Protein Alignment Spn75F and SERPINB3

DIOPT Version :10

• Sequence 1: NP_001036614.1
• Gene: Spn75F / 317912
• FlyBaseID: FBgn0052203
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_008850.1
• Gene: SERPINB3 / 6317
• HGNCID: 10569
• Length: 390
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 90/401 - (22%)
• Similarity: 166/401 - (41%)
• Gaps: 89/401 - (22%)

  Fly    22 FEINLTKQLSKGRLARNFVYSPIAIRQALGLLYL-SKDNVTDQQLESALQLTGLNQ--------- 76
            |..:|.:|..|.: ..|..||||:|..|||::.| :||| |.||::..|....:.:
Human    11 FMFDLFQQFRKSK-ENNIFYSPISITSALGMVLLGAKDN-TAQQIKKVLHFDQVTENTTGKAATY 73

  Fly    77 ------------EEIISLFKEARE----KVAQEQFTMGNRIYLSPDYNASPNITQLSENLGVEVK 125
                        :::::.|.::.:    |:|.:.|.....::|....:|.....|.|      |:
Human    74 HVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLDAIKKFYQTS------VE 132

  Fly   126 NMTFSGDQSAASEIKKWLNKWIGKAGG----NLFGKNDISQTTQIVAVQGMSYSCVWK---NRET 183
            ::.|:   :|..|.:|.:|.|:.....    ||..:.:|...|.:|.|..:.:...|:   |:|.
Human   133 SVDFA---NAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKED 194

  Fly   184 ALTNRTFTLLRQNKKPFVYTTQMM--YTEAPMDFFNNDQVRGVMVPFKNSDMGMLVLLPRPRYST 246
            ....:.:    .||..: .:.|||  ||........:.|.:.:.:|:|..|:.|:||||......
Human   195 TKEEKFW----PNKNTY-KSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGL 254

  Fly   247 QQILYSL--DTILK---IKLRRSKKTHLFLPKFKVSESVDLNMALKALGIQNLFTNTNA------ 300
            |::...|  :.:::   ::..|..:..|.||:|||.||.||...|:.:|:.::| |.:|
Human   255 QKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIF-NGDADLSGMT 318

  Fly   301 ------------ANFKQYNSFDADQNRVLMTIDVG-------DDFDDRVVYVNRGFVFVVKDKST 346
                        ..|.:.....|:.......:..|       ::|     :.|..|:|.::...|
Human   319 GSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEF-----HCNHPFLFFIRQNKT 378

  Fly   347 --IYMIGRMDA 355
              |...||..:
Human   379 NSILFYGRFSS 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn75F	NP_001036614.1	serpin	20..352	CDD:381000	88/396 (22%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	90/401 (22%)