
		FN3	716..807	CDD:238020	33/90 (37%)
		fn3	817..905	CDD:278470	24/93 (26%)
		FN3	917..1004	CDD:238020	23/86 (27%)
		FN3	1041..1111	CDD:238020	20/91 (22%)
		Bravo_FIGEY	1155..>1221	CDD:290593	27/68 (40%)
Nfasc	XP_006529697.2	Ig_hNeurofascin_like	161..237	CDD:143283	33/76 (43%)
		Ig	242..334	CDD:386229	29/98 (30%)
		Ig3_L1-CAM_like	383..453	CDD:319298	21/71 (30%)
		Ig	470..545	CDD:386229	24/74 (32%)
		Ig	568..634	CDD:319273	26/66 (39%)
		Ig	647..728	CDD:386229	29/87 (33%)
		FN3	747..837	CDD:238020	33/90 (37%)
		FN3	848..929	CDD:214495	33/84 (39%)
		FN3	947..1046	CDD:238020	26/99 (26%)
		FN3	1051..1142	CDD:238020	24/93 (26%)
		FN3	1241..1320	CDD:238020	18/86 (21%)
		Bravo_FIGEY	1358..1438	CDD:372781	27/68 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9875
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I994
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47974
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm43039
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16902
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760