DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nrg and NFASC

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:XP_024310051.1 Gene:NFASC / 23114 HGNCID:29866 Length:1513 Species:Homo sapiens


Alignment Length:1369 Identity:414/1369 - (30%)
Similarity:614/1369 - (44%) Gaps:216/1369 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 AALLVALLCAGSA---------ESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQ 64
            ||.|:.||..|.|         :::..:||.||||.|...::       ...|| .:|||||.|.
Human   161 AAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIV-------DPRDN-ILIECEAKGN 217

  Fly    65 PEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPK----DEDRGHYQCFASNEFGTATSNSV 125
            |.|.:.|.:|.:.|: .|.|.|:..:...|||||....    :|..|.|||||.|:||||.||.:
Human   218 PAPSFHWTRNSRFFN-IAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFARNKFGTALSNRI 281

  Fly   126 YVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSI-NNSRMTLD 189
            .::.::...:..|....:...||.|..|:|..|.|.|||.:.||     ..|::.| .:.|::..
Human   282 RLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWM-----SSSMEPITQDKRVSQG 341

  Fly   190 PEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDV--KQMGVSASQNKHPPV---RQ 249
            ..|:|:||||..:|..:|  |:|:|...|....:..|...|.|  ......:|...||.:   |.
Human   342 HNGDLYFSNVMLQDMQTD--YSCNARFHFTHTIQQKNPFTLKVLTNHPYNDSSLRNHPDMYSARG 404

  Fly   250 YVSRRQS-----------LALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLV 303
            ...|..|           :.|||..:.|.||..|.|.|...|.|.|..:. ||:....::.|:|.
Human   405 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLP-SDKAKFENFNKALR 468

  Fly   304 IRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEP 368
            |...:.:|:|.|.|..||.:|:.: .:|.:.|.:.||:..||:....|..|:....|||.|.|:|
Human   469 ITNVSEEDSGEYFCLASNKMGSIR-HTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRANGNPKP 532

  Fly   369 KISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPP- 432
            .:.|:.||:|::.:.|||.|.|..:||...:........|.||.:|..||:..:.:::|...|| 
Human   533 TVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 597

  Fly   433 TISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLR---ASNWLTGGRYNVQANGDLEIQDVTFSD 494
            .:|.....:..:......:.|...|||.|.::|.:   .|| |.||.|:|..||.|||:.:...|
Human   598 MLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSN-LDGGNYHVYENGSLEIKMIRKED 661

  Fly   495 AGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKD 559
            .|.|||.|.|..|:.:....|.||:.|||.:.|::.....|.:....|...||.:|::.:.|.||
Human   662 QGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQLECRVKHDPSLKLTVSWLKD 726

  Fly   560 GQSIDFEAQPRFV----KTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIV--------- 611
            .       :|.::    |..|:||||....|.|.|.|||||.|.||:..|:|.|.|         
Human   727 D-------EPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLADQATPTN 784

  Fly   612 ------QDVPNAPKLTGITCQADKA-EIHWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVP 668
                  :..|:.|:...:|..|::: .:.|.....|.|||..|.:|| ...|.|..|. .:.|.|
Human   785 RLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITDYVVQFEEDQFQPGVWH-DHSKYP 848

  Fly   669 NTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVIS 733
            .:.:|.|:::||:.||.|||||.|::|:|.||..|:...|....|..||.:|.|:||..||:.|:
Human   849 GSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERYRTSGAPPESNPGDVKGEGTRKNNMEIT 913

  Fly   734 WTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGE 798
            ||||.......||..|.|.|:|.....||  ||:..| .:..|:...|.:|.|.|:|.|.||.|:
Human   914 WTPMNATSAFGPNLRYIVKWRRRETREAW--NNVTVW-GSRYVVGQTPVYVPYEIRVQAENDFGK 975

  Fly   799 SNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGE 863
             ....|.|:||||||.|..|||...:| :.:||:..:.|..|..::|:|..:.|:...|.|:...
Human   976 -GPEPESVIGYSGEDYPRAAPTEVKVR-VMNSTAISLQWNRVYSDTVQGQLREYRAYYWRESSLL 1038

  Fly   864 EGL------REIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQG 922
            :.|      ::....||....:|::..|.|.....::..|||.:||.|...:|.|||||||..:.
Human  1039 KNLWVSQKRQQASFPGDRLRGVVSRLFPYSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRR 1103

