DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Osmr

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_035149.2	Gene:	Osmr / 18414	MGIID:	1330819	Length:	971	Species:	Mus musculus

Alignment Length:	822	Identity:	164/822 - (19%)
Similarity:	278/822 - (33%)	Gaps:	263/822 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 VNSVPYFTKEPEI-------ATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPR----- 387
            ::.|.:..|..|:       |...|:..::|:...:.:......|:.|     .||...|
Mouse    36 IHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVEN-----YSTTVKREEAVR 95

  Fly   388 ------------------RTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTI 434
                              |.:.|:|   .:|.:...||:..         :|:|...|..||...
Mouse    96 WNWTSDIPLECVKHFIRIRALVDDT---KSLPQSSWGNWSS---------WKEVNAKVSVEPDKS 148

  Fly   435 SEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQA-------NGD-------- 484
            ...|......:|.|||| |.:.|.                ..|||..       :|:
Mouse   149 LIFPKDKVLEEGSNVTI-CLMYGQ----------------NVYNVSCKLQDEPIHGEQLDSHVSL 196

  Fly   485 LEIQDVTF-SDAG-KYTCYA----QNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCN 543
            |::.:|.| ||.| ...|.|    :..||.:     |.|   :::.:||:|.........|..|:
Mouse   197 LKLNNVVFLSDTGTNINCQATKGPKRIFGTV-----LFV---SKVLEEPKNVSCETRDFKTLDCS 253

  Fly   544 --EAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTND-NSLTIAKTMELDSG-----EYTCVARTRL 600
              ...|.||.     |:..:..::.....|.|..: ::...:.|.::..|     .:|..|..:|
Mouse   254 WEPGVDTTLT-----WRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQL 313

  Fly   601 DEATARA--NLIVQDVPNAP-----KLTGITCQADKAEIHWE--QQGDNRSPILHYTIQF----- 651
            .:.:...  ||..:..|.||     |:.|.|    ||.:.|:  ..|:|.:.:....:|:
Mouse   314 RKRSVNINFNLTHRVHPKAPQDVTLKIIGAT----KANMTWKVHSHGNNYTLLCQVKLQYGEVIH 374

  Fly   652 ----------NTSFTPASWDAAYEKVPNTDSSFVVQMS-----PWANYTFRVIAFNKIGASPPSA 701
                      |..|:....|..|:       :||...|     .|:::|      .|..::|.:|
Mouse   375 EHNVSVHMSANYLFSDLDPDTKYK-------AFVRCASANHFWKWSDWT------QKEFSTPETA 426

  Fly   702 HSDSCTTQPDVPFKNPDNVVGQGTEP------NNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAA 760
            .|.:......|..:|...:|....:|      |..:||:..:.|.|.......:|..|   .||.
Mouse   427 PSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVW---APAL 488

  Fly   761 AWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMR 825
            :           .|:.:..||    |.|::.|.|..|.|..:...:...||.:...:.    |::
Mouse   489 S-----------TNLSLDLQP----YKIRITANNSMGASPESLMVLSNDSGHEEVKEK----TIK 534

  Fly   826 QITSSTSGYMAWTPVSEESVRGHFKGYKIQ------------------------TWTENEGEEGL 866
            .|..:.:  ::|.|||     |...||.:.                        |.|.::.:.|:
Mouse   535 GIKDAFN--ISWEPVS-----GDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTITSDDFKPGV 592

  Fly   867 R---EIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGP---PSAVIDFDTPEGVPSPVQGLDA 925
            |   .|..:...|.|.:.:   ..:.|.:.||       |   |...|.:.||
Mouse   593 RYNFRIFERSVEHKARLVE---KQRGYTQELA-------PLVNPKVEIPYSTP------------ 635

  Fly   926 YPLGSSAFMLHWKKPLYPN----GKLTGYKIYY--EEVKESYVGERR---------EYDPHITDP 975
                 ::|:|.|  |.|.:    |.:.||.:|.  :|::.:...||.         :||  |...
Mouse   636 -----NSFVLRW--PDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYD--INGS 691

  Fly   976 RVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDA 1017
            ....:.:..|:|.|.|...:|..|..|.|......|.|..||
Mouse   692 ETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDA 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476
		I-set	339..427	CDD:254352	18/117 (15%)
		Ig	354..427	CDD:299845	14/95 (15%)
		I-set	432..517	CDD:254352	23/105 (22%)
		Ig	446..517	CDD:299845	22/91 (24%)
		I-set	522..611	CDD:254352	18/98 (18%)
		ig	525..609	CDD:278476	16/93 (17%)
		FN3	613..707	CDD:238020	25/120 (21%)
		FN3	716..807	CDD:238020	21/96 (22%)
		fn3	817..905	CDD:278470	20/117 (17%)
		FN3	917..1004	CDD:238020	22/101 (22%)
		FN3	1041..1111	CDD:238020
		Bravo_FIGEY	1155..>1221	CDD:290593
Osmr	NP_035149.2	LIFR_D2	30..137	CDD:375455	18/117 (15%)
		fn3	332..413	CDD:394996	18/91 (20%)
		WSXWS motif. /evidence=ECO:0000250	412..416		1/3 (33%)
		FN3	437..512	CDD:214495	21/92 (23%)
		FN3	622..730	CDD:238020	29/128 (23%)
		Box 1 motif. /evidence=ECO:0000250	767..775
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	949..971
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000