Protein Alignment Nrg and ncam2

DIOPT Version :9

• Sequence 1: NP_001245581.1
• Gene: Nrg / 31792
• FlyBaseID: FBgn0264975
• Length: 1309
• Species: Drosophila melanogaster
• Sequence 2: XP_012811963.1
• Gene: ncam2 / 100151722
• XenbaseID: XB-GENE-1217730
• Length: 865
• Species: Xenopus tropicalis
• Alignment Length: 993
• Identity: 195/993 - (19%)
• Similarity: 346/993 - (34%)
• Gaps: 304/993 - (30%)

  Fly   280 WSKDGQRIQWSDRITQGHYG--KSLVIRQTNFDDAGTYTCDVSNGVGNAQSFSIILNV------N 336
            ::..|::|....|:.....|  ..|.|.:.|.||||.|.|..::..|:||..:::|.:      .
 Frog    83 FNPQGEKIISGQRVVVQREGIRSWLTIYKANVDDAGIYRCQATDSKGHAQEATVVLEIYQKLTFE 147

  Fly   337 SVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHNGKPIEQSTPNPRRTVTDNTIRIINLV 401
            .||    .|:.....|:.||:  |..:..|.|.:.|::|.:.:..........:.:|.::|.|:.
 Frog   148 DVP----SPQEFKRGENAEVL--CLVSSSPAPMVRWLNNREDVTDIDDRRFAMLPNNNLQIKNIS 206

  Fly   402 KGDTGNYGCNATNSL-GYV-YKDVYLNVQAEPPTISEAPAAVSTVDG-RNVTIKCRVNGSPKPLV 463
            |.|.|.|.|.....: |.: ::|:.:.|...|..:::..:..:|.|. .::|:.||..|||||.:
 Frog   207 KRDEGIYRCEGRVEVRGEIDFRDISVIVNVPPEILAQQRSFNATADRLEDITLFCRATGSPKPYI 271

  Fly   464 KWLRASNWL-TGGRYNV-QANGDLEIQDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQE 526
            .|.|....: ...:|:: :.|.:|.::::..:|:|.|.|.|.||.|..:....|.|.....|.|.
 Frog   272 TWHRNGKLVEENEKYDLREDNTELTVKNIISTDSGLYVCRATNKAGFTEKQSFLQVFVQPHIVQL 336

  Fly   527 PQNYEVAAGQSATFRCNEAHDDTLEIEIDWWKDGQSIDF----EAQPRFVKT----NDNSLTIAK 583
            .....:..|. .|..| ||..:.:. ||.|.:....:.|    ::|...:::    ..:||.|..
 Frog   337 QNETTIEHGH-VTLTC-EAEGEPIP-EITWKRSSDGMIFYDGDKSQDGRIESTGHHGKSSLHIKS 398

  Fly   584 TMELDSGEYTCVARTRLDEATARANLIVQDVPNAPKLTGITCQADKAEIHWEQQGDNRSPILHYT 648
            .|..|:|.|.|.|.:|:.   .....:..::..|||.                       |.:.|
 Frog   399 VMLSDAGRYDCEAASRIG---GHQKSMYLNIEYAPKF-----------------------ISNQT 437

  Fly   649 IQFNTSFTPASWDAAYEKVPNTDSSFVVQMSPWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVP 713
            |.:       ||:
 Frog   438 IYY-------SWE---------------------------------------------------- 443

  Fly   714 FKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRD---IPAAAWENNNIFDWRQNNI 775
             .||.|:                ..::..|.|:..|   |.||   :||.  ...||..:|....
 Frog   444 -NNPINI----------------SCDVTSNPPSSIY---WSRDKLLLPAR--NITNIKTYRDGKR 486

  Fly   776 VIADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPV 840
            ::.:        |..::.||.|..|..|...:|...::..|      |:..:.||
 Frog   487 ILLE--------ITPLSDNDFGRYNCTAINSIGSRIQEYIL------TLADVPSS---------- 527

  Fly   841 SEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGPPS 905
                                  ..|||.|.:               |:.||::.     ||.|
 Frog   528 ----------------------PYGLRVIEL---------------SQTYAKVF-----FNKP-- 548

  Fly   906 AVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESYVGERREYDP 970
                 |:..|||                 :|            .|::.::||........|.:..
 Frog   549 -----DSHGGVP-----------------IH------------HYQMDFKEVSSEIWKVVRSHGT 579

  Fly   971 HITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLKDAVNV-APATPSFSWEQLPS 1034
            .      |.:.:..|..|:.|.:.:.|....|:|.   ..||.:...:.| .|:.||...:
 Frog   580 Q------TIIVLGNLDANTTYEVKVAAVNGKGKGE---YSKTEIFQTLPVREPSPPSIHGQ---- 631

  Fly  1035 DNGLAKFRINWLPSTE-GHPGTHFFTMHRIKG-ETQWIRENEEKNSDYQEVGGLDPETAYEFRVV 1097
            ..|...|:::.....: |.|..::...:|.|. |.||:.:....|.||..:..|.....||..::
 Frog   632 PGGGKSFKLSITKQDDGGAPILNYVVKYRSKDKEDQWLEKKFLGNKDYIILDHLQWNVGYEVHII 696

  Fly  1098 SVD--GHFNTESATQEIDTNTVEGPIMVANETVANAGWFIGMMLALAFIIILFIII--------- 1151
            :.:  ||    |.....:......|.::|:...:..|  :|.::.||...:|.:::
 Frog   697 ATNRLGH----SEPTVFEFLMPPKPNIIADTLFSGLG--VGAVIGLAVAALLLVLVVTDVSCFFI 755

  Fly  1152 -------CIIRRNRG------GKYDVHDRELANGRRDYPEEGGFHEYSQPL-----DNKSAGRQS 1198
                   ||.||..|      ||    .:||..|:..|.::|.    .:|:     :::......
 Frog   756 RQCGLLMCITRRICGKKSGSSGK----SKELEEGKAAYLKDGS----KEPIVEMRTEDERVTNHD 812

  Fly  1199 VSSANKPGVESDTDSMAE 1216
            .|..|:|   ::|..:.|
 Frog   813 GSPVNEP---NETTPLTE 827

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845
		IG_like	57..127	CDD:214653
		Ig	135..214	CDD:299845
		IG_like	141..216	CDD:214653
		ig	251..332	CDD:278476	16/53 (30%)
		I-set	339..427	CDD:254352	20/89 (22%)
		Ig	354..427	CDD:299845	17/74 (23%)
		I-set	432..517	CDD:254352	24/87 (28%)
		Ig	446..517	CDD:299845	22/73 (30%)
		I-set	522..611	CDD:254352	22/96 (23%)
		ig	525..609	CDD:278476	21/91 (23%)
		FN3	613..707	CDD:238020	8/93 (9%)
		FN3	716..807	CDD:238020	20/93 (22%)
		fn3	817..905	CDD:278470	13/87 (15%)
		FN3	917..1004	CDD:238020	12/86 (14%)
		FN3	1041..1111	CDD:238020	17/73 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	16/73 (22%)
ncam2	XP_012811963.1	Ig	50..141	CDD:386229	17/57 (30%)
		IG_like	150..234	CDD:214653	20/89 (22%)
		Ig	237..330	CDD:386229	26/92 (28%)
		Ig	329..426	CDD:386229	22/102 (22%)
		IG_like	442..520	CDD:214653	23/165 (14%)
		FN3	525..617	CDD:238020	30/188 (16%)
		fn3	623..706	CDD:365830	21/90 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910