DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nrg and Cntn1

DIOPT Version :9

Sequence 1:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster
Sequence 2:NP_476459.1 Gene:Cntn1 / 117258 RGDID:621300 Length:1021 Species:Rattus norvegicus


Alignment Length:1053 Identity:281/1053 - (26%)
Similarity:441/1053 - (41%) Gaps:135/1053 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LLVALL-CAG------------SAESKGNRPPRITKQPA----PGELLFKVAQQNKESDNPFIIE 58
            ||::|. |.|            |.|.|| ..|...:||.    |.|.|     :.|.|     :.
  Rat    11 LLISLTSCLGEFTWHRRYGHGVSEEDKG-FGPIFEEQPINTIYPEESL-----EGKVS-----LN 64

  Fly    59 CEADGQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVITIP-KDEDRGHYQCFASNEFGTATS 122
            |.|...|.|.|.|..|....|   ..|......| |.|||..| |.:|.|.|.|.|||.:|...|
  Rat    65 CRARASPFPVYKWRMNNGDVD---LTNDRYSMVG-GNLVINNPDKQKDAGIYYCLASNNYGMVRS 125

  Fly   123 NSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSP-TVNWMIQESIDGSIKSINNSRM 186
            ....:....|:.|..|....::..||:..:|.|..|..||.. :..|::.|.  ....:::..|.
  Rat   126 TEATLSFGYLDPFPPEDRPEVKVKEGKGMVLLCDPPYHFPDDLSYRWLLNEF--PVFITMDKRRF 188

  Fly   187 TLDPEGNLWFSNVTREDASSDFYYAC--SATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVRQ 249
            .....|||:.:||...|..:   |:|  |:.|:.:|.:   :|.   :..:.:.....|..|...
  Rat   189 VSQTNGNLYIANVESSDRGN---YSCFVSSPSITKSVF---SKF---IPLIPIPERTTKPYPADI 244

  Fly   250 YVSRRQSLALRGKRMELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGT 314
            .|..:....:.|:.:.|.|...|.|:|...|.|..:.:..:..|:..  |..|.|.....:|.|.
  Rat   245 VVQFKDIYTMMGQNVTLECFALGNPVPDIRWRKVLEPMPTTAEISTS--GAVLKIFNIQLEDEGL 307

  Fly   315 YTCDVSNGVGNAQSFSIILNVNSVPYFTKEPEIATAAEDEEV------VFECRAAGVPEPKISWI 373
            |.|:..|..|..:..:.|       |....||......|.||      .:.|.|.|.|.|.|.|:
  Rat   308 YECEAENIRGKDKHQARI-------YVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWL 365

  Fly   374 HNGKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTISEAP 438
            .||....:           ..:|:.::...:.|.|.|.|.|:.|.:|.:..|.:.|..||....|
  Rat   366 KNGYAYHK-----------GELRLYDVTFENAGMYQCIAENAYGTIYANAELKILALAPTFEMNP 419

  Fly   439 --AAVSTVDGRNVTIKCRVNGSPKPLVKWLRASNWL-TGGRYNVQANGDLEIQDVTFSDAGKYTC 500
              ..:....|..|.|:|:...:|||...|.:.:.|| ...|..:..:|.|||.::|.:|.|.|||
  Rat   420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTC 484

  Fly   501 YAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDF 565
            :|:|..|:..:.|:||:...|||...|.|.::..|::||.:|..:.|.:|::...|..:|..|||
  Rat   485 FAENNRGKANSTGTLVITNPTRIILAPINADITVGENATMQCAASFDPSLDLTFVWSFNGYVIDF 549

  Fly   566 EA-------QPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAP---KL 620
            ..       |..|:...:..|.|.......:|.|||.|:|.:|.::|.|:|:|:..|..|   ::
  Rat   550 NKEITNIHYQRNFMLDANGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRI 614

  Fly   621 TGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVP----NTDSSFVVQMSPW 681
            ..|  :|....:.|.:..||.|||..||||..|..:. .|..|....|    |.:|:..|.:.||
  Rat   615 EDI--RATSVALTWSRGSDNHSPISKYTIQTKTILSD-DWKDAKTDPPIIEGNMESAKAVDLIPW 676

  Fly   682 ANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPN 746
            ..|.|||:|.|.:|...||..|:...|....|...|.:|.|.|.....|.|:|.|:....|...|
  Rat   677 MEYEFRVVATNTLGTGEPSIPSNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYHYGNN 741

  Fly   747 FHYYVSWKRDIPAAAWENNNIFD---WRQNNIVIADQPTFV----------KYLIKVVAINDRGE 798
            |.|.|::|.            ||   |::..:...|...:|          .:.:||.|.|::|:
  Rat   742 FGYIVAFKP------------FDGEEWKKVTVTNPDTGRYVHKDETMTPSTAFQVKVKAFNNKGD 794