  Fly   923 LDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGER--REYDPHITDPRVTRMKMAGL 985
            ............|.|..|.:|||.:.||.:.|.....:.||::  ..:.|:.|...|.|     .
Human  1104 FRVRQPNLETINLEWDHPEHPNGIMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQR-----T 1163

  Fly   986 KPNSKYRISITATTKMGEGS-----------------------------------------EHYI 1009
            .|.|:||.:::|.|::|.|.                                         ....
Human  1164 DPVSRYRFTLSARTQVGSGEAVTEESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATT 1228

  Fly  1010 EKTTLKDAVNVAPAT------------------------PSFS-----WEQLPSDNGLAKFRI-- 1043
            |.||:.....|||.|                        |:.:     .|..|.:..:....:  
Human  1229 EATTVPIIPTVAPTTIATTTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLP 1293

  Fly  1044 --NWLPSTEGH---PGTHFFTMHRIKGETQWIRENEEK-------NSDYQEVGGLDPETAYEFRV 1096
              .|...|..|   |||.|.        .::|..|..|       .:...::..|.|...|..||
Human  1294 NSKWANITWKHNFGPGTDFV--------VEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRV 1350

  Fly  1097 VSVDGH--------FNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICI 1153
            .|.|..        |.|.:|.    ||.        ...:|..|||||:|.|:|.::::.:|:|.
Human  1351 YSRDNEGISSTVITFMTSTAY----TNN--------QADIATQGWFIGLMCAIALLVLILLIVCF 1403

  Fly  1154 IRRNRGGKYDVHD-RELANGRRDYPEEGGFHEYSQPLDNKS-AGRQSVSSANKPGVESDTDSMAE 1216
            |:|:|||||.|.: :::..|..|..||.|..:||.. |||. .|.|:.........||| ||:.:
Human  1404 IKRSRGGKYPVREKKDVPLGPEDPKEEDGSFDYSDE-DNKPLQGSQTSLDGTIKQQESD-DSLVD 1466

  Fly  1217 YGDG 1220
            ||:|
Human  1467 YGEG 1470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 33/76 (43%)
IG_like 57..127 CDD:214653 33/73 (45%)
Ig 135..214 CDD:299845 26/79 (33%)
IG_like 141..216 CDD:214653 26/75 (35%)
ig 251..332 CDD:278476 26/91 (29%)
I-set 339..427 CDD:254352 29/87 (33%)
Ig 354..427 CDD:299845 24/72 (33%)
I-set 432..517 CDD:254352 29/88 (33%)
Ig 446..517 CDD:299845 27/73 (37%)
I-set 522..611 CDD:254352 32/92 (35%)
ig 525..609 CDD:278476 29/87 (33%)
FN3 613..707 CDD:238020 34/95 (36%)
FN3 716..807 CDD:238020 35/90 (39%)
fn3 817..905 CDD:278470 24/93 (26%)
FN3 917..1004 CDD:238020 24/88 (27%)
FN3 1041..1111 CDD:238020 20/91 (22%)
Bravo_FIGEY 1155..>1221 CDD:290593 27/68 (40%)
NFASCXP_024310051.1 Ig_hNeurofascin_like 208..284 CDD:143283 33/76 (43%)
Ig 289..381 CDD:325142 29/98 (30%)
Ig3_L1-CAM_like 430..500 CDD:319298 22/71 (31%)
Ig 517..592 CDD:325142 24/74 (32%)
Ig 615..681 CDD:319273 26/66 (39%)
I-set 694..775 CDD:254352 30/87 (34%)
FN3 794..884 CDD:238020 33/90 (37%)
FN3 895..985 CDD:238020 36/93 (39%)
FN3 994..1093 CDD:238020 26/99 (26%)
FN3 1098..1189 CDD:238020 25/95 (26%)
fn3 1287..1359 CDD:306538 17/79 (22%)
Bravo_FIGEY 1405..1489 CDD:316405 27/68 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I9820
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 603 1.000 Inparanoid score I950
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47974
OrthoDB 1 1.010 - - D208655at33208
OrthoFinder 1 1.000 - - FOG0000777
OrthoInspector 1 1.000 - - otm40969
orthoMCL 1 0.900 - - OOG6_101169
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X532
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.740

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