DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrg and Cntn2

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:NP_037016.2 Gene:Cntn2 / 25356 RGDID:3821 Length:1040 Species:Rattus norvegicus


Alignment Length:1118 Identity:302/1118 - (27%)
Similarity:476/1118 - (42%) Gaps:155/1118 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RQSTILAALL--VALLCA-GSAESKGNRP---PRITKQPAPGELLFKVAQQNKESDNPFIIECEA 61
            :::::|..:|  |||:.: |.:.::|...   |...:||.  .|||    ..:.:::...:.|.|
  Rat     7 KKASLLLLVLATVALVSSPGWSFAQGTPATFGPIFEEQPI--GLLF----PEESAEDQVTLACRA 65

  Fly    62 DGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGR------GTLVITIP-KDEDRGHYQCFASNEFGT 119
            ...|...|.|..||         ..|..:||.      |.|||..| |.:|.|.|||.|||..||
  Rat    66 RASPPATYRWKMNG---------TDMNLEPGSRHQLMGGNLVIMSPTKTQDAGVYQCLASNPVGT 121

  Fly   120 ATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQE-----SIDGSIK 179
            ..|....:|...|..|..|....::..||...||.|..|..:|..:..|::.|     ..||   
  Rat   122 VVSKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDG--- 183

  Fly   180 SINNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSAS---- 240
                ........|||:   :.|.:||....|:|.|||......|   .|.....|:.::|.    
  Rat   184 ----RHFVSQTTGNLY---IARTNASDLGNYSCLATSHMDFSTK---SVFSKFAQLNLAAEDPRL 238

  Fly   241 -----QNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSK-DGQ-RIQWSDRITQGHY 298
                 :.:.||        ::.||.|:::.|.|...|.|:|:..|.| ||. ..||:..      
  Rat   239 FAPSIKARFPP--------ETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWATA------ 289

  Fly   299 GKSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAA 363
            ..:|.|...:|:|.|||.|:..|..|.......|: |.:.|.:.|......|.....:.:.|.||
  Rat   290 EPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRII-VQAQPEWLKVISDTEADIGSNLRWGCAAA 353

  Fly   364 GVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQ 428
            |.|.|.:.|:.||:|:....   |..|....:|...|...|:|.|.|.|.|..|.:|....|.||
  Rat   354 GKPRPMVRWLRNGEPLASQN---RVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQ 415

  Fly   429 AEPPTISEAPA--AVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDV 490
            |..|...:.|.  .:....|..::|.|:...:||..:.|.:.:..| ...|..|.::|.|.|:::
  Rat   416 ALAPDFRQNPVRRLIPAARGGEISILCQPRAAPKATILWSKGTEILGNSTRVTVTSDGTLIIRNI 480

  Fly   491 TFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEID 555
            :.||.|||||:|:|..|:..:.|.|.|::.|:||..|.:.::..|.:.|.:|:.:||.|:::...
  Rat   481 SRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGDNLTLQCHASHDPTMDLTFT 545

  Fly   556 WWKDGQSIDFEA-----QPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVP 615
            |..|...|||:.     :....|.....|||........|:|||:|:|.:|..:..|.::|:..|
  Rat   546 WTLDDFPIDFDKPGGHYRRASAKETIGDLTILNAQLRHGGKYTCMAQTVVDGTSKEATVLVRGPP 610

  Fly   616 NAPKLTGITCQAD-KAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKV--------PNTD 671
            ..|....:....| ..::.|.:..||.|||..||:|   :.||.|  ..:::|        .|.:
  Rat   611 GPPGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQ---ARTPPS--GKWKQVRTNPVNIEGNAE 670

  Fly   672 SSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTP 736
            ::.|:.:.||.:|.|||.|.|.:|...||..|....|:..||...|..:.|.|..|..|:|:|||
  Rat   671 TAQVLGLMPWMDYEFRVSASNILGTGEPSGPSSKIRTKEAVPSVAPSGLSGGGGAPGELIINWTP 735

  Fly   737 MPEIEHNAPNFHYYVSWKRDIPAAAWENNNI-------FDWRQNNIVIADQPTFVKYLIKVVAIN 794
            :.....|...|.|.:|::|. .:::|:...:       |.:..::|    || :..:.:|:.:.|
  Rat   736 VSREYQNGDGFGYLLSFRRQ-GSSSWQTARVPGADAQYFVYGNDSI----QP-YTPFEVKIRSYN 794

  Fly   795 DRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTE 859
            .||:...:...:| ||.|:.|..||.....:. :||:...::|.||.:: :.|...||:|:.|..
  Rat   795 RRGDGPESLTALV-YSAEEEPRVAPAKVWAKG-SSSSEMNVSWEPVLQD-MNGILLGYEIRYWKA 856

  Fly   860 NEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLD 924
            .:.|.....:...|...:|.||...|::|.:..:.|||....||.|...|..|.:..|....|..
  Rat   857 GDNEAAADRVRTAGLDTSARVTGLNPNTKYHVTVRAYNRAGTGPASPSADAMTVKPPPRRPPGNI 921

