DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and sax-7

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001033396.1	Gene:	sax-7 / 177602	WormBaseID:	WBGene00004732	Length:	1331	Species:	Caenorhabditis elegans

Alignment Length:	1399	Identity:	403/1399 - (28%)
Similarity:	632/1399 - (45%)	Gaps:	203/1399 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QSTILAALLVALLCAGSAE-SKGNRPPRITKQPAPGELLFKVAQQNKESDN---------PFIIE 58
            :|.|...||...:.:||.: |....||:.........:.|||.:.....::         ...|.
Worm     2 RSFIFLLLLTGHISSGSIDWSAIETPPQFVHDKNADTVYFKVEKSGMSDESAKNTPGNLLEQTIH 66

  Fly    59 CEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKDEDRGHYQCFASNEFGTATSN 123
            |.|:|.|.|.|.|.|:||.|....:..:::::||.|:||.:...:.|.|.|||.|.|..|||...
Worm    67 CYANGNPRPSYRWKKDGKTFLPSMFPEKVVQKPGEGSLVFSRLDESDAGLYQCEAENSNGTAVDR 131

  Fly   124 SVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTL 188
            .|.|::..:..||....:.:....|:|:...|:.|...|...|.|::.....|..::|::|.::.
Worm   132 PVRVQETWIRHFKTAEPEVVVVEVGDPYQRNCSPPASNPYARVYWILMGKEPGHFETISSSHISS 196

  Fly   189 DPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKH------PPV 247
            :.:|.|:|..|...|..||.||.|:|.::...:||.||       |..:..:.||.      ||.
Worm   197 NEQGTLFFHYVNETDFKSDRYYTCTAENIELKDYKFGN-------QFSLQITNNKRRSLQQMPPT 254

  Fly   248 RQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQG----HYGKSLVIRQTN 308
            .|||::...:||:|.:.:|.|.:.|.|.|:..|..:|:.|. .|....|    .|||:||...|.
Worm   255 EQYVNQSSPIALQGNQHKLHCFFSGYPAPKPRWFHNGREIS-EDSDAAGFRFESYGKTLVFNVTQ 318

  Fly   309 FDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIAT-AAEDEEVVFECRAAGVPEPKISW 372
             |.||.|.|..:......::|:::  |.:.||:...|...| .:|.|:|:|:|...|.|.||:::
Worm   319 -DKAGKYDCRFATQQDIDRTFNVV--VEAAPYWPLGPPPNTNTSEGEKVIFDCTTYGKPTPKVTF 380

  Fly   373 IHNGKPIEQSTPNPRRTVTDNTIRIINLV-----KGDTGNYGCNATNSLGYVYKDVYLNVQAEPP 432
            ..||..|| |..:.|..:....:.|.::.     |||...|.|.:.|..|:::.:.|||:.|..|
Worm   381 YKNGVEIE-SQKDDRYLIEGTRLTIFDVKKGTYGKGDNAVYQCKSENKHGWLWTNFYLNLLAFKP 444

  Fly   433 TISEAPA--AVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYN-VQAN----GDLEIQDV 490
            .:...|.  .|..|.|:.||::|:...||...|||  .:..::|.:.| :.|:    |.|...:|
Worm   445 QLLIDPGKEEVEAVAGKKVTLECKFFASPNAAVKW--EAPMISGSKGNQIPADAYGVGKLVFSEV 507

  Fly   491 TFSDAGKYTCYAQNKFGEIQADG--SLVVKEHTRITQEPQNYEV-AAGQSATFRCNEAHDDTLEI 552
            |.::.|:|.|...||:|  ||.|  :|.|::.|.:...|:..|| .||:.....|:...|:.||:
Worm   508 TAAEEGEYECIGTNKYG--QATGLITLKVRKPTIVQPFPRVEEVRMAGEEMRLACDATADNQLEV 570

  Fly   553 EIDWWKDGQSI--DFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVP 615
            :.:|..||:|:  |..:...:...:|:||.|:...:.|:.:|.||..|:||:......:..:|||
Worm   571 KYEWLVDGKSLPEDRISSGHYKIDDDHSLVISNPTQDDTAKYKCVVSTKLDQVEKEIKIQFKDVP 635

  Fly   616 NAPKLTGI-TCQADKAEI-------HWEQQGDNRSPILHYTIQFN-TSFTPAS-W------DAAY 664
            .|.....: ||  ||..:       |:|.. ...:||..:.:|:. .|.|..| |      .||:
Worm   636 VAVHSAWVQTC--DKNSLTAFIKFEHYESI-HTIAPIKEFWVQYQIDSETEGSQWRTHPVPSAAH 697

  Fly   665 --EKVPN----TDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQ 723
              :|:.|    |.....|.:.|:..|.|||||.|.:|.|......|.|.|....|.||||.|..:
Worm   698 PNDKIDNNLRHTTGDATVSLQPFGKYVFRVIARNSVGDSAARLAKDQCETPAKQPDKNPDEVAAK 762

  Fly   724 GTEPNNLVISWTPMPEIEHNAPNFHYYVSWK-RDIPAAAWENNNIFDWRQNNI--VIADQPT--- 782
            ||.|.|:::.|.||...|.|..:|||.|.:: :|      |:..:.||::..:  ..||:.|
Worm   763 GTSPENIIVQWKPMSREEWNGADFHYVVKYRPKD------EDQRVGDWKEVAVEDPFADRVTVNL 821

