DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrg and l1cam

DIOPT Version :9

Sequence 1:	NP_001245581.1	Gene:	Nrg / 31792	FlyBaseID:	FBgn0264975	Length:	1309	Species:	Drosophila melanogaster
Sequence 2:	XP_012823307.1	Gene:	l1cam / 100124734	XenbaseID:	XB-GENE-5914700	Length:	1254	Species:	Xenopus tropicalis

Alignment Length:	1272	Identity:	369/1272 - (29%)
Similarity:	579/1272 - (45%)	Gaps:	131/1272 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILAALLVALLCA---------GSAESKGNRPPRITKQPAPGELLFKVAQQNKESDNPFIIECEAD 62
            :|..:||:|||:         |....:...||.||:|.....:|:        .::..:::|||.
Frog     9 LLGTVLVSLLCSHMEAFQLPKGYVMQEIMYPPVITEQSPEKYVLY--------PNDDIVLKCEAK 65

  Fly    63 GQPEPEYSWIKNGKKFDWQAYDNRMLRQPGRGTLVIT----IPKDEDRGHYQCFASNEFGTATSN 123
            ...:.:|:|.|:|:.|. ...|.|:.|:...|||.|:    ..|| .:|.|:|:|:|:.|||.|:
Frog    66 RNAKAKYTWKKDGETFQ-PDNDPRVSRKKDSGTLNISGNGNSMKD-FQGKYRCYATNDLGTAISH 128

  Fly   124 SVYVRKAELNAFKDEAAKTLEAVEGEPFMLKCAAPDGFPSPTVNWMIQESIDGSIKSI-NNSRMT 187
            .::|.......::.|..:.|:..||...:|.|..|.....|.|.||     :.::..| .:.|::
Frog   129 EIHVITESTPKWQKELIRPLDIEEGASLILPCNPPKSAVPPRVIWM-----NSNLLHITQDERVS 188

  Fly   188 LDPEGNLWFSNVTREDASSDFYYACSATSVFRSEYKIGNKVLLDVKQMGVSASQNKHPPVR-QYV 251
            :...|||:||||.::|...|  |.|.|.  |.....|..|..:.:|....::.:.:.|.:. ...
Frog   189 MGVNGNLYFSNVQKQDEHPD--YICHAQ--FVGARTIVQKEAISIKVRPTNSVKFRKPEMMLPEG 249

  Fly   252 SRRQSLALRGKRMELFCIYGGTPLPQTVW-----SKDGQRIQWSDRITQGHYGKSLVIRQTNFDD 311
            |....||||.:.::|.||..|.|.|:..|     |...:|||:.|      :.|:|.|.:...:|
Frog   250 SMSTVLALRDQPLQLECIAEGLPTPEIEWIPLLGSTYNERIQFDD------FKKTLHIDKVQDED 308

  Fly   312 AGTYTCDVSNGVG-NAQSFSIILNVNSVPYFTKEPEIATAAEDEEVVFECRAAGVPEPKISWIHN 375
            .|.|.|...|..| ::.:|:::  |.|.||:..:||....|..|:::..|...|.|:||::|..|
Frog   309 DGDYQCIAKNTQGSSSHTFTVV--VESAPYWINKPEDGIYAPGEDIILHCEVGGKPKPKVTWKIN 371

  Fly   376 GKPIEQSTPNPRRTVTDNTIRIINLVKGDTGNYGCNATNSLGYVYKDVYLNVQAEPPTI-SEAPA 439
            ||.::.|.......:.|.::.:.|:...||....|.|.|..|.:..:.::.|...||.| :....
Frog   372 GKSLKDSDLYHNWKLIDGSLVLNNMQLNDTSVVQCEARNKHGNLLANAFVYVVELPPQILTRNDE 436

  Fly   440 AVSTVDGRNVTIKCRVNGSPKPLVKWLR--ASNWLTGGRYNVQANGDLEIQDVTFSDAGKYTCYA 502
            ....|:..||::.||..|:|.|.::|..  ..|.....::::..||.|.|..|...|.|.|.|.|
Frog   437 QYIVVEKTNVSMDCRAFGTPFPTIQWESDLEDNLFALDQFSMHTNGTLTITGVAKEDEGIYRCTA 501

  Fly   503 QNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEIE-IDWWKDGQSIDFE 566
            .|..|.:.....|.|:..|:|...|.......|..|.|:|....|..:..: |.|.|:|..|..:
Frog   502 SNNQGNVSISAYLDVRNATKIITPPMEQHARKGGKAIFQCKVEFDPKMSDKIIQWRKNGNEIKED 566

  Fly   567 AQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQDVPNAP-KLTGITCQADKA 630
            |........|.:|:|:...|.|.|.|||.|.|.||.....|.|:|.|:|.|| .|.....|....
Frog   567 ADNDKYFIEDYTLSISNVQESDHGMYTCAAHTELDAVELTAELVVIDLPEAPFDLELSNAQETSI 631

  Fly   631 EIHWEQQGDNRSPILHYTIQF-NTSFTPASWDAAYEKVPNTDSSFV---VQMSPWANYTFRVIAF 691
            .:.|....||.|||..:.|:: ..||.|..|    .::...|....   :.:||:.||.|||||.
Frog   632 TLTWTPGNDNNSPIEEFIIEYEEDSFEPGVW----HELTRVDGDMFNVDLDLSPYVNYQFRVIAV 692

  Fly   692 NKIGASPPSAHSDSCTTQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIEHNAPNFHYYVSWKRD 756
            |::|.|..|..||...|....|.|||..|.|:||||.|:.|||.|:..|:.|.|.|.|.|.| |.
Frog   693 NEVGPSNGSNPSDRYETPAFAPAKNPREVKGEGTEPQNMYISWKPLKGIDWNGPGFKYLVKW-RQ 756