  Fly   925 AYPLGSSAFMLHWKK--PLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKP 987
            ::...||:..|.|..  ||.....:||||:.|:.            |.|.|..         |..
  Rat   922 SWTFSSSSLSLKWDPVVPLRNESTVTGYKMLYQN------------DLHPTPT---------LHL 965

  Fly   988 NSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSD-----NGLAKFRINWLP 1047
            .||..|.|.....:|..            .|.:....|  ..:.:|::     ||.....:....
  Rat   966 TSKNWIEIPVPEDIGHA------------LVQIRTTGP--GGDGIPAEVHIVRNGGTSMMVESAA 1016

  Fly  1048 STEGHPGTHFFTM 1060
            :...|||..|..|
  Rat  1017 ARPAHPGPAFSCM 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 27/79 (34%)
IG_like 57..127 CDD:214653 27/76 (36%)
Ig 135..214 CDD:299845 21/83 (25%)
IG_like 141..216 CDD:214653 20/79 (25%)
ig 251..332 CDD:278476 24/82 (29%)
I-set 339..427 CDD:254352 26/87 (30%)
Ig 354..427 CDD:299845 23/72 (32%)
I-set 432..517 CDD:254352 26/87 (30%)
Ig 446..517 CDD:299845 24/71 (34%)
I-set 522..611 CDD:254352 26/93 (28%)
ig 525..609 CDD:278476 24/88 (27%)
FN3 613..707 CDD:238020 30/102 (29%)
FN3 716..807 CDD:238020 23/97 (24%)
fn3 817..905 CDD:278470 24/87 (28%)
FN3 917..1004 CDD:238020 22/88 (25%)
FN3 1041..1111 CDD:238020 5/20 (25%)
Bravo_FIGEY 1155..>1221 CDD:290593
Cntn2NP_037016.2 Ig 37..133 CDD:416386 34/110 (31%)
Ig strand A 40..44 CDD:409353 0/3 (0%)
Ig strand A' 47..52 CDD:409353 3/8 (38%)
Ig strand B 58..66 CDD:409353 1/7 (14%)
Ig strand C 71..77 CDD:409353 2/5 (40%)
Ig strand C' 79..82 CDD:409353 1/11 (9%)
Ig strand D 89..93 CDD:409353 0/3 (0%)
Ig strand E 95..101 CDD:409353 4/5 (80%)
Ig strand F 108..117 CDD:409353 5/8 (63%)
Ig strand G 120..133 CDD:409353 4/12 (33%)
Ig2_Contactin-2-like 141..230 CDD:409392 25/101 (25%)
Ig strand B 153..157 CDD:409392 2/3 (67%)
Ig strand C 167..171 CDD:409392 0/3 (0%)
Ig strand E 192..196 CDD:409392 3/6 (50%)
Ig strand F 206..211 CDD:409392 2/4 (50%)
Ig strand G 224..227 CDD:409392 0/2 (0%)
Ig 241..326 CDD:416386 27/99 (27%)
Ig strand A 241..246 CDD:409353 0/4 (0%)
Ig strand A' 249..254 CDD:409353 1/12 (8%)
Ig strand B 257..266 CDD:409353 2/8 (25%)
Ig strand C 272..276 CDD:409353 0/3 (0%)
Ig strand C' 279..281 CDD:409353 1/1 (100%)
Ig strand E 291..296 CDD:409353 1/4 (25%)
Ig strand F 304..312 CDD:409353 4/7 (57%)
Ig strand G 315..326 CDD:409353 2/11 (18%)
Ig4_Contactin-2-like 330..414 CDD:143205 25/86 (29%)
Ig strand B 346..350 CDD:143205 0/3 (0%)
Ig strand C 359..363 CDD:143205 0/3 (0%)
Ig strand E 380..384 CDD:143205 0/3 (0%)
Ig strand F 394..399 CDD:143205 2/4 (50%)
Ig strand G 407..410 CDD:143205 1/2 (50%)
Ig5_Contactin 419..507 CDD:409358 26/87 (30%)
Ig strand B 438..442 CDD:409358 1/3 (33%)
Ig strand C 451..455 CDD:409358 0/3 (0%)
Ig strand E 473..477 CDD:409358 2/3 (67%)
Ig strand F 487..492 CDD:409358 4/4 (100%)
Ig strand G 500..503 CDD:409358 0/2 (0%)
Ig 509..605 CDD:416386 27/95 (28%)
Ig strand A 509..515 CDD:409353 2/5 (40%)
Ig strand A' 518..523 CDD:409353 0/4 (0%)
Ig strand B 526..534 CDD:409353 2/7 (29%)
Ig strand C 543..547 CDD:409353 0/3 (0%)
Ig strand D 568..571 CDD:409353 1/2 (50%)
Ig strand E 572..576 CDD:409353 1/3 (33%)
Ig strand F 585..592 CDD:409353 4/6 (67%)
Ig strand G 599..603 CDD:409353 0/3 (0%)
FN3 620..707 CDD:238020 28/91 (31%)
FN3 728..802 CDD:238020 19/79 (24%)
Cell attachment site. /evidence=ECO:0000255 796..798 1/1 (100%)
FN3 817..909 CDD:238020 26/93 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 895..921 7/25 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.