DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and chl1b

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_017212175.2	Gene:	chl1b / 100318566	ZFINID:	ZDB-GENE-091105-1	Length:	1294	Species:	Danio rerio

Alignment Length:	1278	Identity:	367/1278 - (28%)
Similarity:	600/1278 - (46%)	Gaps:	142/1278 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PRITKQPAPGELLFKVAQQNKESDNPFIIECEADGQPEPEYSWIKNGKKFD-WQAYDNRMLRQPG 92
            |.||:. :|..|   :|...:||   |.::|||.|.||||:.|.|||:.|| :|  |.|::....
Zfish    42 PTITEY-SPASL---IAFPFEES---FPVKCEATGNPEPEFRWTKNGQDFDPYQ--DTRLITLDD 97

  Fly    93 RGTLVI--TIPKDEDRGHYQCFASNEFGTATSNSVYVRKAELNAFKDEAAKTLEAVEGEPFMLKC 155
            .||.:|  |....|.:|.|:|||:|:.|||.|..:......:..|..|....:|.:||:..:|:|
Zfish    98 SGTFIIPNTGNLTEFQGIYRCFATNKLGTAMSEEIEFIIPNVPKFPKEIIDPIEVMEGQSVILEC 162

  Fly   156 AAPDGFPSPTVNWMIQESIDGSIKSI-NNSRMTLDPEGNLWFSNVTREDASSDFYYACSA----- 214
            ..|.|.|...:.||..     |::.| .:.|:::...|||:|||....|:..|  |.|.|
Zfish   163 NPPTGIPPLQIYWMTI-----SLQHIEQDERVSVGLNGNLYFSNTVETDSRRD--YCCFAAFPRI 220

  Fly   215 -TSVFRSEYKI---GNKVLLDVKQMGVSASQNKHPPVRQYVSRRQSL-----------ALRGKRM 264
             |.|.::...:   .||::.|      |:|.:........:.|:.||           .::|:.:
Zfish   221 RTIVQKTAMSMVVKSNKLMKD------SSSGSGRGYANSLLERKPSLLAPTGMESHTRLVKGEDL 279

  Fly   265 ELFCIYGGTPLPQTVWSKDGQRIQWSDRITQGHYGKSLVIRQTNFDDAGTYTCDVSNGVGN-AQS 328
            :|.||..|.|.|:..|.|.|.. :..:|:....:||.|.:...|.:|.|.|.|...|..|. ...
Zfish   280 QLECIAEGFPTPKVEWVKIGFN-KLPERVVVESHGKLLTVEMVNEEDEGKYMCRAKNPHGEVVHH 343

  Fly   329 FSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDN 393
            |.:  .|...|.|..||:........:|:.:|...|.|:|.:.|..||:|:.:...:.|:.:.|.
Zfish   344 FHV--TVEEPPEFEIEPQSQLVTIGADVLIKCVVKGNPQPTVGWRVNGRPLNEVPTSNRKILKDG 406

  Fly   394 TIRIINLVKGDTGNYGCNATNSLGYVYKD---VYLNVQAEPPTISEAPAAVSTVDGRNVTIKCRV 455
            ||.|.|....::..|.|.|||..|.:..:   :.:|:|  |..::|.......|:|::|.:.|:|
Zfish   407 TISIHNANPENSAVYQCEATNKHGTILANANIMIMNIQ--PLILTENNLQYMAVEGKSVVMHCKV 469

  Fly   456 NGSPKPLVKWLRA--SNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVK 518
            ..||...:.|.:|  :|.:.|.|:.|..||.|||.:|...|.|:|:|:|||..|::....:|.||
Zfish   470 FSSPASSITWSKADSANAVEGERFTVHQNGSLEIHNVMKEDMGEYSCFAQNTEGKVAIAATLEVK 534

  Fly   519 EHTRITQEPQNYEVAAGQSATFRCNEAHDDTL--EIEIDWWKDGQSIDFEAQPRFVKTNDNSLTI 581
            :.|||...|::..|.||.:..|.|....|.:.  :.|:.|.|||.:::.....|:: ..|..|.|
Zfish   535 DPTRIVDPPRDLRVLAGTTIQFSCQPEFDPSFGDDFEVLWEKDGIALNGSEDGRYI-LEDGVLEI 598

  Fly   582 AKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKA-EIHWEQQGDNRSPIL 645
            ......|.|.|.|||||.:|:..|.|.|.|.|||:.|:...::....:: ::.|....|:.|.|.
Zfish   599 INVSFGDQGFYACVARTPVDQDVAVAQLSVVDVPDPPEDVILSEHNGRSVKLQWTPGDDHNSSIT 663

  Fly   646 HYTIQFNTS-FTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQ 709
            .:.::|..| ..|.|| ....:||....|..:::....:|.|||.|.|::|...||..::...|.
Zfish   664 EFVLEFEESQHEPGSW-REMMRVPGNHHSAPLKLYGHVDYRFRVSAINEVGKGRPSQSTERYKTP 727

