DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Col7a1

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	NP_031764.2	Gene:	Col7a1 / 12836	MGIID:	88462	Length:	2944	Species:	Mus musculus

Alignment Length:	1186	Identity:	235/1186 - (19%)
Similarity:	386/1186 - (32%)	Gaps:	361/1186 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLVALLCA-----GSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYS 70
            ||||.|||     |:.|.......|:|            ..:...:|..|::    ||......|
Mouse     5 LLVAALCAAEILMGAPEVWAQPRDRVT------------CTRLYAADIVFLL----DGSSSIGRS 53

  Fly    71 WIKNGKKFDWQAYDNRMLRQPG----RGTLVITIPKDEDRGHYQCFASNEFG--TATSNSVYVRK 129
            ..:..:.|    .:..:|...|    :|....|:...:|       ...|||  |..|.|..:|.
Mouse    54 NFREVRGF----LEGLVLPFSGAASAQGVRFATVQYSDD-------PQTEFGLDTLGSGSDTIRA 107

  Fly   130 AELNAFKDEAAKT---LEAVEGEPFMLKCAAPDGFPSPTV---NWMIQESIDGSIKSINNSRMTL 188
            ....::|....:|   |..|....|:.:...| |.|...:   :...|:.:|.:.:.:....:.|
Mouse   108 IRELSYKGGNTRTGAALHHVSDRVFLPRLTRP-GVPKVCILITDGKSQDLVDTAAQKLKGQGVKL 171

  Fly   189 --------DPEGNLWFSNVTR--EDASSDFYYACSATSVFRSEYK-IGNKVLLDVKQMGVSASQN 242
                    |||      .:.|  ...:|||::..:..|:.|:... |..:|......:.|:...:
Mouse   172 FAVGIKNADPE------ELKRVASQPTSDFFFFVNDFSILRTLLPLISRRVCTTAGGVPVTLPSD 230

  Fly   243 KHP--PVRQYVSRRQSLALR-----------GKRMELFCIYG-GTPLP---QTVWSKDGQ---RI 287
            ..|  |....:|...|.:||           |.:::...:.| |.|||   |.|....|:   |:
Mouse   231 DTPSGPRDLVLSEPSSQSLRVQWTAASGPVTGYKVQYTPLTGLGQPLPSERQEVNIPAGETSTRL 295

  Fly   288 QWSDRITQGHYGKSLVIRQTN-FDDA--GTYTCDVSNG----VGNAQSFSIILNVNSVPYFTKEP 345
            |....:|.  |..::|....| ..:|  ||.......|    :.|..|.|:::....||
Mouse   296 QGLRPLTD--YQVTVVALYANSIGEAVSGTARTTAKEGLELSLQNITSHSLLVAWRRVP------ 352

  Fly   346 EIATAAEDEEVVFECRAAGVPEPKISWIH-NGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYG 409
                              |....:::|.. :|.|.:|...:|.:
Mouse   353 ------------------GANGYRVTWRDLSGGPTQQQDLSPGQ--------------------- 378

  Fly   410 CNATNSLGYVYKDVYLNVQAEPPTISEAPAAVSTVDGRNV----TIKCRVNGSPK----PLVKWL 466
                   |.|:.|     ..||.|..|  ..||.:.|.:|    ::..|...|.:    |::  |
Mouse   379 -------GSVFLD-----HLEPGTDYE--VTVSALFGHSVGPAASLTARTASSVEQTLHPII--L 427

  Fly   467 RASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYE 531
            ..::.|.......:|.|              |....:.:.|                .:.||..|
Mouse   428 SPTSILLSWNLVPEARG--------------YRLEWRRESG----------------LETPQKVE 462

  Fly   532 VAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVA 596
            :.             .|....::|..:.|              .:..||:...:|         .
Mouse   463 LP-------------PDVTRHQLDGLQPG--------------TEYRLTLYTLLE---------G 491

  Fly   597 RTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWE--------------QQGDNRSPILHY 647
            |.....||.....:.|.|.....|..|.....:..:.|.              .||..|:.:|
Mouse   492 REVATPATVVPTGLEQLVSPVMNLQAIELPGQRVRVSWNPVPGATEYRFTVRTTQGVERTLLL-- 554

  Fly   648 TIQFNTSFTPASWDAAYEKVPNTDSSF-VVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPD 711
                                |.:.::| :..:....:||.||.|  ::||....|...:....|:
Mouse   555 --------------------PGSQTTFDLDDVRAGLSYTVRVSA--RVGAQEGDASILTIHRDPE 597

  Fly   712 VPFKNPD-NVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKR----DIPAAAWENNNIFDWR 771
            .|...|. .||  .::...:.::|..:|    .|..|.  :||:.    :.......::.:.|
Mouse   598 APLVVPGLRVV--ASDATRIRVAWGLVP----GASGFR--ISWRTGSGPESSRTLTPDSTVTD-- 652

