DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and L1cam

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_032504.3	Gene:	L1cam / 16728	MGIID:	96721	Length:	1259	Species:	Mus musculus

Alignment Length:	1279	Identity:	371/1279 - (29%)
Similarity:	596/1279 - (46%)	Gaps:	151/1279 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLCAGSA------ESKGN---RPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYS 70
            |||:...      |.||:   .||.||:|.....::|..        :...::|||.|:|:.|:.
Mouse    12 LLCSPCLLIQIPDEYKGHHVLEPPVITEQSPRRLVVFPT--------DDISLKCEARGRPQVEFR 68

  Fly    71 WIKNGKKFDWQAYDNRMLRQ-PGRGTLVITIPKDED-----RGHYQCFASNEFGTATSNSVYVRK 129
            |.|:|..|..:.....::.: |..|:  .||..:..     :|.|:|:|||:.|||.|:.:.:..
Mouse    69 WTKDGIHFKPKEELGVVVHEAPYSGS--FTIEGNNSFAQRFQGIYRCYASNKLGTAMSHEIQLVA 131

  Fly   130 AELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSINNSRMTLDPEGNL 194
            .....:..|..|.:|..|||..:|.|..|.......:.||..:.:  .||  .:.|:::...|:|
Mouse   132 EGAPKWPKETVKPVEVEEGESVVLPCNPPPSAAPLRIYWMNSKIL--HIK--QDERVSMGQNGDL 192

  Fly   195 WFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHP----PVRQYVSRRQ 255
            :|:||...|..||  |.|:|.  |.....|..|..:|::....::..::.|    |..   |..:
Mouse   193 YFANVLTSDNHSD--YICNAH--FPGTRTIIQKEPIDLRVKPTNSMIDRKPRLLFPTN---SSSR 250

  Fly   256 SLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVS 320
            .:||:|:.:.|.||..|.|.|...|......:. :||:...::.|:|.:.....:|.|.|||...
Mouse   251 LVALQGQSLILECIAEGFPTPTIKWLHPSDPMP-TDRVIYQNHNKTLQLLNVGEEDDGEYTCLAE 314

  Fly   321 NGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPN 385
            |.:|:|: .:..:.|.:.||:.::|:.......|....:|:..|.|:|:|:|..||..:|....:
Mouse   315 NSLGSAR-HAYYVTVEAAPYWLQKPQSHLYGPGETARLDCQVQGRPQPEITWRINGMSMETVNKD 378

  Fly   386 PRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAPAAVST------- 443
            .:..:...::.:.|:...||....|.|.|..|.:..:.|:.|       .:.||.:.|
Mouse   379 QKYRIEQGSLILSNVQPSDTMVTQCEARNQHGLLLANAYIYV-------VQLPARILTKDNQTYM 436

  Fly   444 -VDGRNVTIKCRVNGSPKPLVKWL--RASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNK 505
             |:|....:.|:..|:|.|.|:||  ..:..|...|:...|||.|.|:|:..:|.|:|.|.|.|.
Mouse   437 AVEGSTAYLLCKAFGAPVPSVQWLDEEGTTVLQDERFFPYANGTLSIRDLQANDTGRYFCQAAND 501

  Fly   506 FGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPR 570
            ...:....:|.|||.|:|||.|::.....|...||.|..:.|.:|:..|.|..||:.:.......
Mouse   502 QNNVTILANLQVKEATQITQGPRSAIEKKGARVTFTCQASFDPSLQASITWRGDGRDLQERGDSD 566

  Fly   571 FVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPN-APKLTGITCQADK----- 629
            .....|..|.|......|.|.|:|||.|.|||..:||.|:|...|. .|.|.    .:|:
Mouse   567 KYFIEDGKLVIQSLDYSDQGNYSCVASTELDEVESRAQLLVVGSPGPVPHLE----LSDRHLLKQ 627

  Fly   630 AEIH--WEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAF 691
            :::|  |....|:.|||..|.|:| :....|..| .:..|||...:|..:::||:.:|||||.|.
Mouse   628 SQVHLSWSPAEDHNSPIEKYDIEFEDKEMAPEKW-FSLGKVPGNQTSTTLKLSPYVHYTFRVTAI 691

  Fly   692 NKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRD 756
            ||.|...||..|::..|....|.|||.:|.|:|.|.||:||:|.|:..::.|||...|.|.|:..
Mouse   692 NKYGPGEPSPVSETVVTPEAAPEKNPVDVRGEGNETNNMVITWKPLRWMDWNAPQIQYRVQWRPQ 756

  Fly   757 IPAAAWENNNIFDWRQNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTN 821
            .....|....:.|   ..:|:::..|||.|.|||.|:|::|: ....:..:||||||.|..:|
Mouse   757 GKQETWREQTVSD---PFLVVSNTSTFVPYEIKVQAVNNQGK-GPEPQVTIGYSGEDYPQVSP-- 815