  Fly   783 --------FVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTP 839
                    |..|.::|.|:|..|.:||..|.|.|.:||..|...|:...:.: .|.|:..:||..
Worm   822 DDEKDVKPFQPYEVQVQAVNSEGRTNVVPETVEGRTGEGVPSSIPSGLRVLE-KSGTTVTLAWNG 885

  Fly   840 VSEESVRGHFKGYKIQTWT------------ENEGEE----------------GLREIHVKG-DT 875
            |..::..|:|.||||..|.            ::|.:|                |:|:..|.| ..
Worm   886 VDPQTANGNFTGYKITYWVDEADQDSDDSSEDDEDDEKRKFRWKRSIRVKRQSGIRKTVVFGPSA 950

  Fly   876 HNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGS------SAFM 934
            ....:|..||.:.|:|.|...||...|..|..|||.|.|||||||:.|.|||:.|      ...:
Worm   951 TQGTLTDLKPATLNHAYIQVTNGAHEGSASDTIDFQTDEGVPSPVRSLRAYPMNSKVGGEKGVVV 1015

  Fly   935 LHWKKPLYPNGKLTGYKIYYEEVKESYVGE----RREYDPHITDPRVTRMKMAGLKPNSKYRISI 995
            |.||||...||||..|::.|.:.:...:.|    |::.|....:.|:|     ||:..:.||..:
Worm  1016 LVWKKPRQTNGKLARYEVEYCKTQNGKLVEKSCPRKQIDADSKEIRIT-----GLENETPYRFIL 1075

  Fly   996 TATTKMGEGSEHYIEKTTLKD--AVNVAPATPSFSWEQLPSDNGLAK--FRINWLPS-----TEG 1051
            .|.|..|||..:..:.|||.:  |..|.|..||.      .:|.:..  |.:::.|:     :..
Worm  1076 RAHTSAGEGDPNSSDATTLPETTAAGVDPGVPSL------VENAIGDKYFNVSFRPAKYDDESRA 1134

  Fly  1052 HPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEID--- 1113
            ..|..:...::.:...:|.......:.....|.||.|.|.|:.||           |..::|
Worm  1135 PVGNTYEVQYKPQDADEWETVKPADDGLTVHVDGLSPGTKYDVRV-----------AALQVDPEG 1188

  Fly  1114 ---TNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIII----CIIRRNRGGKYDVHDRELAN 1171
               |.|:.|...:.....::....:.:::.|..|::|.:||    |::.|.||..|.|..||...
Worm  1189 GETTKTLSGISKITTTGTSSRERNVYLLILLLLILLLLLIICCICCVVCRQRGQNYPVSQREREQ 1253

  Fly  1172 GRRDYPEEGGFHEYSQPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTAVATAAARAAAAAR 1236
            ||....   |..:|....|.|    :|::.:.   .||:|||||:|||.|..|.|......|.:
Worm  1254 GREPIL---GKPDYKTDDDEK----RSLTGSK---AESETDSMAQYGDTDPGVFTEDGSFIAVS- 1307

  Fly  1237 SKLTSLPTSTQQQQQQQQQQQQQQEQPQSTSAST 1270
                        .|...|:.....|:|:..|.||
Worm  1308 ------------GQYVPQKSLMPAERPEKGSTST 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	28/72 (39%)
		IG_like	57..127	CDD:214653	28/69 (41%)
		Ig	135..214	CDD:299845	22/78 (28%)
		IG_like	141..216	CDD:214653	21/74 (28%)
		ig	251..332	CDD:278476	26/84 (31%)
		I-set	339..427	CDD:254352	29/93 (31%)
		Ig	354..427	CDD:299845	24/77 (31%)
		I-set	432..517	CDD:254352	30/93 (32%)
		Ig	446..517	CDD:299845	26/77 (34%)
		I-set	522..611	CDD:254352	25/91 (27%)
		ig	525..609	CDD:278476	25/86 (29%)
		FN3	613..707	CDD:238020	34/115 (30%)
		FN3	716..807	CDD:238020	33/104 (32%)
		fn3	817..905	CDD:278470	28/116 (24%)
		FN3	917..1004	CDD:238020	32/96 (33%)
		FN3	1041..1111	CDD:238020	13/74 (18%)
		Bravo_FIGEY	1155..>1221	CDD:290593	24/65 (37%)
sax-7	NP_001033396.1	Ig	64..128	CDD:319273	25/63 (40%)
		Ig	156..222	CDD:386229	20/65 (31%)
		Ig_3	258..327	CDD:372822	24/70 (34%)
		Ig	350..429	CDD:386229	24/79 (30%)
		IG	453..534	CDD:214652	28/84 (33%)
		Ig	537..630	CDD:386229	26/92 (28%)
		FN3	<667..737	CDD:238020	22/69 (32%)
		FN3	755..857	CDD:238020	35/107 (33%)
		fn3	866..977	CDD:365830	27/111 (24%)
		FN3	992..1093	CDD:238020	34/105 (32%)
		FN3	1104..1181	CDD:238020	16/93 (17%)
		Bravo_FIGEY	1238..1310	CDD:372781	28/94 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I7438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.830