  Fly   772 QNNIVIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMA 836
                ::..||: ..|.:.|.|:..|.|    ...||..:..| ||.......:.| ..|:|..:.
Mouse   653 ----ILGLQPS-TSYQVAVSALRGREE----GPPVVIVARTD-PLGPVRRVHLTQ-AGSSSVSIT 706

  Fly   837 WTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFN 901
            ||.|...:      ||:: :|....|.|  :.:.|.||...|.:...:||::...|:..:....:
Mouse   707 WTGVPGAT------GYRV-SWHSGHGPE--KSLLVSGDATVAEIDGLEPDTEYIVRVRTHVAGVD 762

  Fly   902 GPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERR 966
            |.|::|:....||.|.| |..|......|....:.|..  .|..  |.||:.:         .|.
Mouse   763 GAPASVVVRTAPEPVGS-VSKLQILNASSDVLRVTWVG--VPGA--TSYKLAW---------GRS 813

  Fly   967 EYDP---HITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNVAPATPS-- 1026
            |..|   .|........::..|:....|.:.:||.....||:...|..||       .||||:
Mouse   814 EGGPMKHRILPGNKESAEIRDLEGGVSYSVRVTALVGDREGAPVSIVITT-------PPATPALL 871

  Fly  1027 --------------FSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIKGETQWIRENEEKN 1077
                          ..||.:|   |...||::|.|  ||             |:.|.:....|.|
Mouse   872 ETLQVVQSGEHSLRLRWEPVP---GAPGFRLHWQP--EG-------------GQEQSLTLGPESN 918

  Fly  1078 SDYQEVGGLDPETAYE 1093
            | |..| ||:|.|.|:
Mouse   919 S-YNLV-GLEPATKYQ 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	16/78 (21%)
		IG_like	57..127	CDD:214653	15/75 (20%)
		Ig	135..214	CDD:299845	18/94 (19%)
		IG_like	141..216	CDD:214653	17/90 (19%)
		ig	251..332	CDD:278476	26/105 (25%)
		I-set	339..427	CDD:254352	10/88 (11%)
		Ig	354..427	CDD:299845	9/73 (12%)
		I-set	432..517	CDD:254352	15/92 (16%)
		Ig	446..517	CDD:299845	11/78 (14%)
		I-set	522..611	CDD:254352	12/88 (14%)
		ig	525..609	CDD:278476	12/83 (14%)
		FN3	613..707	CDD:238020	18/108 (17%)
		FN3	716..807	CDD:238020	17/95 (18%)
		fn3	817..905	CDD:278470	19/87 (22%)
		FN3	917..1004	CDD:238020	17/89 (19%)
		FN3	1041..1111	CDD:238020	18/53 (34%)
		Bravo_FIGEY	1155..>1221	CDD:290593
Col7a1	NP_031764.2	Nonhelical region (NC1). /evidence=ECO:0000255	18..1254		228/1173 (19%)
		vWA_collagen_alphaI-XII-like	38..202	CDD:238759	36/185 (19%)
		fn3	234..318	CDD:278470	20/85 (24%)
		FN3	334..414	CDD:238020	22/138 (16%)
		fn3	427..488	CDD:278470	14/117 (12%)
		fn3	510..588	CDD:278470	16/101 (16%)
		FN3	599..681	CDD:238020	20/100 (20%)
		fn3	688..765	CDD:278470	19/86 (22%)
		fn3	778..856	CDD:278470	19/91 (21%)
		fn3	874..946	CDD:278470	22/79 (28%)
		FN3	959..1046	CDD:238020
		VWA	1055..1223	CDD:278519
		Cell attachment site. /evidence=ECO:0000255	1171..1173
		Triple-helical region. /evidence=ECO:0000255	1255..2775
		Interrupted collagenous region. /evidence=ECO:0000255	1255..1475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1259..1934
		Collagen	1398..1444	CDD:189968
		Collagen	1470..1511	CDD:189968
		Collagen	1560..1624	CDD:189968
		Collagen	1601..1660	CDD:189968
		Collagen	1643..1695	CDD:189968
		Collagen	1839..1893	CDD:189968
		Collagen	1875..1931	CDD:189968
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1960..2773
		Cell attachment site. /evidence=ECO:0000255	2002..2004
		Cell attachment site. /evidence=ECO:0000255	2063..2065
		Collagen	2099..2158	CDD:189968
		Collagen	2233..2292	CDD:189968
		Collagen	2275..2338	CDD:189968
		Collagen	2448..2497	CDD:189968
		Collagen	2481..2559	CDD:189968
		Collagen	2530..2589	CDD:189968
		Collagen	2575..2632	CDD:189968
		Cell attachment site. /evidence=ECO:0000255	2601..2603
		Collagen	2605..2664	CDD:189968
		Cell attachment site. /evidence=ECO:0000255	2631..2633
		Collagen	2641..2693	CDD:189968
		Nonhelical region (NC2). /evidence=ECO:0000255	2776..2944
		KU	2877..2932	CDD:238057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000