  Fly   710 PDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWRQNN 774
            ...|.|||:|:..:...|:.:.|:|.|:..||||.|...|.||::|......|....:   ::::
Zfish   728 ASAPDKNPENIKIEAHLPHEMDINWEPLSPIEHNGPGLEYKVSYRRHGSDEDWTERMV---KRHS 789

  Fly   775 IVIADQPTFVKYLIKVVAINDRG---ESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMA 836
            .::.:.||||.|.||:.|.|..|   :..:    :..|||||.|..||.:..: ::.::|...:.
Zfish   790 FLVKNTPTFVLYEIKIQAKNHAGWGPDPKI----ITAYSGEDFPSAAPDDVAV-EVLNNTMVKVR 849

  Fly   837 WTPVSEESVRGHFKGYKIQTW--------TENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARI 893
            |..|.::.:.||..||::..|        .:..|::  ..:...|:.::|:||..||.|:....:
Zfish   850 WEHVHKDKIHGHLGGYRVSWWRLRSLLDSKKTHGDK--HTLTFSGERNHAVVTGLKPFSEYSLIV 912

  Fly   894 LAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVK 958
            :|:|.|.|||.|..::|.||||||.......|..:......|.|..|:..||.|.||.:.|:
Zfish   913 MAFNSRGNGPGSHSVNFKTPEGVPGQAAAFSATNIQKHKVTLTWSPPVDANGVLIGYILQYQ--- 974

  Fly   959 ESYVGERREYDPHIT---DPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVN- 1019
              .:....|..|.:|   .....:..:..|:..|||:..:...|::|.|.....|:||:.:|.:
Zfish   975 --LINNTEELGPLMTLNISADSNKQHLENLEALSKYKFYLRCCTRVGCGPAVSEERTTVPEATST 1037

  Fly  1020 -----------------------VAPAT-PSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTM 1060
                                   ||.|| .|.:...:.:........|:|:|.|| ...:..:..
Zfish  1038 DVASFNIRKSSSRFPPRKTTVSPVANATLSSIAVLNISTSVSHNYANISWIPGTE-QTESELYVA 1101

  Fly  1061 HRIKGETQW-IRENEEKNSDYQEVGGLDPETAYEFRVVS---VDGHFNTESATQEIDTNTVEGPI 1121
            .....|..| |.:....:..:..:.||:|.|.|..|:::   ||    ..|..:::.....:| :
Zfish  1102 FMNNREGNWKISDMLNSSKTFHIIEGLEPGTEYTVRLMTKSWVD----NSSIFEDVIRTRAKG-L 1161

  Fly  1122 MVANETVANAGWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEG----GF 1182
            ...:.:::|.|||||:|.|:|.:.::.:|.|.:.||:||||.|.::|  :...|...:|    .|
Zfish  1162 ASIHGSISNQGWFIGLMCAIALLTLIVLIACFVNRNKGGKYSVKEKE--DLHPDLESQGINDDTF 1224

  Fly  1183 HEYS----QPLDNKSAGRQSVSSANKPGVESDTDSMAEYGDGD 1221
            .|||    :||   .:.:.|::...|.|  ...|||.:|.|.|
Zfish  1225 CEYSDNDEKPL---KSSQHSLNGDLKGG--DSGDSMVDYCDED 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	33/75 (44%)
		IG_like	57..127	CDD:214653	32/72 (44%)
		Ig	135..214	CDD:299845	25/79 (32%)
		IG_like	141..216	CDD:214653	24/81 (30%)
		ig	251..332	CDD:278476	25/92 (27%)
		I-set	339..427	CDD:254352	25/90 (28%)
		Ig	354..427	CDD:299845	21/75 (28%)
		I-set	432..517	CDD:254352	29/86 (34%)
		Ig	446..517	CDD:299845	27/72 (38%)
		I-set	522..611	CDD:254352	30/90 (33%)
		ig	525..609	CDD:278476	27/85 (32%)
		FN3	613..707	CDD:238020	25/95 (26%)
		FN3	716..807	CDD:238020	27/93 (29%)
		fn3	817..905	CDD:278470	24/95 (25%)
		FN3	917..1004	CDD:238020	20/89 (22%)
		FN3	1041..1111	CDD:238020	17/73 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	24/73 (33%)
chl1b	XP_017212175.2	Ig	61..135	CDD:325142	33/75 (44%)
		Ig	138..231	CDD:325142	28/99 (28%)
		Ig	279..348	CDD:325142	21/71 (30%)
		Ig	366..438	CDD:325142	21/71 (30%)
		IG	454..533	CDD:214652	28/78 (36%)
		I-set	538..628	CDD:333254	30/90 (33%)
		FN3	632..722	CDD:238020	23/90 (26%)
		FN3	734..815	CDD:238020	27/83 (33%)
		FN3	832..931	CDD:238020	26/101 (26%)
		fn3	942..1022	CDD:306538	19/84 (23%)
		FN3	1070..1142	CDD:214495	14/72 (19%)
		Bravo_FIGEY	1196..1279	CDD:316405	25/74 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10316
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I1108
OMA	1	1.010	-	-		QHG47974
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm24295
orthoMCL	1	0.900	-	-		OOG6_101169
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880