Protein Alignment Spn75F and SERPINB5

DIOPT Version :10

• Sequence 1: NP_001036614.1
• Gene: Spn75F / 317912
• FlyBaseID: FBgn0052203
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_002630.2
• Gene: SERPINB5 / 5268
• HGNCID: 8949
• Length: 375
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 77/374 - (20%)
• Similarity: 145/374 - (38%)
• Gaps: 56/374 - (14%)

  Fly    22 FEINLTKQLSKGRLARNFVYSPIAIRQALGLLYLSKDNVTDQQLESALQLTGLNQEEIISLFKEA 86
            |.::|.|||.:.....|.::|||.:..:|.|..:.....|..::...|...  |.:::...|:..
Human    11 FAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFE--NVKDVPFGFQTV 73

  Fly    87 REKVAQ----EQFTMGNRIYLSPDYNASPN-ITQLSENLGVEVKNMTFSGDQSAASEIKKWLNKW 146
            ...|.:    ....:..|:|:....|.|.. |:........|::.:.|   :....|.|..:|..
Human    74 TSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDF---KDKLEETKGQINNS 135

  Fly   147 IGKAGG----NLFGKNDISQTTQIVAVQGMSYSCVW--KNRETALTNRTFTLLRQNKKPFVYTTQ 205
            |.....    |:...|.::..|:|:.|....:...|  |..|:......|.:.:.:.||    .|
Human   136 IKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKP----VQ 196

  Fly   206 MMYTEAPMDFFNNDQV--RGVMVPFKNSDMGMLVLLPR---------PRYSTQQILYSLDTILKI 259
            ||..||.....|.|.:  :.:.:||:|..:.|.:|||:         .:...|....||......
Human   197 MMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNP 261

  Fly   260 KLRRSKKTHLFLPKFKVSESVDLNMALKALGIQNLFTNTNAANFKQYNSFDADQNRVL------- 317
            ....:.|..|.:|||||.:.:|....|:.||::::|:...:    .::.....:...|
Human   262 STMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTS----DFSGMSETKGVALSNVIHKV 322

  Fly   318 ---MTIDVGDDFD---DRVVY------VNRGFVFVVKDKST--IYMIGR 352
               :|.|.||..:   .|::.      .:..|:::::...|  |...|:
Human   323 CLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGK 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn75F	NP_001036614.1	serpin	20..352	CDD:381000	76/372 (20%)
SERPINB5	NP_002630.2	serpinB5_maspin	1..375	CDD:381013	77/374 (21%)