DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and Chl1

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_006505530.1	Gene:	Chl1 / 12661	MGIID:	1098266	Length:	1225	Species:	Mus musculus

Alignment Length:	1320	Identity:	368/1320 - (27%)
Similarity:	561/1320 - (42%)	Gaps:	192/1320 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILAALLVALLCAGSAE--SKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEY 69
            ::.:|:..||...:||  ....:.|.|.||        ...|.....|..|.|||||.|.|||.:
Mouse    11 LILSLIFLLLKLSAAEIPLSVQQVPTIVKQ--------SYVQVAFPFDEYFQIECEAKGNPEPIF 67

  Fly    70 SWIKNGKKFDWQAYDNRMLRQPGRGTLVITIPKD----EDRGHYQCFASNEFGTATSNSVYVRKA 130
            ||.|:.|.||..  |.|::.....||  ..||.:    ..:|.|:|||||..|||.|..:.....
Mouse    68 SWTKDDKPFDLS--DPRIIAANNSGT--FKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVP 128

  Fly   131 ELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWM-IQ-ESIDGSIKSINNSRMTLDPEGN 193
            .:..|..|..:.::..||:..:|.|..|.|.|...:.|| |: |.|:      .:.|:.:...|:
Mouse   129 GVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIE------QDERVYMSQRGD 187

  Fly   194 LWFSNVTREDASSDFYYACSA------TSVFRSEYKIGNKVLLDVKQMGVSAS-----------Q 241
            |:|:||...|:.:|  |.|.|      |.|.:...|:   .:..:|....|:|           :
Mouse   188 LYFANVEENDSRND--YCCFAAFPKLRTIVQKMPMKL---TVNSLKHASDSSSSTEICSQANSIK 247

  Fly   242 NKHP----PVRQYVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSL 302
            .:.|    |..|..|......|:|..:.|.|...|.|.|...|||.|..:. ..|.|...:.|:|
Mouse   248 QRKPKLLLPPAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELP-EGRATIEVHEKTL 311

  Fly   303 VIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPE 367
            .|...::.|.|.|.|..:|.:|.| |....:.|...|.:.|:|:.|..:.....:..|.|.|.|:
Mouse   312 KIENISYQDRGNYRCTANNLLGKA-SHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQ 375

  Fly   368 PKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPP 432
            |.|.|..||.|||:. |.|...:....|...||:...||.|.|.|:|..|.:..:..::|....|
Mouse   376 PTIKWRLNGLPIEKH-PFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVIDVIP 439

  Fly   433 TI-SEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRA--SNWLTGGRYNVQANGDLEIQDVTFSD 494
            .| ::.....:||.|.:..:.|....|||..|.|..|  ::.|.|.||:...||.|||...|..|
Mouse   440 LIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEED 504

  Fly   495 AGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLE--IEIDWW 557
            ||.|:|:..|..|:.....:|.::..|::...|:|..:.........|....|..|:  :::.|.
Mouse   505 AGSYSCWVDNAMGKAVITANLDIRNATKLRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWS 569

  Fly   558 KDGQSIDFEAQPRFVKTNDNS-------LTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVP 615
            |||::.:...      |.|..       |||:.....|.|.|:|.|:|.||..:.:..:.|..||
Mouse   570 KDGEAFEMNG------TEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLGVP 628

  Fly   616 NAPKLTGITCQADKA-EIHWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPNTDSSFVVQM 678
            :.|....::.:.::: .:.||...|:.|.|..|.::| .....|..|: ...:|...::..|:.:
Mouse   629 DPPGNLHLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWE-ELTRVQGEETDVVLSL 692

  Fly   679 SPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHN 743
            :|:..|.|||.|.|::|.|..|..||...|.|..|.|||.|:..|.::|..::|.|.|:..:|.|
Mouse   693 APYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQN 757

  Fly   744 APNFHYYVSWKRDIPAAAWENNNIFDWRQNNIVIADQPT-FVKYLIKVVAINDRGESNVAAEEVV 807
            .|...|.||||.......||...:    .|:.:....|| :..|.:||.|||..| |:...:.|.
Mouse   758 GPGLEYKVSWKPQGAPEEWEEEIV----TNHTLRVMTPTVYAPYDVKVQAINQLG-SSPDPQPVT 817

  Fly   808 GYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTEN---EGEEGLREI 869
            .|||||.|..||. .....:.:||...:.|:.:.:|:|.|..:||:|..|...   :|....:|:
Mouse   818 LYSGEDYPSTAPV-IQRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEV 881

  Fly   870 HV---KGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSS 931
            ::   .|..::.:|....|.|:.:..:||||.:..||.|....|.||||||.....|....:...
Mouse   882 NILRFSGQRNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKD 946

  Fly   932 AFMLHWKKPLYPNGKLTGYKIYYEEVKESY-VGERREYDPHITDPRVTRMKMAGLKPNSKYRISI 995
            ...|.|..|...||.||||.:.|:.:.::| :||..|.  ::|.|..:...::.|...:||:..:
Mouse   947 TATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEI--NVTTPSKSSWHLSNLNSTTKYKFYL 1009

  Fly   996 TATTKMGEGSEHYIEKTTLKDAVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEG-------HP 1053
            .|.|..|.|.....|..||.:                 ...|:.|.       |||       ||
Mouse  1010 RACTSRGCGKPISEEGATLGE-----------------GSKGIRKI-------TEGVNVTQKIHP 1050

  Fly  1054 G----------THFFTMHRIKGETQWIRENEEKNSDYQEVGGLDPETAYEFRVVSVDGHFNTESA 1108
            .          .|..|.:       | .:|:....|..|..|.:....|
Mouse  1051 VEVLVPGAEHIVHLMTKN-------W-GDNDSIFQDVIETRGREYAGLY---------------- 1091