  Fly   757 IPAAAWENNNIFDWRQNNIVIADQP--------TFVKYLIKVVAINDRGESNVAAEEVVGYSGED 813
            :....|:.           |:||.|        .|..|.|.|.::||.|.: ...:.|:|:||||
Frog   757 LGKEEWKE-----------VVADSPPVLVSGTSIFEPYEIIVQSVNDIGRA-TEPKPVIGHSGED 809

  Fly   814 RPLDAPTNFTMRQITSSTSGYMAWTPVSEESVRGHFKGYKIQTWTENEGEEGLREIHVKGDTHNA 878
            .|...|.|..:..:..|.. .:||.||.:..:.||.||:.:.....|.......::.|.|:|.:|
Frog   810 MPDITPENVGLEAMNESAI-KVAWLPVQKNGLNGHLKGFMVYYTRHNGHNRHPGKLLVHGNTTHA 873

  Fly   879 LVTQFKPDSKNYARILAYNGRFNGPPSAVIDFDTPEGVPSPVQGLDAYPLGSSAFMLHWKKPLYP 943
            |:|..||.|.....:...||:..|..|......|.||||||...|.......::..|.|..|..|
Frog   874 LITGLKPYSNYSVEVAIINGKGEGEHSESRMIRTDEGVPSPPSFLRLERQSDTSLTLIWGPPETP 938

  Fly   944 NGKLTGYKIYYEEVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHY 1008
            ||.||||:||::.|.:::.| .:.:...|.||......::.:.....||..:.|||.:|:.....
Frog   939 NGILTGYEIYHQIVNKTHTG-AKYFSETINDPTQQNWTLSNISSKDTYRFYLYATTSVGQSEAVM 1002

  Fly  1009 IEKTTLKD-----AVNVAPATPSFSWEQLPSDNGLAKFRINWLPSTEGHPGTHFFTMHRIK-GET 1067
            :|.:|:::     .:||:..|         .||.:.   :||: ..||..........|.| .|.
Frog  1003 VEGSTMQEIEVPPVLNVSIET---------GDNVVT---LNWM-QLEGPSNAEIRVEIRNKSSEL 1054

  Fly  1068 QWIRENEEKNSDYQ-EVGGLDPETAYEFRVVSVDGHFNTESATQEIDTNTVEGPIMVANETVANA 1131
            .|........:|.. ::.||.|.|.|..|:::::...:.|..:..:.|:....|.....  ..|.
Frog  1055 LWRHYGSVNTTDSTFQLSGLLPGTFYFIRLMALNHTQHVEIWSDMVQTSGTAIPTKQGG--FPNE 1117

  Fly  1132 GWFIGMMLALAFIIILFIIICIIRRNRGGKYDVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGR 1196
            ||||.::.|:..::::.:|:|.|:|::||||.|.|:|...|..:          ::|:.:::.|.
Frog  1118 GWFIALITAIVVLLLILLILCFIKRSKGGKYSVKDKEDTQGDSE----------ARPMKDETFGE 1172

  Fly  1197 -QSVSSAN--KPGVES------------DTDSMAEYG 1218
             :|:.|.|  ||...|            ..||:|:||
Frog  1173 YRSLESDNDEKPFTSSQPSLNGEIKQLGSDDSLADYG 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrg	NP_001245581.1	Ig	55..128	CDD:299845	26/76 (34%)
		IG_like	57..127	CDD:214653	26/73 (36%)
		Ig	135..214	CDD:299845	24/79 (30%)
		IG_like	141..216	CDD:214653	24/75 (32%)
		ig	251..332	CDD:278476	27/86 (31%)
		I-set	339..427	CDD:254352	24/87 (28%)
		Ig	354..427	CDD:299845	19/72 (26%)
		I-set	432..517	CDD:254352	25/87 (29%)
		Ig	446..517	CDD:299845	22/72 (31%)
		I-set	522..611	CDD:254352	28/89 (31%)
		ig	525..609	CDD:278476	26/84 (31%)
		FN3	613..707	CDD:238020	33/98 (34%)
		FN3	716..807	CDD:238020	33/98 (34%)
		fn3	817..905	CDD:278470	24/87 (28%)
		FN3	917..1004	CDD:238020	27/86 (31%)
		FN3	1041..1111	CDD:238020	16/71 (23%)
		Bravo_FIGEY	1155..>1221	CDD:290593	22/79 (28%)
l1cam	XP_012823307.1	Ig	58..133	CDD:386229	26/76 (34%)
		Ig2_L1-CAM_like	136..230	CDD:143253	28/102 (27%)
		Ig3_L1-CAM_like	262..332	CDD:319298	22/77 (29%)
		Ig	349..424	CDD:386229	19/74 (26%)
		Ig	446..513	CDD:319273	20/66 (30%)
		Ig	521..611	CDD:386229	28/89 (31%)
		FN3	615..704	CDD:238020	30/92 (33%)
		FN3	717..795	CDD:238020	32/89 (36%)
		FN3	815..907	CDD:238020	25/92 (27%)
		fn3	913..999	CDD:365830	26/86 (30%)
		fn3	1014..1088	CDD:365830	20/86 (23%)
		Bravo_FIGEY	1141..1226	CDD:372781	22/79 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9772
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	579	1.000	Inparanoid score	I1016
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208655at33208
OrthoFinder	1	1.000	-	-		FOG0000777
OrthoInspector	1	1.000	-	-		otm48163
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060