Protein Alignment Spn75F and SERPINC1

DIOPT Version :10

• Sequence 1: NP_001036614.1
• Gene: Spn75F / 317912
• FlyBaseID: FBgn0052203
• Length: 356
• Species: Drosophila melanogaster
• Sequence 2: NP_001373231.1
• Gene: SERPINC1 / 462
• HGNCID: 775
• Length: 505
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 77/404 - (19%)
• Similarity: 156/404 - (38%)
• Gaps: 99/404 - (24%)

  Fly    38 NFVYSPIAIRQALGLLYLSKDNVTDQQLESALQLTGLNQ---EEIISLFKEA-----REKVAQEQ 94
            |...||::|..|..:..|...|.|.|||....:...:::   ::|...|.:.     |:.....:
Human   107 NIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYRKANKSSK 171

  Fly    95 FTMGNRIYLSPDYNASPNITQLSENL-GVEVKNMTF--SGDQSAASEIKKWLNKWI-GKAGG--- 152
            ....||::.......:.....:||.: |.:::.:.|  :.:||.|:     :|||: .|..|
Human   172 LVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAA-----INKWVSNKTEGRIT 231

  Fly   153 NLFGKNDISQTTQIVAVQGMSYSCV----------------------WKNRE----TALTNRTFT 191
            ::.....|::.|.:|.|..:.:..:                      |::|.    ..|...|..
Human   232 DVIPSEAINELTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQG 296

  Fly   192 LLR------QNKKPFVY-------TTQMMYTEAPMDFFNNDQVRGVM-VPFKNSDMGMLVLLPRP 242
            |.:      ..:|...|       :..|||.|....:....:...|: :|||..|:.|:::||:|
Human   297 LWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVAEGTQVLELPFKGDDITMVLILPKP 361

  Fly   243 RYS--------TQQILYS-LDTILKIKLRRSKKTHLFLPKFKVSESVDLNMALKALGIQNLFTNT 298
            ..|        |.::|.. ||.:.::.|      .:.:|:|::.:...|...|:.:|:.:||:..
Human   362 EKSLAKVEKELTPEVLQEWLDELEEMML------VVHMPRFRIEDGFSLKEQLQDMGLVDLFSPE 420

  Fly   299 NA--------------------ANFKQYNSFDADQNRVLMTIDVGDDFD-DRVVY-VNRGFVFVV 341
            .:                    ..|.:.|...::.......:..|...: :||.: .||.|:..:
Human   421 KSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFI 485

  Fly   342 KD--KSTIYMIGRM 353
            ::  .:||..:||:
Human   486 REVPLNTIIFMGRV 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn75F	NP_001036614.1	serpin	20..352	CDD:381000	75/401 (19%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	77/404 (19%)