DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrg and Il12rb2

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_032380.1	Gene:	Il12rb2 / 16162	MGIID:	1270861	Length:	874	Species:	Mus musculus

Alignment Length:	868	Identity:	174/868 - (20%)
Similarity:	281/868 - (32%)	Gaps:	329/868 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 NGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGC--NATNSLGYVYKDVYLNVQAEPPT---- 433
            :||.:...|.:      .:|.::.||..|.| .:.|  |.:||            |.:||.
Mouse    83 HGKKVHDHTGH------SSTFQVTNLSLGMT-LFVCKLNCSNS------------QKKPPVPVCG 128

  Fly   434 --IS-----EAPAAVSTV-DGRNVTIKCRVNGSPKPLVKWLRASNWLTGGRYNVQANG--DLEIQ 488
              ||     |.|..:|.| :|.|.|:.|..|...   |.:|:.:       |.:|.:|  :|..|
Mouse   129 VEISVGVAPEPPQNISCVQEGENGTVACSWNSGK---VTYLKTN-------YTLQLSGPNNLTCQ 183

  Fly   489 DVTFSDAGKYTC------------YAQNKF-------GEIQADGSLVVKEHT------------- 521
            ...||| .:..|            .|:::|       .::....||   .||
Mouse   184 KQCFSD-NRQNCNRLDLGINLSPDLAESRFIVRVTAINDLGNSSSL---PHTFTFLDIVIPLPPW 244

  Fly   522 --RITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNS------ 578
              ||     |:..|:|...|              :.|..:||.:  ..|.|:...|..|
Mouse   245 DIRI-----NFLNASGSRGT--------------LQWEDEGQVV--LNQLRYQPLNSTSWNMVNA 288

  Fly   579 -------------------LTIAKTMELDSGEYTCVA---RTRLDEATARANLIV----QDVPNA 617
                               ..|:..:.|..|.::..:   |||..|......|.:    ||:
Mouse   289 TNAKGKYDLRDLRPFTEYEFQISSKLHLSGGSWSNWSESLRTRTPEEEPVGILDIWYMKQDI--- 350

  Fly   618 PKLTGITCQADKAEI--HWE--QQGDNRSPILHY-----------TIQFNTSFTPASWDAAYEKV 667
                    ..|:.:|  .|:  ...:.|..||||           |:|..|..|  ||...   :
Mouse   351 --------DYDRQQISLFWKSLNPSEARGKILHYQVTLQEVTKKTTLQNTTRHT--SWTRV---I 402

  Fly   668 PNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHS--DSCTTQPDVPFKNPDNVVGQGTEPNNL 730
            |.|.:           :|..|.|.|..|||.|:..:  |.|.|    ....|..|..:....:|:
Mouse   403 PRTGA-----------WTASVSAANSKGASAPTHINIVDLCGT----GLLAPHQVSAKSENMDNI 452

  Fly   731 VISWTPMPEIEHNAPNFHYYVSWKRDIPAAA------W---ENNNIFDWRQNNIVIADQPTFVKY 786
            :::|.| |:...:|.. .|.|.|:...|.:.      |   ..:|:......||    :| ::.|
Mouse   453 LVTWQP-PKKADSAVR-EYIVEWRALQPGSITKFPPHWLRIPPDNMSALISENI----KP-YICY 510

  Fly   787 LIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSG----YMAWTPVSEESVRG 847
            .|:|.|::   ||......:.|.|....|:..|      .||:.|..    :::||.:.....||
Mouse   511 EIRVHALS---ESQGGCSSIRGDSKHKAPVSGP------HITAITEKKERLFISWTHIPFPEQRG 566

  Fly   848 HFKGYKIQTWTENE--GEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDF 910
            ....|:|. |.|.:  .:..|.||..:...::..::..:|.......:.|.......|.....:|
Mouse   567 CILHYRIY-WKERDSTAQPELCEIQYRRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQGNEREF 630

  Fly   911 DTPEG----------------------------------------------VPSPVQG--LDAYP 927
             .|:|                                              :|.|...  :..||
Mouse   631 -CPQGKANWKAFVISSICIAIITVGTFSIRYFRQKAFTLLSTLKPQWYSRTIPDPANSTWVKKYP 694

  Fly   928 -------LGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGL 985
                   |.:...::.|..|..|. .|..:::.|..:            |.:..|
Mouse   695 ILEEKIQLPTDNLLMAWPTPEEPE-PLIIHEVLYHMI------------PVVRQP---------- 736

  Fly   986 KPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVA--PATPSFSWE--QLPS----------DN 1036
                 |..      |.|:|.:.|  .|:.:||:.:|  .||.:.:.|  ||.:          |:
Mouse   737 -----YYF------KRGQGFQGY--STSKQDAMYIANPQATGTLTAETRQLVNLYKVLESRDPDS 788

  Fly  1037 GLAKFR-------INWLPSTEGH 1052
            .||...       :|:|||.||:
Mouse   789 KLANLTSPLTVTPVNYLPSHEGY 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476
		I-set	339..427	CDD:254352	12/53 (23%)
		Ig	354..427	CDD:299845	12/53 (23%)
		I-set	432..517	CDD:254352	27/117 (23%)
		Ig	446..517	CDD:299845	20/91 (22%)
		I-set	522..611	CDD:254352	21/116 (18%)
		ig	525..609	CDD:278476	18/111 (16%)
		FN3	613..707	CDD:238020	26/110 (24%)
		FN3	716..807	CDD:238020	22/99 (22%)
		fn3	817..905	CDD:278470	18/93 (19%)
		FN3	917..1004	CDD:238020	15/95 (16%)
		FN3	1041..1111	CDD:238020	6/19 (32%)
		Bravo_FIGEY	1155..>1221	CDD:290593
Il12rb2	NP_032380.1	Lep_receptor_Ig	28..120	CDD:368845	12/55 (22%)
		FN3	240..332	CDD:238020	18/112 (16%)
		WSXWS motif	321..325		0/3 (0%)
		fn3	438..523	CDD:365830	22/94 (23%)
		FN3	536..630	CDD:238020	19/100 (19%)
		Box 1 motif	677..685		1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000