  Fly   822 FTMRQIT--SSTSGYMAWTPVSEESVRGHFKGYKIQTWTE-NEGEEGLREIH-----VKGDTHNA 878
             .:..||  :|::..:.|.||....|:||.|||.:..|.: ::.:...|.||     |..:|.:|
Mouse   816 -ELEDITIFNSSTVLVRWRPVDLAQVKGHLKGYNVTYWWKGSQRKHSKRHIHKSHIVVPANTTSA 879

  Fly   879 LVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYP 943
            :::..:|.|..:..:.|:|||..||.|. ..|.||||||...:.|.......::.:|||:.||..
Mouse   880 ILSGLRPYSSYHVEVQAFNGRGLGPASE-WTFSTPEGVPGHPEALHLECQSDTSLLLHWQPPLSH 943

  Fly   944 NGKLTGYKIYYEEVKESYVGERRE-YDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEH 1007
            ||.||||.:.|..|:    ||.:| ...:::||.:....:..|.|:.:||..:.|||:.|.|...
Mouse   944 NGVLTGYLLSYHPVE----GESKEQLFFNLSDPELRTHNLTNLNPDLQYRFQLQATTQQGPGEAI 1004

  Fly  1008 YIEKTTL-----KDAVNV-APATPSFSWEQLPSDNGLAKFRINWL----------PSTEGHPGTH 1056
            ..|..|:     .|..|: |.|..::|........|...||.:.|          |..:..|.
Mouse  1005 VREGGTMALFGKPDFGNISATAGENYSVVSWVPRKGQCNFRFHILFKALPEGKVSPDHQPQPQ-- 1067

  Fly  1057 FFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNT-VEGP 1120
             :..:.....|||               .|.|:|.||..::      ..:.....:|..| ..||
Mouse  1068 -YVSYNQSSYTQW---------------NLQPDTKYEIHLI------KEKVLLHHLDVKTNGTGP 1110

  Fly  1121 IMVANE-TVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRE---LANGRRDYPEEGG 1181
            :.|:.. :.|:.||||..:.|:..::::.:|:|.|:|::||||.|.|:|   :.:..|...:| .
Mouse  1111 VRVSTTGSFASEGWFIAFVSAIILLLLILLILCFIKRSKGGKYSVKDKEDTQVDSEARPMKDE-T 1174

  Fly  1182 FHEY-SQPLDNKSAGRQSVSSANKPGVESD------TDSMAEYG 1218
            |.|| |...||:    :....:::|.:..|      .||:|:||
Mouse  1175 FGEYRSLESDNE----EKAFGSSQPSLNGDIKPLGSDDSLADYG 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	24/78 (31%)
		IG_like	57..127	CDD:214653	24/75 (32%)
		Ig	135..214	CDD:299845	24/78 (31%)
		IG_like	141..216	CDD:214653	24/74 (32%)
		ig	251..332	CDD:278476	23/80 (29%)
		I-set	339..427	CDD:254352	21/87 (24%)
		Ig	354..427	CDD:299845	18/72 (25%)
		I-set	432..517	CDD:254352	27/94 (29%)
		Ig	446..517	CDD:299845	23/72 (32%)
		I-set	522..611	CDD:254352	30/88 (34%)
		ig	525..609	CDD:278476	27/83 (33%)
		FN3	613..707	CDD:238020	33/102 (32%)
		FN3	716..807	CDD:238020	31/90 (34%)
		fn3	817..905	CDD:278470	28/95 (29%)
		FN3	917..1004	CDD:238020	28/87 (32%)
		FN3	1041..1111	CDD:238020	13/79 (16%)
		Bravo_FIGEY	1155..>1221	CDD:290593	23/74 (31%)
L1cam	NP_032504.3	Ig_L1-CAM_like	53..130	CDD:319299	24/78 (31%)
		Ig	133..227	CDD:386229	29/101 (29%)
		Ig3_L1-CAM	259..329	CDD:143284	19/71 (27%)
		Ig	346..421	CDD:386229	19/81 (23%)
		IG_like	433..513	CDD:214653	24/79 (30%)
		Ig	518..607	CDD:386229	30/88 (34%)
		Cell attachment site. /evidence=ECO:0000255	553..555		0/1 (0%)
		Cell attachment site. /evidence=ECO:0000255	562..564		0/1 (0%)
		FN3	611..708	CDD:238020	33/101 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..724		10/26 (38%)
		fn3	717..798	CDD:365830	30/84 (36%)
		fn3	824..904	CDD:365830	23/79 (29%)
		fn3	920..1002	CDD:365830	27/85 (32%)
		Bravo_FIGEY	1146..1231	CDD:372781	23/74 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1182..1209		4/30 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1228..1259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9875
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I994
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm43039
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740