DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Cntn2

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_796103.2	Gene:	Cntn2 / 21367	MGIID:	104518	Length:	1040	Species:	Mus musculus

Alignment Length:	1116	Identity:	305/1116 - (27%)
Similarity:	468/1116 - (41%)	Gaps:	159/1116 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AALLVALLCA-------GSAESKGNRP---PRITKQPAPGELLFKVAQQNKESDNPFIIECEADG 63
            |:||:.||..       |.:.|:|...   |...:||.  .|||    ..:.:::...:.|.|..
Mouse     9 ASLLLLLLATMALVSSPGWSFSQGTPATFGPVFEEQPV--GLLF----PEESAEDQVTLACRARA 67

  Fly    64 QPEPEYSWIKNGKKFDWQAYDNRMLRQPGR------GTLVITIP-KDEDRGHYQCFASNEFGTAT 121
            .|...|.|..||         ..|..:||.      |.|||..| |.:|.|.|||.|||..||..
Mouse    68 SPPATYRWKMNG---------TEMNLEPGSRHQLMGGNLVIMSPTKAQDAGVYQCLASNPVGTVV 123

  Fly   122 SNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQE-----SIDGSIKSI 181
            |....:|...|..|..|....::..||...||.|..|..:|..:..|::.|     ..||
Mouse   124 SKEAVLRFGFLQEFSKEERDPVKTHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDG----- 183

  Fly   182 NNSRMTLDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSAS------ 240
              ........|||:   :.|.:||....|:|.|||......|   .|.....|:.::|.
Mouse   184 --RHFVSQTTGNLY---IARTNASDLGNYSCLATSHLDFSTK---SVFSKFAQLNLAAEDPRLFA 240

  Fly   241 ---QNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSK-DGQ-RIQWSDRITQGHYGK 300
               :.:.||        ::.||.|:::.|.|...|.|:|:..|.| ||. ..||      |....
Mouse   241 PSIKARFPP--------ETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQW------GTAEP 291

  Fly   301 SLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGV 365
            :|.|...:|:|.|||.|:..|..|.......|: |.:.|.:.|......|.....:.:.|.|||.
Mouse   292 TLQIPSVSFEDEGTYECEAENSKGRDTVQGRII-VQAQPEWLKVISDTEADIGSNLRWGCAAAGK 355

  Fly   366 PEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAE 430
            |.|.:.|:.||:|:....   |..|....:|...|...|:|.|.|.|.|..|.:|....|.|||.
Mouse   356 PRPMVRWLRNGEPLASQN---RVEVLAGDLRFSKLNLEDSGMYQCVAENKHGTIYASAELAVQAL 417

  Fly   431 PPTISEAPA--AVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTF 492
            .|...:.|.  .:....|..::|.|:...:||..:.|.:.:..| ...|..|..:|.|.|::::.
Mouse   418 APDFRQNPVRRLIPAARGGEISIPCQPRAAPKATILWSKGTEILGNSTRVTVTLDGTLIIRNISR 482

  Fly   493 SDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWW 557
            ||.|||||:|:|..|:..:.|.|.|::.|:||..|.:.::..|.:.|.:|:.:||.|:::...|.
Mouse   483 SDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINVGDNLTLQCHASHDPTMDLTFTWT 547

  Fly   558 KDGQSIDFEA-----QPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNA 617
            .|...:||:.     :...||.....|||........|.|||:|:|.:|.|:..|.::|:..|..
Mouse   548 LDDFPVDFDKPGGHYRRASVKETIGDLTILNAQLRHGGTYTCMAQTVVDGASKEATVLVRGPPGP 612

  Fly   618 PKLTGITCQAD-KAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKV--------PNTDSS 673
            |....:....| ..::.|.:..||.|||..||:|   :.||.|  ..:::|        .|.:::
Mouse   613 PGGVVVRDIGDTTVQLSWSRGFDNHSPIAKYTLQ---ARTPPS--GKWKQVRTNPVNIEGNAETA 672

