DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Lifr

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_001345522.1	Gene:	Lifr / 16880	MGIID:	96788	Length:	1092	Species:	Mus musculus

Alignment Length:	1014	Identity:	197/1014 - (19%)
Similarity:	326/1014 - (32%)	Gaps:	317/1014 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 WSKDGQRI------QWSDRITQGHYGK--SLVIRQTNFDDAGT-----YTCDVSNGVGNAQSFSI 331
            |:..|..:      .|..::.|....:  :||:..|......|     :|.|:..... ..|.||
Mouse   152 WNDRGSALPHPSNATWEIKVLQNPRTEPVALVLLNTMLSGKDTVQHWNWTSDLPLQCA-THSVSI 215

  Fly   332 ILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHN--------------GKPIEQS 382
            ..:::| |:|:...|.:..:              |...||||.|              |..:...
Mouse   216 RWHIDS-PHFSGYKEWSDWS--------------PLKNISWIRNTETNVFPQDKVVLAGSNMTIC 265

  Fly   383 TPNPRRTVT---DNTIR-------------IINL-VKGDTGNYGCNATNSLGYVYKDVYLNV--Q 428
            ..:|.:.::   .||:|             |:|: |..::|      ||.:.....|||..|  .
Mouse   266 CMSPTKVLSGQIGNTLRPLIHLYGQTVAIHILNIPVSENSG------TNIIFITDDDVYGTVVFA 324

  Fly   429 AEPPTISEA----------------PAAVSTVDG-RNVTIKCRVNGSPKPLVKWLRASNWLTGGR 476
            ..||.:.:.                |..::.:.| ||.......:.|.|..|  ......||...
Mouse   325 GYPPDVPQKLSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAV--FHRIEGLTNET 387

  Fly   477 Y--NVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRIT-QEPQNYEVAAGQSA 538
            |  .||.:...||.:        :|...:|..|  ||..::|:....|:. .:|.:.:|....|.
Mouse   388 YRLGVQMHPGQEIHN--------FTLTGRNPLG--QAQSAVVINVTERVAPHDPTSLKVKDINST 442

  Fly   539 TFRCNEAHDDTLEIEIDWWKDGQ--SIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLD 601
            .            :...|:..|.  .|:...|....|.|........|:.........||..:|:
Mouse   443 V------------VTFSWYLPGNFTKINLLCQIEICKANSKKEVRNATIRGAEDSTYHVAVDKLN 495

  Fly   602 EATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWD----- 661
            ..||..             ..:.| :.|....|.:..|.:.   |.|.:...|..|.:|.
Mouse   496 PYTAYT-------------FRVRC-SSKTFWKWSRWSDEKR---HLTTEATPSKGPDTWREWSSD 543

  Fly   662 -----AAYEKVP-----------------NTDSSFV-----------VQMSPWANYTFRVIAFNK 693
                 ..::.:|                 |.::..|           :|:|. .:|...|:|.|.
Mouse   544 GKNLIVYWKPLPINEANGKILSYNVSCSLNEETQSVLEIFDPQHRAEIQLSK-NDYIISVVARNS 607

  Fly   694 IGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNF--HYYVSW--- 753
            .|:||||..:.......|:   ..:..||.|   |.:.::|      .|: ||.  .|.:.|
Mouse   608 AGSSPPSKIASMEIPNDDI---TVEQAVGLG---NRIFLTW------RHD-PNMTCDYVIKWCNS 659

  Fly   754 KRDIPAAAWENNNIFDWRQ------NNIVIADQ-PTFVKYLIKVVAINDRGESNVAAEEVVGYSG 811
            .|..|.       :.|||:      ..::.:|| ...|:|...:....::|..  ....::||..
Mouse   660 SRSEPC-------LLDWRKVPSNSTETVIESDQFQPGVRYNFYLYGCTNQGYQ--LLRSIIGYVE 715

  Fly   812 EDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTH 876
            |..|:.|| |||:.. ||:.|..:.|..:..|.:||..:||..              ...||:..
Mouse   716 ELAPIVAP-NFTVED-TSADSILVKWDDIPVEELRGFLRGYLF--------------YFQKGERD 764

  Fly   877 NALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPL 941
            .......:|   :::.|...|         :.|........:.:||..:|.|...|
Mouse   765 TPKTRSLEP---HHSDIKLKN---------ITDISQKTLRIADLQGKTSYHLVLRA--------- 808

  Fly   942 YPNGKLTGYKIYYEEVKESYVG------------------------ERREYDPHITDPRVTRMKM 982
            |.:|.|...|..:...||:.||                        .:||:......|.:
Mouse   809 YTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDI----- 868

  Fly   983 AGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLP 1047
                ||.:...::.....:.|||      ..|| .:.:.|.||: :.|.|.|.:.:.|.....:.
Mouse   869 ----PNPENCKALQFQKSVCEGS------NALK-TLEMNPCTPN-NVEVLESRSIVPKIEDTEII 921

  Fly  1048 S---------TEGHPGTHFFTMHRIKGETQWIRENEEKNSDYQEVGG------LDPETAYEFRVV 1097
            |         :|..|..|....:     ...|.|.|..|....||||      :|.::.|:.:..
Mouse   922 SPVAERPGERSEVDPENHVVVSY-----CPPIIEEEITNPAADEVGGASQVVYIDVQSMYQPQAK 981

  Fly  1098 SVDGHFNTESATQEIDTNTVEG-------PIMVANETVA 1129
            :.:        .|::|...|.|       ||..|.|..|
Mouse   982 AEE--------EQDVDPVVVAGYKPQMRLPISPAVEDTA 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	12/64 (19%)
		I-set	339..427	CDD:254352	23/118 (19%)
		Ig	354..427	CDD:299845	20/103 (19%)
		I-set	432..517	CDD:254352	20/103 (19%)
		Ig	446..517	CDD:299845	18/73 (25%)
		I-set	522..611	CDD:254352	16/91 (18%)
		ig	525..609	CDD:278476	15/85 (18%)
		FN3	613..707	CDD:238020	23/131 (18%)
		FN3	716..807	CDD:238020	20/102 (20%)
		fn3	817..905	CDD:278470	19/87 (22%)
		FN3	917..1004	CDD:238020	18/110 (16%)
		FN3	1041..1111	CDD:238020	14/84 (17%)
		Bravo_FIGEY	1155..>1221	CDD:290593
Lifr	NP_001345522.1	LIFR_N	50..124	CDD:375634
		LIFR_D2	126..239	CDD:375455	18/102 (18%)
		FN3	428..525	CDD:238020	20/125 (16%)
		WSXWS motif	514..518		1/3 (33%)
		FN3	547..613	CDD:389787	11/66 (17%)
		FN3	724..816	CDD:238020	26/127 (20%)
		Box 1 motif	864..872		3/16 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1009..1092		2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000