  Fly  1109 TQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGR 1173
                             :.::..|||||:|.|:|.:.::.:.||.::|||||||.|.::|   ..
Mouse  1092 -----------------DDISTQGWFIGLMCAIALLTLILLTICFVKRNRGGKYSVKEKE---DL 1136

  Fly  1174 RDYPE-----EGGFHEYSQPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGDTAV--------- 1224
            ...||     :..|.|||...:....|.....:.|....|| .||:.|||:||.::
Mouse  1137 HPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPTES-ADSLVEYGEGDQSIFNEDGSFIG 1200

  Fly  1225 ATAAARAAAAARSKLTSLPT 1244
            |...|:...:..|..:|..|
Mouse  1201 AYTGAKEKGSVESNGSSTAT 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	33/76 (43%)
		IG_like	57..127	CDD:214653	32/73 (44%)
		Ig	135..214	CDD:299845	24/80 (30%)
		IG_like	141..216	CDD:214653	23/82 (28%)
		ig	251..332	CDD:278476	25/80 (31%)
		I-set	339..427	CDD:254352	28/87 (32%)
		Ig	354..427	CDD:299845	24/72 (33%)
		I-set	432..517	CDD:254352	30/87 (34%)
		Ig	446..517	CDD:299845	26/72 (36%)
		I-set	522..611	CDD:254352	22/97 (23%)
		ig	525..609	CDD:278476	22/92 (24%)
		FN3	613..707	CDD:238020	26/95 (27%)
		FN3	716..807	CDD:238020	29/91 (32%)
		fn3	817..905	CDD:278470	24/93 (26%)
		FN3	917..1004	CDD:238020	24/87 (28%)
		FN3	1041..1111	CDD:238020	13/86 (15%)
		Bravo_FIGEY	1155..>1221	CDD:290593	24/70 (34%)
Chl1	XP_006505530.1	Ig	35..126	CDD:416386	39/102 (38%)
		Ig strand A	35..39	CDD:409353	2/3 (67%)
		Ig strand A'	44..48	CDD:409353	1/3 (33%)
		Ig strand B	53..60	CDD:409353	5/6 (83%)
		Ig strand C	66..71	CDD:409353	2/4 (50%)
		Ig strand C'	74..76	CDD:409353	1/1 (100%)
		Ig strand D	82..85	CDD:409353	1/2 (50%)
		Ig strand E	90..94	CDD:409353	2/5 (40%)
		Ig strand F	105..113	CDD:409353	5/7 (71%)
		Ig strand G	116..126	CDD:409353	4/9 (44%)
		IgI_2_L1-CAM_like	135..225	CDD:409432	27/100 (27%)
		Ig strand B	149..153	CDD:409432	1/3 (33%)
		Ig strand C	163..167	CDD:409432	0/3 (0%)
		Ig strand E	186..190	CDD:409432	2/3 (67%)
		Ig strand F	201..206	CDD:409432	3/6 (50%)
		Ig strand G	217..220	CDD:409432	0/2 (0%)
		Ig	262..344	CDD:416386	25/83 (30%)
		Ig strand B	274..278	CDD:409353	1/3 (33%)
		Ig strand C	287..291	CDD:409353	0/3 (0%)
		Ig strand E	309..313	CDD:409353	2/3 (67%)
		Ig strand F	323..328	CDD:409353	2/4 (50%)
		Ig strand G	336..339	CDD:409353	1/2 (50%)
		Ig4_L1-NrCAM_like	348..435	CDD:409367	27/87 (31%)
		Ig strand B	364..368	CDD:409367	0/3 (0%)
		Ig strand C	377..381	CDD:409367	1/3 (33%)
		Ig strand E	400..404	CDD:409367	1/3 (33%)
		Ig strand F	414..419	CDD:409367	2/4 (50%)
		Ig strand G	427..430	CDD:409367	0/2 (0%)
		Ig	448..525	CDD:416386	27/76 (36%)
		Ig strand A'	448..452	CDD:409353	0/3 (0%)
		Ig strand B	455..464	CDD:409353	1/8 (13%)
		Ig strand C	470..475	CDD:409353	2/4 (50%)
		Ig strand C'	478..481	CDD:409353	0/2 (0%)
		Ig strand D	486..491	CDD:409353	2/4 (50%)
		Ig strand E	492..499	CDD:409353	5/6 (83%)
		Ig strand F	506..514	CDD:409353	3/7 (43%)
		Ig strand G	517..525	CDD:409353	1/7 (14%)
		Ig strand A	529..535	CDD:409353	1/5 (20%)
		Ig strand A'	538..543	CDD:409353	1/4 (25%)
		Ig strand B	546..554	CDD:409353	1/7 (14%)
		IG_like	548..624	CDD:214653	20/81 (25%)
		Ig strand C	565..569	CDD:409353	0/3 (0%)
		Ig strand D	584..587	CDD:409353	0/2 (0%)
		Ig strand E	588..594	CDD:409353	1/5 (20%)
		Ig strand F	603..610	CDD:409353	3/6 (50%)
		Ig strand G	617..621	CDD:409353	0/3 (0%)
		FN3	628..717	CDD:238020	23/89 (26%)
		fn3	731..811	CDD:394996	28/84 (33%)
		FN3	833..927	CDD:238020	24/93 (26%)
		FN3	932..1027	CDD:238020	26/96 (27%)
		Bravo_FIGEY	1121..1202	CDD:404722	26/84 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9875
eggNOG	1	0.900	-	-		E1_KOG3513
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I994
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm43039
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.740