DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and egl-15

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	1041	Identity:	192/1041 - (18%)
Similarity:	347/1041 - (33%)	Gaps:	300/1041 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 GVSASQNKHPPVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQW----------- 289
            |:::...::.|..::|:..:.....|..::..|        ||..||....::|
Worm    23 GLTSHYRENIPRFKHVANERYEVFLGDEIKFDC--------QTAASKISAFVEWYRNDKLLKNDQ 79

  Fly   290 --SDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGN-AQSFSIILNVNSVPYF---------- 341
              .|:|.:.:....|.::..:..|.|.::|.|.|..|. :::|::.: ::...||
Worm    80 IDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHNAYGQISRNFTVEV-IDFCDYFLFPDIHHLNI 143

  Fly   342 -------------TKEPEIATAAEDEEV---------------------------------VFEC 360
                         .|..::..||...||                                 |.:.
Worm   144 PMECVCLWKYNKEAKRSDVNYAAVTGEVCSKYASRMINRARKPLPMIPCFGDHCKEFDTTPVSDF 208

  Fly   361 RAAGVPE--PKISWIHNGK-----PIEQSTPNPRRTVTDNTIRIINL-----VKGDTGNYGCNAT 413
            ...|.||  |.:..:...|     |:..|..:|..:.|:    .||.     .:.:..:|..:..
Worm   209 GLPGKPEDDPLVKRVVLKKDDVIVPVHDSEESPSESRTE----FINADEKENKEDEEEDYSVSQP 269

  Fly   414 NSLGYVYKD---VYLNVQAEPPTISEA-------------PAAVSTVDGRNVTIKCRVNGSPKPL 462
                 |..|   ..||:.||.|...::             ||      ||.:.:.||..|.|:|.
Worm   270 -----VAPDAGLTELNITAEEPPYFKSNDNIVLFNETHALPA------GRTLKLNCRAKGYPEPQ 323

  Fly   463 VKW------LRASNWLTGGRYNVQAN-GDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEH 520
            :.|      |:.|:..:|| |..:.| ..||::|...:|:|::.|.|.||.|..:....:::.
Worm   324 IIWYKNGKMLKKSSARSGG-YEFKFNRWSLEVEDAVVADSGEFHCEALNKVGSAKKYFHVIIV-- 385

  Fly   521 TRITQEP-------QNYEVAAGQSATFRCNEAHDDTLEIEIDWWK---------------DGQSI 563
            .|:.:.|       .|..|....:|||.|....|  |...|.|.:               :....
Worm   386 NRMRRPPIIVPNILANQSVNINDTATFHCKVVSD--LLPHIIWVRINKINGSYSYYNNSAEEYMF 448

  Fly   564 DFEAQPRFVKT------NDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTG 622
            ::.....|.|.      ::::|||......|.|.|.|::...|..:.|.|.|.|.:......|||
Worm   449 NYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGIYACLSGNSLGMSMANATLTVNEFMAIHLLTG 513

  Fly   623 ITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNTDSSFVV-----QMSPWA 682
            ...:.|:    |.......:.||.:.:...|.|               ...|:|     ....:.
Worm   514 DEPKIDR----WTTSDYIFTTILLFLLLAATLF---------------GILFMVCKQTLHKKGFM 559

  Fly   683 NYTFRVIAFNK---IGASPPSAHSDSCTTQP--------DVPFKNPDNVVGQGTEPN--NLVIS- 733
            :.|..::|..|   :...|.:..:::...:|        :.|....:....|....|  |.|:|
Worm   560 DDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQIIETPITKKEAARKQRKRMNSENTVLSE 624

  Fly   734 ----WTPMPEIEHNAPNFHYYVS-------WKRDIPAAAWENNNI--------FDWRQNNIV--I 777
                ..|:.|:|.:..:..:.:.       ||......  |||.|        ....:..::  :
Worm   625 YEVDSDPVWEVERSKLSLVHMLGEGAFGEVWKATYKET--ENNEIAVAVKKLKMSAHEKELIDLV 687

  Fly   778 ADQPTFVKYLIKVVAINDR-----------GESNVAAE-----EVVGYSGEDRPLDAPTNFTMRQ 826
            ::..||     ||:..::.           |...|..|     .:..:....||.:.....:.::
Worm   688 SEMETF-----KVIGEHENVLRLIGCCTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQE 747

  Fly   827 ITSSTSGYMAWTPVSEESVRGHFKGYKIQ-TWTENEGEEGL---REIH--------VKGDTHNAL 879
            :|.......|......|.:....:.:.:| .|...:|...|   :.||        :.||.|...
Worm   748 LTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVAQGMNFLASKKIIHRDLAARNVLVGDGHVLK 812

  Fly   880 VTQF----KPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGL--DAYPLGSSAFMLHWK 938
            ::.|    .....:|     |..|.||  ...|.:...|.:.|.|..:  |.:..|    :|.|:
Worm   813 ISDFGLSRDVHCNDY-----YRKRGNG--RLPIKWMALEALDSNVYTVESDVWSYG----VLLWE 866

  Fly   939 ------KPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRIS--- 994
                  .| ||.   ......|..:||.|    |...||:....|..:..:..:...:.|.|
Worm   867 IMTLGGTP-YPT---IAMPELYANLKEGY----RMEPPHLCPQEVYHLMCSCWREKLEERPSFKT 923

  Fly   995 --------ITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEG 1051
                    :|.|.:..|||:.:.::...:.:....|.:|..|:::......|:. .:| |||...
Worm   924 IVDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSA-PVN-LPSEPQ 986

  Fly  1052 H 1052
            |
Worm   987 H 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	18/94 (19%)
		I-set	339..427	CDD:254352	23/158 (15%)
		Ig	354..427	CDD:299845	18/120 (15%)
		I-set	432..517	CDD:254352	27/104 (26%)
		Ig	446..517	CDD:299845	24/77 (31%)
		I-set	522..611	CDD:254352	25/116 (22%)
		ig	525..609	CDD:278476	23/111 (21%)
		FN3	613..707	CDD:238020	15/101 (15%)
		FN3	716..807	CDD:238020	21/130 (16%)
		fn3	817..905	CDD:278470	18/103 (17%)
		FN3	917..1004	CDD:238020	21/105 (20%)
		FN3	1041..1111	CDD:238020	5/12 (42%)
		Bravo_FIGEY	1155..>1221	CDD:290593
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	17/92 (18%)
		Ig	47..126	CDD:299845	17/86 (20%)
		Ig	302..382	CDD:299845	26/86 (30%)
		IG_like	306..384	CDD:214653	25/84 (30%)
		IG_like	401..502	CDD:214653	23/102 (23%)
		Ig3_FGFR	407..503	CDD:143175	21/97 (22%)
		PKc_like	627..933	CDD:304357	57/331 (17%)
		Pkinase_Tyr	640..928	CDD:285015	54/313 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000