DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrg and DIP-lambda

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001334747.1	Gene:	DIP-lambda / 26067049	FlyBaseID:	FBgn0267428	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	105/487 - (21%)
Similarity:	178/487 - (36%)	Gaps:	101/487 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 GKRMELFCIYGGTPLPQTVWSKDGQR---------IQWSDRITQGHYGKS---LVIRQTNFDDAG 313
            |:.:...|:.......:..|.|...:         :..:.|::..|.|.:   |.|.:...:|:|
  Fly    64 GRDISFTCVVDNLGHYRVAWIKSDSKAILGIHTHMVSLNPRLSVTHNGHNTWKLHISRVQINDSG 128

  Fly   314 TYTCDVSNGVGNAQS--FSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHN- 375
            :|.|.|:.....:.|  ..:::..:.:.:....||.....|...:...|...|||.||:.|...
  Fly   129 SYMCQVNTDPMKSLSGYLDVVVPPDILNHPEHNPEDGVCQEGGSISLMCSVTGVPRPKVLWRREA 193

  Fly   376 GKPIEQSTPNPRRT----VTDNTIRIINLVKGDTGNYGCNATNSL-GYVYK--DVYLNVQAEPPT 433
            ||.|...|....:|    |....:.:.|:.:.|.|.|.|.|:|.: ..|.|  :||:|..   ||
  Fly   194 GKEIILRTDGRDKTGFKSVEGERLVLTNVQRSDMGGYNCIASNGIPPSVSKRFNVYVNFS---PT 255

  Fly   434 ISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL---TGGRYNVQA--------NGDLEI 487
            :......|.....|.||::|.|...||||..|.|:...:   .|.:||:..        :.:|.|
  Fly   256 VKAISQLVGAPVEREVTLECIVEVFPKPLNGWYRSEGNIKLHNGNKYNISEEVINIYTWHLNLTI 320

  Fly   488 QDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTR----ITQEPQNYEVAAGQS----------- 537
            :.:|.||.|.|:|.:.|..|:.:   ||:..:..|    :|..|..:....|:|
  Fly   321 RHLTKSDFGTYSCSSVNALGKSE---SLIRLQELRLPPKLTTTPTPHMQTTGKSRRKHPASHKKG 382

  Fly   538 --ATFRCNEAH-DDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTR 599
              ...|..|.| .:.::.|.:...:|..:     .:|..:.::::.      |:||....:. .:
  Fly   383 LNEVLRFQETHFANQIQQENEDHNEGFDL-----LKFTNSENSNIV------LESGHINSMI-NK 435

  Fly   600 LDEATARANLIVQDVPNAPKLTGITCQADKAEIHW--EQQGDNRSPILHY-TIQFNTS------- 654
            .|..........|:..|.|..|     .......|  ...|..|..:..| |:...||
  Fly   436 EDVNIYHPKQYGQEKTNKPSGT-----IPSTRTPWILTNAGSQRPALTSYATVALITSFWLFFWR 495

  Fly   655 -FTPASWDA----------------AYEKVPN 669
             |....|||                :|.:.||
  Fly   496 VFHSLDWDAIRVSSVVHHVVVFKRRSYFEAPN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	15/84 (18%)
		I-set	339..427	CDD:254352	27/95 (28%)
		Ig	354..427	CDD:299845	24/80 (30%)
		I-set	432..517	CDD:254352	29/95 (31%)
		Ig	446..517	CDD:299845	26/81 (32%)
		I-set	522..611	CDD:254352	15/106 (14%)
		ig	525..609	CDD:278476	13/97 (13%)
		FN3	613..707	CDD:238020	17/84 (20%)
		FN3	716..807	CDD:238020
		fn3	817..905	CDD:278470
		FN3	917..1004	CDD:238020
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
DIP-lambda	NP_001334747.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010