  Fly   799 SNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGE 863
            ...:...|:. |.:|.|.:|||...::.::||... :.|..|.|:.|    :.|:|:.|..::.|
  Rat   795 GPYSLIAVIN-SAQDAPSEAPTEVGVKVLSSSEIS-VHWKHVLEKIV----ESYQIRYWAGHDKE 853

  Fly   864 EGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPL 928
            .....:.|....::|.:....||::.:..:.|.|....||.|.||:..|.:..||....:.:...
  Rat   854 AAAHRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPSSDVIETFTRKAPPSQPPRIISSVR 918

  Fly   929 GSSAFMLHWKK--PLYPNGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKY 991
            ..|.:::.|..  .|.....:|||||.|.. ...:.|:......|..:..:.|        :.:|
  Rat   919 SGSRYIITWDHVVALSNESTVTGYKILYRP-DGQHDGKLFSTHKHSIEVPIPR--------DGEY 974

  Fly   992 RISITATTKMGEG 1004
            .:.:.|.:..|:|
  Rat   975 VVEVRAHSDGGDG 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NrgNP_001245581.1 Ig 55..128 CDD:299845 25/73 (34%)
IG_like 57..127 CDD:214653 25/70 (36%)
Ig 135..214 CDD:299845 20/81 (25%)
IG_like 141..216 CDD:214653 19/77 (25%)
ig 251..332 CDD:278476 19/80 (24%)
I-set 339..427 CDD:254352 24/93 (26%)
Ig 354..427 CDD:299845 20/78 (26%)
I-set 432..517 CDD:254352 29/87 (33%)
Ig 446..517 CDD:299845 26/71 (37%)
I-set 522..611 CDD:254352 29/95 (31%)
ig 525..609 CDD:278476 26/90 (29%)
FN3 613..707 CDD:238020 33/100 (33%)
FN3 716..807 CDD:238020 24/103 (23%)
fn3 817..905 CDD:278470 21/87 (24%)
FN3 917..1004 CDD:238020 17/88 (19%)
FN3 1041..1111 CDD:238020
Bravo_FIGEY 1155..>1221 CDD:290593
Cntn1NP_476459.1 IgI_1_Contactin-1 40..134 CDD:409436 33/107 (31%)
Ig strand B 61..65 CDD:409436 1/8 (13%)
Ig strand C 74..78 CDD:409436 1/3 (33%)
Ig strand E 96..100 CDD:409436 2/3 (67%)
Ig strand F 111..116 CDD:409436 2/4 (50%)
Ig strand G 125..128 CDD:409436 1/2 (50%)
Ig2_Contactin-2-like 142..230 CDD:409392 22/98 (22%)
Ig strand B 154..158 CDD:409392 1/3 (33%)
Ig strand C 169..173 CDD:409392 0/3 (0%)
Ig strand E 194..198 CDD:409392 3/3 (100%)
Ig strand F 208..213 CDD:409392 2/7 (29%)
Ig strand G 224..227 CDD:409392 1/5 (20%)
IgI_3_Contactin-1 241..328 CDD:143259 22/95 (23%)
Ig strand B 259..263 CDD:143259 1/3 (33%)
Ig strand C 272..276 CDD:143259 0/3 (0%)
Ig strand E 293..297 CDD:143259 1/3 (33%)
Ig strand F 307..312 CDD:143259 2/4 (50%)
Ig strand G 320..323 CDD:143259 0/2 (0%)
Ig 332..408 CDD:416386 22/86 (26%)
Ig strand A 332..335 CDD:409353 1/2 (50%)
Ig strand A' 339..343 CDD:409353 2/3 (67%)
Ig strand B 347..355 CDD:409353 1/7 (14%)
Ig strand C 361..366 CDD:409353 2/4 (50%)
Ig strand C' 368..371 CDD:409353 1/2 (50%)
Ig strand E 374..379 CDD:409353 1/4 (25%)
Ig strand F 388..395 CDD:409353 3/6 (50%)
Ig strand G 399..408 CDD:409353 2/8 (25%)
Ig5_Contactin-1 413..501 CDD:409438 29/87 (33%)
Ig strand B 432..436 CDD:409438 2/3 (67%)
Ig strand C 445..449 CDD:409438 0/3 (0%)
Ig strand E 467..471 CDD:409438 2/3 (67%)
Ig strand F 481..486 CDD:409438 3/4 (75%)
Ig strand G 494..497 CDD:409438 0/2 (0%)
Ig6_Contactin 503..603 CDD:409359 30/99 (30%)
Ig strand B 522..526 CDD:409359 2/3 (67%)
Ig strand C 537..541 CDD:409359 0/3 (0%)
Ig strand E 568..572 CDD:409359 1/3 (33%)
Ig strand F 582..587 CDD:409359 3/4 (75%)
Ig strand G 595..598 CDD:409359 1/2 (50%)
FN3 612..699 CDD:238020 30/89 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..719 7/23 (30%)
FN3 711..803 CDD:238020 24/103 (23%)
fn3 813..895 CDD:394996 21/86 (24%)
FN3 907..991 CDD:238020 18/90 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3513
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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