  Fly   674 FVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMP 738
            .|:.:.||.:|.|||.|.|.:|...||..|....|:..||...|..:.|.|..|..|.|:||||.
Mouse   673 QVLGLMPWMDYEFRVSASNILGTGEPSGPSSRIRTKEAVPSVAPSGLSGGGGAPGELTINWTPMS 737

  Fly   739 EIEHNAPNFHYYVSWKRDIPAAAWENNNI-------FDWRQNNIVIADQPTFVKYLIKVVAINDR 796
            ....|...|.|.:|::|. .:::|:...:       |.:..::|    .| :..:.:|:.:.|.|
Mouse   738 REYQNGDGFGYLLSFRRQ-GSSSWQTARVPGADTQYFVYSNDSI----HP-YTPFEVKIRSYNRR 796

  Fly   797 GESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENE 861
            |:...:...:| ||.|:.|..||.....:. :||:...::|.||.:: :.|...||:|:.|...:
Mouse   797 GDGPESLTAIV-YSAEEEPKVAPAKVWAKG-SSSSEMNVSWEPVLQD-MNGILLGYEIRYWKAGD 858

  Fly   862 GEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAY 926
            .|.....:...|...:|.||...|::|.:..:.|||....||.|...|..|.:..|....|..::
Mouse   859 KEAAADRVRTAGLDSSARVTGLYPNTKYHVTVRAYNRAGTGPASPSADAMTMKPPPRRPPGNISW 923

  Fly   927 PLGSSAFMLHWKK--PLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNS 989
            ...||:..|.|..  ||.....:||||:.|:                 .|.:.|.|    |...|
Mouse   924 TFSSSSLSLKWDPVVPLRNESTVTGYKMLYQ-----------------NDLQPTPM----LHLTS 967

  Fly   990 KYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSD-----NGLAKFRINWLPST 1049
            |..|.|.....:|..            .|.:....|  ..:.:|::     ||.....:......
Mouse   968 KNWIEIPVPEDIGHA------------LVQIRTTGP--GGDGIPAEVHIVRNGGTSMMVESSAVR 1018

  Fly  1050 EGHPGTHFFTM 1060
            ..|||..|..|
Mouse  1019 PAHPGPVFSCM 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	27/79 (34%)
		IG_like	57..127	CDD:214653	27/76 (36%)
		Ig	135..214	CDD:299845	21/83 (25%)
		IG_like	141..216	CDD:214653	20/79 (25%)
		ig	251..332	CDD:278476	25/82 (30%)
		I-set	339..427	CDD:254352	26/87 (30%)
		Ig	354..427	CDD:299845	23/72 (32%)
		I-set	432..517	CDD:254352	26/87 (30%)
		Ig	446..517	CDD:299845	24/71 (34%)
		I-set	522..611	CDD:254352	27/93 (29%)
		ig	525..609	CDD:278476	25/88 (28%)
		FN3	613..707	CDD:238020	30/102 (29%)
		FN3	716..807	CDD:238020	23/97 (24%)
		fn3	817..905	CDD:278470	24/87 (28%)
		FN3	917..1004	CDD:238020	22/88 (25%)
		FN3	1041..1111	CDD:238020	5/20 (25%)
		Bravo_FIGEY	1155..>1221	CDD:290593
Cntn2	NP_796103.2	Ig	38..131	CDD:386229	33/107 (31%)
		Ig2_Contactin-2-like	133..230	CDD:143204	28/109 (26%)
		Ig	241..326	CDD:386229	28/99 (28%)
		Ig4_Contactin-2-like	330..414	CDD:143205	25/86 (29%)
		Ig5_Contactin	435..507	CDD:319278	24/71 (34%)
		Ig	526..605	CDD:386229	23/78 (29%)
		FN3	620..707	CDD:238020	28/91 (31%)
		FN3	728..808	CDD:238020	20/86 (23%)
		Cell attachment site. /evidence=ECO:0000255	796..798		1/1 (100%)
		FN3	817..909	CDD:238020	26/93 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..922		7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810